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Basaloid squamous cell carcinoma of the head and neck: report of 18 cases

Published online by Cambridge University Press:  30 March 2011

O Choussy ,
M Bertrand ,
A François ,
E Blot ,
H Hamidou  and
D Dehesdin
O Choussy*
Affiliation:
Department of Head and Neck Surgery, Rouen University Hospital, Rouen, France
M Bertrand
Affiliation:
Department of Head and Neck Surgery, Rouen University Hospital, Rouen, France
A François
Affiliation:
Department of Pathology, Rouen University Hospital, Rouen, France
E Blot
Affiliation:
Department of Oncology and Radiotherapy, Centre Henri Becquerel, Rouen, France
H Hamidou
Affiliation:
Department of Oncology and Radiotherapy, Centre Henri Becquerel, Rouen, France
D Dehesdin
Affiliation:
Department of Head and Neck Surgery, Rouen University Hospital, Rouen, France
*
Address for correspondence: Dr Olivier Choussy, Department of Head and Neck Surgery, Rouen University Hospital – Charles Nicolle, 1 rue de Germont, Rouen 76031, France Fax: + 33 2 32 88 83 59 E-mail: olivier.choussy@chu-rouen.fr
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Abstract

Objective:

To evaluate the clinical course and pathological characteristics of basaloid head and neck squamous cell carcinoma.

Method:

Retrospective study of 18 cases of basaloid head and neck squamous cell carcinoma. Epidemiological, clinical and histological data were analysed and the Kaplan–Meier test used to estimate survival rates.

Results:

The majority of lesions were at an advanced stage. These lesions were primarily localised in the larynx, hypopharynx and oropharynx. Routine pre-therapeutic assessment of squamous cell carcinoma was performed. Pathological diagnosis was difficult, although immunostaining was extremely useful. Positive staining for KL1, MNF 116 and 34βE12 and negative immunostaining for chromogranin and synaptophysin were also important factors in obtaining a definitive diagnosis. In the majority of cases, treatment involved surgery and radiotherapy. The five-year survival rate was 5 per cent.

Conclusion:

Basaloid squamous cell carcinoma is an uncommon head and neck lesion, with a challenging histological diagnosis. These lesions must be carefully monitored due to their aggressive course, and require multimodality treatment.

Keywords

Carcinoma, Squamous CellHead And Neck NeoplasmsPathologyPrognosis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 6 , June 2011 , pp. 608 - 613
Copyright
Copyright © JLO (1984) Limited 2011

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