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The use of gamma-radiation-attenuated larvae of Gaigeria pachyscelis Railliet and Henry, 1910, for vaccination in lambs*

Published online by Cambridge University Press:  05 June 2009

Md. Zafrullah Ansari  and
Kunwar Suresh Singh
Md. Zafrullah Ansari
Affiliation:
Division of Parasitology, Indian Veterinary Research Institute, Izatnagar, (U.P.), India
Kunwar Suresh Singh
Affiliation:
Division of Parasitology, Indian Veterinary Research Institute, Izatnagar, (U.P.), India
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Abstract

The results of a vaccination trial in lambs with gamma-irradiated infective larvae of Gaigeria pachyscelis are described. A single percutaneous (P/C) vaccination of lambs with 2000 infective larvae irradiated at 40 Kr induced the development of resistance. The vaccinated lambs successfully resisted a lethal challenge infection of 5000 non-irradiated larvae 3 months later. In the vaccinated lambs, the manifestations of resistance were shown by marked reduction in the worm establishment, development of retarded and functionally sterile worms and absence of clinical signs of hookworm disease after the challenge infection.

Type
Research Papers
Information
Journal of Helminthology , Volume 52 , Issue 4 , December 1978 , pp. 287 - 290
Copyright
Copyright © Cambridge University Press 1978

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References

REFERENCES

Alicata, J. E. (1951) Effects of roentgen radiation on Trichinella spiralis. Journal of Parasitology, 37, 491–501.CrossRefGoogle ScholarPubMed
Dow, C., Jarrett, W. F. H., Jennings, F. W., McIntyre, W. I. M. and Mulligan, W. (1959) The production of active immunity against the canine hookworm, Uncinaria stenocephala. Journal of American Veterinary Medical Association, 135, 407–411.Google ScholarPubMed
Jarrett, W. F. H., McIntyre, W. I. M., Jennings, F. W. and Mulligan, W. (1957) The natural history of parasitic bronchitis with notes on prophylaxis and treatment. Veterinary Record, 69, 1329–1336.Google Scholar
Jarrett, W. F. H., Jennings, F. W., McIntyre, W. I. M., Mulligan, W. and Urquhart, G. M. (1958) Irradiated helminth larvae in vaccination. Proceedings of Royal Society of Medicine, 51, 743–744.CrossRefGoogle ScholarPubMed
Miller, T. A. (1964) Effect of X-irradiation upon the infective larvae of Ancylostoma caninum and the immunogenic effect in dogs of a single infection with 40 Kr irradiated larvae. Journal of Parasitology, 50, 735–742.CrossRefGoogle ScholarPubMed
Miller, T. A. (1970) Canine hookworm vaccine. Journal of American Veterinary Medical Association (abstract), 156, 1239–1240.Google Scholar
Schwartz, B. (1921) Effect of X-rays on trichinae. Journal of Agricultural Research, 20, 845–854.Google Scholar
Sokolic, A., Jovanovic, M., Cuperlovic, K. and Movsesijan, M. (1963) Inhibition of the development of Dictyocaulus filaria as an expression of immunity attained in sheep. Journal of Parasitology, 49, 612–616.Google ScholarPubMed
Sokolic, A., Jovanovic, M., Cuperlovic, K. and Movsesijan, M. (1965) Vaccination against Dictyocaulus filaria with irradiated larvae. British Veterinary Journal, 121, 212–222.Google Scholar
Tewari, H. C., Rao, Y. V. B. G. and Dhar, D. N. (1972) Studies on radiation attenuated helminth vaccines; laboratory studies on the production and evaluation of gamma-irradiated vaccine against the sheep lungworm, Dictyocaulus filaria. Indian Journal of Animal Sciences, 42, 32–37.Google Scholar
Urquhart, G. M., Jarrett, W. F. H. and Mulligan, W. (1962) Helminth immunity. Advances in Veterinary Science, 7, 87–130.Google Scholar