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Cross-resistance between Strongyloides venezuelensis and S. ratti in mice

Published online by Cambridge University Press:  05 June 2009

M. Korenaga ,
Y. Hitoshi ,
K. Takatsu  and
I. Tada
M. Korenaga*
Affiliation:
Department of Oncology, Kumamoto University Medical School, 2-2-1 Honjo, Kumamoto 860, Japan
Y. Hitoshi
Affiliation:
Department of Immunology, Institute of Medical Sciences, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan
K. Takatsu
Affiliation:
Department of Immunology, Institute of Medical Sciences, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan
I. Tada
Affiliation:
Department of Parasitology, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812, Japan
*
*Correspondence and present address: Department of Parasitology, Kochi Medical School, Nankoku, Kochi 783, Japan.
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Abstract

Cross-resistance between Strongyloides venezuelensis and S. ratti was tested in mice. The mice were immunized with S. ratti and challenged with infective filariform larvae or larvae recovered from the lungs of mice, of a heterologous species, S. venezuelensis. In this system, cross-resistance was expressed to the intestinal stage but not to the migrating stage of the parasite. Anti-interleukin (IL)-5 monoclonal antibody (mAb) treatment showed that peripheral blood eosinophilia after infection with both species of the genus Strongyloides was dependent on IL-5. Cross-resistance expressed to the intestinal stages was inhibited partially by injection of anti-IL-5 mAb.

Type
Research Papers
Information
Journal of Helminthology , Volume 69 , Issue 2 , June 1995 , pp. 119 - 123
Copyright
Copyright © Cambridge University Press 1995

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