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Efficacy of ivermectin against Parastrongylus malaysiensis infection in rats

Published online by Cambridge University Press:  05 June 2009

S. Ambu
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
J. W. Mak
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
C. S. Ng
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia

Abstract

The efficacy of ivermectin on experimental infections of P. malaysiensis in rats was determined. Ivermectin was 99·4% and 97·9% effective at a dosage of 400 mcg and 800 mcg respectively at seven days post-infection. The same two dosages of ivermectin when given at 14 days post infection had an efficacy of 100%. However, as an adulticide it had only 40·7% efficacy. Ivermectin may therefore be useful for the treatment of parastrongyliasis due to the larval stages of the worm which can cause significant pathology in man and animals.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1992

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References

Alicata, J. E. & Jindarak, K. (1970) Angiostrongylosis in the Pacific and Southeast Asia. Springfield, Illinois, USA. Ed. Thomas, Charles C.. pp. 105.Google Scholar
Ambu, S. & Mak, J. W. (1981) The effect of mebendazole and flubendazole on Angiostrongylus malaysiensis infection in rats. Southeast Asian Journal of Tropical Medicine and Public Health, 12, 228230.Google Scholar
Ambu, S., Kwa, B. H., Mak, J. W. & Singh, K. I. (1982a) Chemotherapy and chemoprophylaxis of Angiostrongylus malaysiensis infection in rats with levamisole and mebendazole. Folia Parasitologica, 29, 361364.Google ScholarPubMed
Ambu, S., Kwa, B. H. & Mak, J. W. (1982b) Studies on the experimental chemotherapy of Angiostrongylus malaysiensis infection in rats with mebendazole and levamisole. Transactions of the Royal Society of Tropical Medicine and Hygiene, 76, 458462.CrossRefGoogle ScholarPubMed
Ambu, S., Kwa, B. H., Mak, J. W. & Inder, Singh (1983) Effect of diethylcarbamazine citrate on Angiostrongylus malaysiensis infection in rats. Japanese Journal of Medical Science and Biology, 36, 325330.CrossRefGoogle ScholarPubMed
Ambu, S., Mak, J. W., Kwa, B. H. & Inder, Singh (1985a) The histopathological changes seen in the brain of treated and untreated mice infected with Angiostrongylus malaysiensis. Tropical Biomedicine 2, 8791.Google Scholar
Ambu, S., Kwa, B. H. & Mak, J. W. (1985b) Histopathology of rats infected with Angiostrongylus malaysiensis before and after drug treatment. Tropical Biomedicine 2, 3033.Google Scholar
Cross, J. H. (1979) Experimental studies on Angiostrongylus species and strains in monkeys and laboratory animals. pp. 118137. In: Studies on Angiostrongyliasis in Eastern Asia and Australia. Editor, Cross, J. H.. A special publication of the US Naval Medical Research Unit No 2, Taipei, Taiwan.Google Scholar
Ishii, A. I., Terada, M. & Sano, M. (1985) Studies on chemotherapy of parasitic helminths. (XXIII). Effects of ivermectin on Angiostrongylus cantonensis in rats. Japanese Journal of Parasitology, 34, 411417.Google Scholar
Lim, B. L. & Ramachandran, C. P. (1979) Ecological studies on Angiostrongylus malaysiensis (Nematoda: Metastrongylidae) in Malaysia. In: Studies on Angiostrongyliasis in Eastern Asia and Australia. Editor, Cross, J. H.. A special publication of the US Naval Medical Research Unit No. 2, Taipei, Taiwan.Google Scholar
Mak, J. W., Lam, P. L. W., Noor Rain, A. & Suresh, K. (1988) Effect of ivermectin against subperiodic Brugia malayi infection in the leaf monkey, Presbytis cristata. Parasitology Research, 74, 383385.CrossRefGoogle ScholarPubMed
Maki, J. & Yanagisawa, T. (1983) A comparison of the effects of flubendazole and thiabendazole on the larvae of Angiostrongylus cantonensis, Trichinella spiralis, Diphyllobothrium erinacei and Hymenolepis nana in mice. Parasitology, 87, 525531.CrossRefGoogle ScholarPubMed
Maki, J. & Yanagisawa, T. (1986) Studies on anthelmintic effects of flubendazole and mebendazole on the rat lung worm, Angiostrongylus cantonensis in mice and rats. Journal of Parasitology, 72, 512516.CrossRefGoogle Scholar
Punyagupta, S. (1979) Angiostrongyliasis: Clinical features and human pathology. In: Studies on Angiostrongyliasis in Eastern Asia and Australia. Editor, Cross, J. H.. A special publication of the US Naval Medical Research Unit No. 2, Taipei, Taiwan.Google Scholar
Terada, M. & Sano, M. (1986) Effects of diethylcarbamazine on the motility of Angiostrongylus cantonensis and Dirofilaria immitis. Zeitschrift für Parasitenkunde, 73, 375385.CrossRefGoogle Scholar
Terada, M., Ishii, A. I., Kino, H. & Sano, M. (1984) Angiostrongylus cantonensis: paralysis due to avermectin B1a and ivermectin. Experimental Parasitology, 57, 149157.CrossRefGoogle ScholarPubMed
Terada, M., Dharejo, A. M., Ishii, A. I., Nacapunchai, D. & Sano, M. (1987) Effects of milbemycin D on adult Angiostrongylus cantonensis in rats. Parasitology Research, 73,375380.CrossRefGoogle ScholarPubMed
Uberlaker, J. E. (1986) Systematics of species referred to the genus Angiostrongylus. Journal of Parasitology, 72, 237244.CrossRefGoogle Scholar

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