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The effect of anti-Anisakis simplex antibody levels on C3 and C4 complement components in human sera

Published online by Cambridge University Press:  31 May 2011

P. García-Hernández ,
M. Rodero ,
R. Gisbert-Criado ,
P. Puente ,
V. Pelayo ,
J.C. Andreu-Ballester  and
C. Cuéllar
P. García-Hernández
Affiliation:
Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
M. Rodero
Affiliation:
Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
R. Gisbert-Criado
Affiliation:
Departamento de Bioquímica, Hospital Arnau de Vilanova, Valencia, Spain
P. Puente
Affiliation:
Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
V. Pelayo
Affiliation:
Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
J.C. Andreu-Ballester
Affiliation:
Servicio de Urgencias, Hospital Arnau de Vilanova, Valencia, Spain
C. Cuéllar*
Affiliation:
Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
*
*Fax: +34913941815 E-mail: cuellarh@farm.ucm.es
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Abstract

Previously, an in vitro effect was observed on the complement system not only of the excretory-secretory products but also of somatic antigens from L3 Anisakis simplex larvae. In the present work the effect of anti-A. simplex specific antibodies on C3 and C4 levels in human sera was investigated. Up to 309 samples of sera were tested to determine levels of C3 and C4 and anti-A. simplex antibodies, including immunoglobulins IgG, IgM, IgA and IgE. Significant differences were observed between levels of C3 and C4 and all immunoglobulins except for IgE. In the case of immunoglobulins, the probability that an anti-A. simplex positive subject has a C3 deficiency was 3.8 times higher than a subject without specific antibodies. In conclusion, an association between elevated levels of anti-A. simplex antibodies and C3 and C4 deficiency was demonstrated.

Type
Research Papers
Information
Journal of Helminthology , Volume 86 , Issue 2 , June 2012 , pp. 197 - 201
Copyright
Copyright © Cambridge University Press 2011

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