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The antifilarial activity of a novel group of organic arsenicals upon Brugia pahangi

Published online by Cambridge University Press:  05 June 2009

D. A. Denham ,
Sheree L. Oxenham ,
I. Midwinter  and
E. A. H. Friedheim
D. A. Denham
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT England
Sheree L. Oxenham
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT England
I. Midwinter
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT England
E. A. H. Friedheim
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT England
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Abstract

Mel W is a second generation anionic organic arsenical which is filaricidal but has sporadic and unacceptable lethal side effects. Eight new cationic derivatives have now been synthesized in an attempt to avoid the side effects and have been examined for their effects upon adult Brugia pahangi in Meriones unguiculatus. They were all shown to be potent filaricides and the two best compounds, Mel Ga and Mel Cy, were at least 95% effective in killing adult B. pahangi at 5x3–13 mg/kg when injected subcutaneously.

Keywords

Brugia pahangiMeriones unguiculatusarsenicalsfilaricides
Type
Research Article
Information
Journal of Helminthology , Volume 60 , Issue 3 , September 1986 , pp. 169 - 172
Copyright
Copyright © Cambridge University Press 1986

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References

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