Skip to main content Accessibility help
×
Home
Hostname: page-component-79b67bcb76-c2bf7 Total loading time: 0.419 Render date: 2021-05-16T23:04:52.965Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": false, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true }

Comparison of oral steroid regimens for acute acoustic trauma caused by gunshot noise exposure

Published online by Cambridge University Press:  11 June 2019

N Choi
Affiliation:
Department of Otorhinolaryngology, Republic of Korea Armed Forces Capital Hospital, Bundang, Republic of Korea
J S Kim
Affiliation:
28th Regiment, 9th Division, Republic of Korea Armed Forces, Goyang, Republic of Korea
Y-S Chang
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Korea University College of Medicine, Korea University Ansan Hospital, Ansan-si, Republic of Korea
Corresponding
E-mail address:
Get access

Abstract

Background

There are no definite guidelines regarding the most adequate steroid regimens for acute acoustic trauma.

Objective

To elucidate the dose-dependent differing benefits of oral steroids on hearing improvement following acute acoustic trauma.

Methods

Twenty-nine patients treated with oral steroids following a diagnosis of unilateral acute acoustic trauma were retrospectively reviewed. Patients were sorted into two groups with an oral steroid regimen. Group 1 received a 14-day course of treatment: 60 mg prednisolone daily for 10 days, tapering off over days 11–14. Group 2 received prednisolone for a total of 10 days: 60 mg for 5 days, tapering down each day for the remainder. Multivariable linear regression analysis was performed to evaluate the factors associated with the hearing gain.

Results

In the multivariable regression (R2 = 0.51, p < 0.001), patients in group 1 showed more significant improvement in the degree of hearing gain compared to group 2 (p = 0.03).

Conclusion

After comparing the differing benefits of oral steroids on hearing improvement by dosage, we recommend a high dose of prednisolone (60 mg per day) for 10 days, tapering over the remaining 4 days, for better hearing recovery following acute acoustic trauma.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited, 2019 

Access options

Get access to the full version of this content by using one of the access options below.

Footnotes

Dr Y-S Chang takes responsibility for the integrity of the content of the paper

References

1Roberto, M, Zito, F. Scar formation following impulse noise-induced mechanical damage to the organ of Corti. J Laryngol Otol 1988;102:29CrossRefGoogle ScholarPubMed
2Yong, JS, Wang, DY. Impact of noise on hearing in the military. Mil Med Res 2015;2:6CrossRefGoogle ScholarPubMed
3Lin, CY, Wu, JL, Shih, TS, Tsai, PJ, Sun, YM, Ma, MC et al. N-Acetyl-cysteine against noise-induced temporary threshold shift in male workers. Hear Res 2010;269:42–7CrossRefGoogle ScholarPubMed
4Wells, TS, Seelig, AD, Ryan, MA, Jones, JM, Hooper, TI, Jacobson, IG et al. Hearing loss associated with US military combat deployment. Noise Health 2015;17:3442CrossRefGoogle ScholarPubMed
5Flottorp, G. Treatment of noise induced hearing loss. Scand Audiol Suppl 1991;34:123–30Google ScholarPubMed
6Remenschneider, AK, Lookabaugh, S, Aliphas, A, Brodsky, JR, Devaiah, AK, Dagher, W et al. Otologic outcomes after blast injury: the Boston Marathon experience. Otol Neurotol 2014;35:1825–34CrossRefGoogle ScholarPubMed
7Bonfort, G, Billot, D, Trendel, D, Salf, E, Lindas, P, Barberot, JP. Acute acoustic trauma, a retrospective analysis about 225 military cases [in French]. Rev Laryngol Otol Rhinol (Bord) 2014;135:2531Google Scholar
8Yehudai, N, Fink, N, Shpriz, M, Marom, T. Acute acoustic trauma among soldiers during an intense combat. J Am Acad Audiol 2017;28:436–43CrossRefGoogle ScholarPubMed
9Chang, YS, Bang, KH, Jeong, B, Lee, GG. Effects of early intratympanic steroid injection in patients with acoustic trauma caused by gunshot noise. Acta Otolaryngol 2017;137:716–19CrossRefGoogle ScholarPubMed
10Harada, H, Shiraishi, K, Kato, T. Prognosis of acute acoustic trauma: a retrospective study using multiple logistic regression analysis. Auris Nasus Larynx 2001;28:117–20CrossRefGoogle ScholarPubMed
11Psillas, G, Pavlidis, P, Karvelis, I, Kekes, G, Vital, V, Constantinidis, J. Potential efficacy of early treatment of acute acoustic trauma with steroids and piracetam after gunshot noise. Eur Arch Otorhinolaryngol 2008;265:1465–9CrossRefGoogle ScholarPubMed
12Chang, Y-S, Bang, K, Choi, N, Kim, JS, Lee, G-G. Factors associated with the benefits of concurrent administration of intratympanic steroid injection with oral steroids in patients with acute acoustic trauma. Otol Neurotol 2018;39:565–70CrossRefGoogle ScholarPubMed
13Zhou, Y, Zheng, G, Zheng, H, Zhou, R, Zhu, X, Zhang, Q. Primary observation of early transtympanic steroid injection in patients with delayed treatment of noise-induced hearing loss. Audiol Neurootol 2013;18:8994CrossRefGoogle ScholarPubMed
14Maassen, M, Babisch, W, Bachmann, KD, Ising, H, Lehnert, G, Plath, P et al. Ear damage caused by leisure noise. Noise Health 2001;4:116Google ScholarPubMed

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Comparison of oral steroid regimens for acute acoustic trauma caused by gunshot noise exposure
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Comparison of oral steroid regimens for acute acoustic trauma caused by gunshot noise exposure
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Comparison of oral steroid regimens for acute acoustic trauma caused by gunshot noise exposure
Available formats
×
×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *