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Prenatal alcohol exposure and developmental programming of mental illness

Part of: DOHaD ANZ Conference 2018: Genes, Environment and Evolution

Published online by Cambridge University Press:  20 February 2020

Danielle J. Burgess  and
Karen M. Moritz Open the ORCID record for Karen M. Moritz [Opens in a new window]
Danielle J. Burgess
Affiliation:
School of Biomedical Sciences, The University of Queensland, St Lucia, 4072, QLD, Australia
Karen M. Moritz*
Affiliation:
School of Biomedical Sciences, The University of Queensland, St Lucia, 4072, QLD, Australia Child Health Research Centre, The University of Queensland, South Brisbane, QLD4101, Australia
*
Address for correspondence: Professor Karen Moritz, Child Health Research Centre, The University of Queensland, Graham Street, South Brisbane, QLD4101, Australia. Email: k.moritz@uq.edu.au.
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Abstract

It is well established that high-dose alcohol consumption during pregnancy increases the risk for a plethora of adverse offspring outcomes. These include neurodevelopmental, cognitive and social deficits, as well as psychiatric illnesses, such as depression and anxiety. However, much less evidence is available on the effects of low- and early-dose alcohol exposure on mental health outcomes, regardless of the accumulating evidence that mental health outcomes should be considered in the context of the Developmental Origins of Health and Disease hypothesis. This review will discuss the evidence that indicates low-dose and early prenatal alcohol exposure can increase the risk of mental illness in offspring and discuss the mechanistic pathways that may be involved.

Keywords

Foetal alcohol spectrum disorderprenatal alcoholbehavioural disorders
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 11 , Issue 3 , June 2020 , pp. 211 - 221
Copyright
© The Author(s) 2020. Published by Cambridge University Press and the International Society for Developmental Origins of Health and Disease

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