Hostname: page-component-8448b6f56d-xtgtn Total loading time: 0 Render date: 2024-04-19T10:36:15.344Z Has data issue: false hasContentIssue false
  • English
  • Français

Immunocytochemical identification of HIV (p24) antigen in parotid lymphoid lesions

Published online by Cambridge University Press:  29 June 2007

J. M. Bruner ,
K. R. Cleary ,
F. B. Smith  and
J. G. Batsakis
J. M. Bruner
Affiliation:
Department of Pathology, The University of Texas MD., Anderson Cancer Center at Houston
K. R. Cleary
Affiliation:
Department of Pathology, The University of Texas MD., Anderson Cancer Center at Houston
F. B. Smith
Affiliation:
Department of Pathology, St. Vincent's Hospital, New York, New York.
J. G. Batsakis*
Affiliation:
Department of Pathology, The University of Texas MD., Anderson Cancer Center at Houston
*
John G. Batsakis, MD, Department of Pathology, The University of Texas MD, Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas (713) 793-3100
Get access Rights & Permissions [Opens in a new window]

Abstract

Antibodies to specific human immunodeficiency virus (HIV) polypeptides are important laboratory markers of HIV infection. We have used an antibody to the major structural gag protein p24 of HIV-1 virus to immunochemically localize this capsid antigen in lymphoid cells from seven of eight patients at risk for HIV infection and who presented with parotid lymphadenopathy and lymphoepithelial cysts of the parotid gland. A clinicopathological assessment of these two manifestations as they relate to HIV infection is also presented.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 103 , Issue 11 , November 1989 , pp. 1063 - 1066
Copyright
Copyright © JLO (1984) Limited 1989

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Batsakis, J. G. (1982) The pathology of head and neck tumours. The lymphoepithelial lesion and Sjögren's syndrome. Head and Neck Surgery, 5: 150–163.CrossRefGoogle ScholarPubMed
Cohen, M. N., Rao, U. and Shedd, D. P. (1984) Benign cysts of the parotid gland. Journal of Surgical Oncology, 27: 85–88.CrossRefGoogle ScholarPubMed
Colebunders, R., Francis, H., Mann, J. M., Bila, K. M., Kandi, K., Lebughe, I., Gigase, P., Van Marck, E., Macher, A. M., Quinn, T. C., Curran, J. W. and Piot, P. (1988) Parotid swelling during human immunodeficiency virus infection. Archives of Otolaryngology, 114: 330–332.CrossRefGoogle ScholarPubMed
Couderc, L-J., D'Agay, M-F., Danon, F., Harzic, M., Brocheriou, C. and Clauvel, J-P. (1987) Sicca complex and infection with human immunodeficiency virus. Archives of Internal Medicine, 147: 898–901.CrossRefGoogle ScholarPubMed
Eneroth, C-M. (1964) Histological and clinial aspects of parotid tumours. Acta Otolaryngologica Supplement 191: 1–99.Google Scholar
Finfer, M. D., Schinella, R. A., Rothstein, S. G. and Persky, M. S. (1988) Cystic parotid lesions in patients at risk for the acquired immunodeficiency syndrome. Archives of Otolaryngology, 114: 1290–1294.CrossRefGoogle ScholarPubMed
Holliday, R. A., Cohen, W. A., Schinella, R. A., Rothstein, S. G., Persky, M. S., Jacobs, J. M. and Som, P. M. (1988) Benign lymphoepithelial parotid cysts and hyperplastic cervical adenopathy in AIDS-risk patients: a new CT appearance. Radiology, 168: 439–441.CrossRefGoogle ScholarPubMed
Hsu, S. M., Raine, L. and Fanger, H. (1981) Use of avidinboitinperoxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabelled antibody (PAP) procedures. Journal of Histochemistry and Cytochemistry, 29: 577–580.CrossRefGoogle ScholarPubMed
Ioachim, H. L. and Ryan, J. R. (1988) Salivary gland lymphadenopathies associated with AIDS. Human Pathology, 19: 616–617.CrossRefGoogle ScholarPubMed
Ioachim, H. L., Ryan, J. R. and Blaugrund, S. M. (1988) Salivary gland lymph nodes. The site of lymphadenopathies and lymphomas associated with human immunodeficiency virus infection. Archives of Pathology and Laboratory Medicine, 112: 1224–1228.Google ScholarPubMed
Kornstein, D. J., Parker, G. A. and Mills, A. S. (1988) Immunohistology of the benign lymphoepithelial lesion in AIDS-related lymphadenopathy: A case report. Human Pathology, 19: 1359–1361.CrossRefGoogle ScholarPubMed
Lathrop, F. D. (1962) Benign tumours of the parotid gland; a 25 year review. Laryngoscope, 72: 992–1006.CrossRefGoogle Scholar
Richardson, G. S., Clairmont, A. A. and Erickson, E. R. (1978) Cystic lesions of the parotid gland. Plastic and Reconstructive Surgery, 61: 364–370.CrossRefGoogle ScholarPubMed
Ryan, J. R., Ioachim, H. L., Marmer, J. and Loubeau, J. M. (1985) Acquired immune deficiency syndrome—related lymphadenopathies presenting in the salivary gland lymph nodes. Archives of Otolaryngology, 111: 554–556.CrossRefGoogle ScholarPubMed
Shaha, A., Thelmo, W. and Jaffe, B. M. (1988) Is parotid lymphadenopathy a new disease or part of AIDS? American Journal of Surgery, 156: 297–300.CrossRefGoogle ScholarPubMed
Shugar, J. M. A., Som, P. M., Ryan, J. R., Jacobsen, A. L., Bernard, P. J. and Dickman, S. H. (1988) Multicentric parotid cysts and cervical adenopathy in AIDS patients. A newly recognized entity: CT and MR manifestations. Laryngoscope, 98: 772–775.CrossRefGoogle ScholarPubMed
Smith, F. B., Rajdeo, H., Panesar, N., Bhuta, K. and Stahl, R. (1988) Benign lymphepithelial lesion of the parotid gland in intravenous drug users. Archives of Pathology and Laboratory Medicine, 112: 742–745.Google Scholar
Tanaka, A., O'Sullivan, F. X., Koopman, W. J. and Gay, S. (1988) Ultrastructural study of Sjögren's syndrome-like disease in MRL/1 mice. Journal of Oral Pathology, 17: 460–465.CrossRefGoogle Scholar
Ulirsch, R. C. and Jaffe, E. S. (1987) Sjögren's syndrome-like illness associated with the acquired immunodeficiency syndrome-related complex. Human Pathology, 18: 1063–1068.CrossRefGoogle ScholarPubMed
Veronese, F. D. M., Sarngadharan, M. G., Rahman, R., Markham, P. D., Popovic, M., Bodner, A. J. and Gallo, R. C. (1985) Monoclonal antibodies specific for p24, the major core protein of human T-cell leukemia virus type III. Proceedings of the National Academy of Sciences, USA, 82: 5199–5602.CrossRefGoogle Scholar