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Growing versus non-growing vestibular schwannomas: assessment of natural history

Published online by Cambridge University Press:  01 October 2021

A Dardis ,
K Donghun  and
G Kontorinis Open the ORCID record for G Kontorinis [Opens in a new window]
A Dardis
Affiliation:
Medical School, University of Glasgow, Glasgow, Scotland, UK
K Donghun
Affiliation:
Medical School, University of Glasgow, Glasgow, Scotland, UK
G Kontorinis*
Affiliation:
Medical School, University of Glasgow, Glasgow, Scotland, UK Department of Otorhinolaryngology – Head and Neck Surgery, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
*
Author for correspondence: Prof Georgios Kontorinis, Department of Otolaryngology – Head and Neck Surgery, Queen Elizabeth University Hospital, 1345 Govan Road, GlasgowG51 4TF, Scotland, UK E-mail: gkontorinis@gmail.com
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Abstract

Objective

Vestibular schwannomas can demonstrate great heterogeneity in their behaviour; approximately one-third will grow and two-thirds will not. This study aimed to determine whether there are factors present at diagnosis that can help predict outcomes.

Methods

This retrospective cohort study compared data from 735 patients from the past 20 years. Analysis of serial magnetic resonance imaging was carried out to place patients into growing and non-growing cohorts. Factors including size, age, follow-up time and presence of balance symptoms were compared.

Results

The median size of a growing vestibular schwannoma at diagnosis was 13 mm, whereas the non-growing median size was 10.65 mm (p < 0.001). Balance symptoms were present in 60.76 per cent of growing vestibular schwannoma patients but only in 38.75 per cent of patients with non-growing vestibular schwannomas (p < 0.001).

Conclusion

This study highlights initial tumour size and balance symptoms as potential predictors of whether or not a vestibular schwannoma will grow; these results better facilitate our understanding of vestibular schwannoma natural history.

Keywords

DizzinessGrowthNeuromaVertigoVestibular Schwannoma
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 10 , October 2022 , pp. 934 - 938
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Prof G Kontorinis takes responsibility for the integrity of the content of the paper

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