Hostname: page-component-cd4964975-96cn4 Total loading time: 0 Render date: 2023-03-29T18:06:36.946Z Has data issue: true Feature Flags: { "useRatesEcommerce": false } hasContentIssue true

Cross-resistance between Strongyloides venezuelensis and S. ratti in mice

Published online by Cambridge University Press:  05 June 2009

M. Korenaga*
Department of Oncology, Kumamoto University Medical School, 2-2-1 Honjo, Kumamoto 860, Japan
Y. Hitoshi
Department of Immunology, Institute of Medical Sciences, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan
K. Takatsu
Department of Immunology, Institute of Medical Sciences, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan
I. Tada
Department of Parasitology, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812, Japan
*Correspondence and present address: Department of Parasitology, Kochi Medical School, Nankoku, Kochi 783, Japan.


Cross-resistance between Strongyloides venezuelensis and S. ratti was tested in mice. The mice were immunized with S. ratti and challenged with infective filariform larvae or larvae recovered from the lungs of mice, of a heterologous species, S. venezuelensis. In this system, cross-resistance was expressed to the intestinal stage but not to the migrating stage of the parasite. Anti-interleukin (IL)-5 monoclonal antibody (mAb) treatment showed that peripheral blood eosinophilia after infection with both species of the genus Strongyloides was dependent on IL-5. Cross-resistance expressed to the intestinal stages was inhibited partially by injection of anti-IL-5 mAb.

Research Papers
Copyright © Cambridge University Press 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)


Abe, T., Sugaya, H., Yoshimura, K. & Nawa, Y. (1992) Induction of the expulsion of Strongyloides ratti and retention of Nippostrongylus brasiliensis in athymic nude mice by repetitive administration of recombinant IL-3. Immunology 76, 1014.Google Scholar
Coffman, R.L., Shrader, B., Carty, J., Mosmann, T.R. & Bond, M.W. (1987) A mouse T cell product that preferentially enhances IgA production. I. Biologic characterization. Journal of Immunology 139, 36853690.Google Scholar
Dawkins, H.J.S. & Grove, D.I. (1981) Transfer by serum and cells of resistance to infection with Strongyloides ratti in mice. Immunology 43, 317322.Google ScholarPubMed
Dawkins, H.J.S. & Grove, D.I. (1982) Immunisation of mice against Strongyloides ratti. Zeitschrift für Parasitenkunde 66, 327333.CrossRefGoogle ScholarPubMed
Harada, N., Takahashi, T., Matsumoto, M., Kinashi, T., Ohara, J., Kikuchi, Y., Koyama, N., Severinson, E., Yaoita, Y., Honjo, T., Yamaguchi, N., Tominaga, A. & Takatsu, K. (1987) Production of a monoclonal antibody useful in the molecular characterization of murine T-cell-replacing factor/B-cell growth factor II. Proceedings of the National Academy of Sciences, USA 84, 45814585.CrossRefGoogle ScholarPubMed
Hasegawa, H., Orido, Y., Sato, Y. & Otsuru, M. (1988) Strongyloides venezuelensis Brumpt, 1934 (Nematoda: Strongyloididae) collected from Rattus norvegicus in Naha, Okinawa, Japan. Japanese Journal of Parasitology 37, 429434.Google Scholar
Khan, A.I., Horii, Y., Tiuria, R., Sato, Y. & Nawa, Y. (1993) Mucosal mast cell and the expulsive mechanisms of mice against Strongyloides venezuelensis. International Journal for Parasitology 23, 551555.CrossRefGoogle ScholarPubMed
Kazakos, K.R. (1976) Increased resistance in the rat to Strongyloides ratti following immunization against Trichinella spiralis. Journal of Parasitology 62, 493494.CrossRefGoogle Scholar
Kazacos, K.R. & Thorson, R.E. (1975) Cross-resistance betweenNippostrongylus brasiliensis and Strongyloides ratti in rats. Journal of Parasitology 61, 525529.CrossRefGoogle Scholar
Korenaga, M., Hitoshi, Y., Takatsu, K. & Tada, I. (1994) Regulatory effect of anti-IL-5 monoclonal antibody on intestinal worm burden in a primary infection with Strongyloides venezuelensis in mice. International Journal for Parasitology 24, 951957.CrossRefGoogle Scholar
Korenaga, M., Hitoshi, Y., Yamaguchi, N., Sato, Y., Takatsu, K. & Tada, I. (1991) The role of interleukin-5 in protective immunity to Strongyloides venezuelensis infection in mice. Immunology 72, 502507.Google ScholarPubMed
Korenaga, M., Nawa, Y., Mimori, T. & Tada, I. (1983) Strongyloides ratti: Role of enteral antigenic stimuli by adult worms in the generation of protective immunity in rats. Experimental Parasitology 55, 358363.CrossRefGoogle ScholarPubMed
Little, M.D. (1961) Concurrent infections of Strongyloides venezuelensis and S. ratti in wild rats in New Orleans. Journal of Parasitology 47, 17.Google Scholar
Minematsu, T., Yamazaki, S., Uji, Y., Okabe, H., Korenaga, M. & Tada, I. (1990) Analysis of polyunsaturated fatty acid composition of Strongyloides ratti in relation to development. Journal of Helminthology 64, 303309.CrossRefGoogle Scholar
Moqbel, R. & Wakelin, D. (1979) Trichinella spiralis and Strongyloides ratti: Immune interaction in adult rats. Experimental Parasitology 47, 6572.CrossRefGoogle ScholarPubMed
Nawa, Y., Mimori, T., Korenaga, M. & Tada, I. (1982) Stage-specific cross-resistance between Nippostrongylus brasiliensis and Strongyloides ratti (Nematoda) in rats. Journal of Parasitology 68, 804808.CrossRefGoogle ScholarPubMed
Northern, C. & Grove, D.I. (1988) Western blot analysis of reactivity to larval and adult Strongyloides ratti antigens in mice. Parasite Immunology 10, 681691.CrossRefGoogle ScholarPubMed
Sato, Y., Inoue, F., Kiyuna, S. & Shiroma, Y. (1990) Immunoblot analysis of three antigen preparations from Strongyloides stercoralis larvae in human strongyloidiasis. Japanese Journal of Parasitology 39, 258266.Google Scholar
Sato, Y. & Toma, H. (1990) Effects of spleen cells and serum on transfer of immunity to Strongyloides venezuelensis infection in hypothymic (nude) mice. International Journal for Parasitology 20, 6367.CrossRefGoogle ScholarPubMed
Sheldon, A.J. (1937) Studies on active acquired resistance, natural and artificial, in the rat to infection with Strongyloides ratti. American Journal of Hygiene 25, 5365.Google Scholar
Tada, I., Mimori, T. & Nakai, M. (1979) Migration route of Strongyloides ratti in albino rats. Japanese Journal of Parasitology 28, 219227.Google Scholar
Wertheim, G. & Lengy, J. (1964) The seasonal occurrence of Strongyloides ratti Sandground, 1925 and of S. venezuelensis Brumpt, 1934 in a population of Rattus norvegicus. Journal of Helminthology 38, 393398.CrossRefGoogle Scholar