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Neurodevelopmental assessment of infants born to mothers with hypertensive disorder of pregnancy at six months of age

Published online by Cambridge University Press:  20 May 2021

Marisa E. Sala ,
M. Florencia Romero ,
Anabella Romero ,
M. Victoria Fasano ,
Ana M. Varea ,
Patricia Carrera ,
Martín R. Salazar ,
Walter G. Espeche  and
Horacio F. González Open the ORCID record for Horacio F. González [Opens in a new window]
Marisa E. Sala
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Ministerio de Salud de la Provincia de Buenos Aires, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina
M. Florencia Romero
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Ministerio de Salud de la Provincia de Buenos Aires, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina
Anabella Romero
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Ministerio de Salud de la Provincia de Buenos Aires, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina
M. Victoria Fasano
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Ministerio de Salud de la Provincia de Buenos Aires, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina
Ana M. Varea
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Ministerio de Salud de la Provincia de Buenos Aires, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina
Patricia Carrera
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Ministerio de Salud de la Provincia de Buenos Aires, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina Unidad de Estudios Cardiometabólicos, Servicio de Clínica Médica, Hospital Interzonal General de Agudos “Gral. José de San Martín,” La Plata, Ministerio de Salud de la Provincia de Buenos Aires, 1900La Plata, Buenos Aires, Argentina
Martín R. Salazar
Affiliation:
Unidad de Estudios Cardiometabólicos, Servicio de Clínica Médica, Hospital Interzonal General de Agudos “Gral. José de San Martín,” La Plata, Ministerio de Salud de la Provincia de Buenos Aires, 1900La Plata, Buenos Aires, Argentina
Walter G. Espeche
Affiliation:
Unidad de Estudios Cardiometabólicos, Servicio de Clínica Médica, Hospital Interzonal General de Agudos “Gral. José de San Martín,” La Plata, Ministerio de Salud de la Provincia de Buenos Aires, 1900La Plata, Buenos Aires, Argentina
Horacio F. González*
Affiliation:
IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Ministerio de Salud de la Provincia de Buenos Aires, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina
*
Address for correspondence: Horacio F. González, IDIP – Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri,” Hospital de Niños “Sor María Ludovica” de La Plata, Calle 63 n°1069, 1900La Plata, Argentina. Phone/fax: +54 221 4535901 ext. 1767-1409. Email: horaciofgonzalez@gmail.com
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Abstract

Infant neurodevelopment is a complex process which may be affected by different events during pregnancy, such as hypertensive disorders of pregnancy (HDP). We conducted a prospective cohort study to compare the prevalence of neurodevelopmental disorders in infants born to mothers with and without HDP at six months of age. Participants attended the Health Observatory of Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri” during 2018 and 2019. Infant neurodevelopment was assessed with the Bayley Scales of Infant and Toddler Development—Third Edition (Bayley-III). Data were analyzed using Chi-square, Student’s t-test and Mann–Whitney test. Of the 132 participating infants, 68 and 64 were born to mothers with and without HDP, respectively. At six months, the prevalence of risk of neurodevelopmental delay was significantly higher in infants born to mothers with than without HDP (27.9% vs. 9.4%; p = 0.008) (odds ratio, 3.71; 95% confidence interval, 1.30; 12.28). In conclusion, infants born to mothers with HDP had three times increased risk of neurodevelopmental delay at six months of age.

Keywords

Infant neurodevelopmenthypertensive disorder of pregnancy
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 13 , Issue 2 , April 2022 , pp. 197 - 203
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Copyright
© The Author(s), 2021. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

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References

Gutson, K, Cacchiarelli, N, Crea, V. Guía para el seguimiento del desarrollo infantil en la práctica pediátrica. Arch Argent Pediatr. 2017; 115 (Supl. 3), s53–s62.Google Scholar
Sommerfelt, K, Andersson, HW, Sonnander, K, et al. Behavior in term, small for gestational age preschoolers. Early Hum Dev. 2001; 65, 107–121.CrossRefGoogle ScholarPubMed
Many, A, Fattal, A, Leitner, Y, et al. Neurodevelopmental and cognitive assessment of children born growth restricted to mothers with and without preeclampsia. Hypertens Pregnancy. 2003; 22, 25–29.CrossRefGoogle ScholarPubMed
Lagercrantz, H, Ringstedt, T. Organization of the neuronal circuits in the central nervous system during development. Acta Paediatr. 2001; 90, 707–715.CrossRefGoogle ScholarPubMed
Innis, SM. Impact of maternal diet on human milk composition and neurological development of infants. Am J Clin Nutr. 2014; 99, 734S–741S.CrossRefGoogle ScholarPubMed
Rätsep, MT, Paolozza, A, Hickman, AF, et al. Brain structural and vascular anatomy is altered in offspring of pre-eclamptic pregnancies: a pilot study. Am J Neuroradiol. 2016; 37, 939–945.CrossRefGoogle ScholarPubMed
Penkler, M, Hanson, M, Biesma, R, Müller, R. DOHaD in science and society: emergent opportunities and novel responsibilities. J Dev Orig Health Dis. 2019; 10, 268–273.CrossRefGoogle ScholarPubMed
Maher, GM, O’Keeffe, GW, Kenny, LC, et al. Hypertensive disorders of pregnancy and risk of neurodevelopmental disorders in the offspring: a systematic review and meta analysis protocol. BMJ Open. 2017; 7, e018313.CrossRefGoogle ScholarPubMed
Geelhoed, JJ, Fraser, A, Tilling, K, et al. Preeclampsia and gestational hypertension are associated with childhood blood pressure independently of family adiposity measures: the Avon Longitudinal. Study of Parents and Children. Circulation. 2010; 122, 1192–1199.CrossRefGoogle ScholarPubMed
Roberts, JM, Catov, JM. Preeclampsia more than 1 disease: or is it? Hypertension. 2008; 51, 989–990.CrossRefGoogle Scholar
Sibai, BM, Lindheimer, M, Hauth, J, et al. Risk factors for preeclampsia, abruptio placentae, and adverse neonatal outcomes among women with chronic hypertension. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. N Engl J Med. 1998; 339, 667–671.CrossRefGoogle ScholarPubMed
Warshafsky, C, Pudwell, J, Walker, M, et al. Prospective assessment of neurodevelopment in children following a pregnancy complicated by severe pre-eclampsia. BMJ Open. 2016; 6, e010884 CrossRefGoogle ScholarPubMed
Murray, E, Fernandes, M, Fazel, M, Kenned, S H, Villar, J, Stein, A. Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review. BJOG. 2015; 122, 1062–1072.CrossRefGoogle ScholarPubMed
Baschat, A. Neurodevelopment after fetal growth restriction. Fetal Diagn Ther. 2014; 36, 136–142.CrossRefGoogle ScholarPubMed
Bayley, N. Scales of Infant and Toddler Development, Third Edition, 2006, Pearson, San Antonio, TX, USA.Google Scholar
Romero, MF, Copparoni, JP, Fasano, MV, et al. Assessment of sensorimotor intelligence and psychomotor development in clinically healthy infants assisted in the public health sector. Arch Argent Pediatr. 2019; 117, 224–229.Google ScholarPubMed
Ego, A. Definitions: small for gestational age and intrauterine growth retardation. J Gynecol Obstet Biol Reprod (Paris). 2013; 42, 872–894.CrossRefGoogle ScholarPubMed
De Onis, M, Onyango, AW, Borghi, E, Garza, C, Yang, H. Comparison of the World Health Organization (WHO) Child Growth Standards and the National Center for Health Statistics/WHO international growth reference: implications for child health programmers. Public Health Nutr. 2006; 9, 942–947.CrossRefGoogle Scholar
Sociedad Argentina de Pediatría. Comité Nacional de Crecimiento y Desarrollo. Guía para la Evaluación del Crecimiento Físico, 3ra edición. 2013; Sociedad Argentina de Pediatría, Buenos Aires.Google Scholar
Calvo, EB, López, LB, Balmaceda Ydel, V, et al. Reference charts for weight gain and body mass index during pregnancy obtained from a healthy cohort. J Matern Fetal Neonatal Med. 2009; 22, 36–42.CrossRefGoogle ScholarPubMed
World Health Organization: obesity and overweight. Available at: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.Google Scholar
Leeman, L, Dresang, LT, Fontaine, P. Hypertensive disorders of pregnancy. Am Fam Physician. 2016; 93, 121–127.Google ScholarPubMed
Browne, JL, Vissers, KM, Antwi, E, et al. Perinatal outcomes after hypertensive disorders in pregnancy in a low resource setting. Trop Med Int Health. 2015; 20, 1778–1786.CrossRefGoogle Scholar
Dude, AM, Shahawy, S, Grobman, WA. Delivery-to-delivery weight gain and risk of hypertensive disorders in a subsequent pregnancy. Obstet Gynecol. 2018; 132, 868–874.CrossRefGoogle Scholar
Skrypnik, D, Bogdański, P, Zawiejska, A, Wender-Ożegowska, E. Role of gestational weight gain, gestational diabetes, breastfeeding, and hypertension in mother-to-child obesity transmission. Pol Arch Intern Med. 2019; 129, 267–275.Google ScholarPubMed
Zhang, S, Wang, L, Leng, J, et al. Hypertensive disorders of pregnancy in women with gestational diabetes mellitus on overweight status of their children. J Hum Hypertens. 2017; 31, 731–736.CrossRefGoogle ScholarPubMed
Perrella, S, Gridneva, Z, Lai, CT, et al. Human milk composition promotes optimal infant growth, development and health. Semin Perinatol. 2021; 45, 151380.CrossRefGoogle ScholarPubMed
Chen, Z, Li, R, Liu, H, et al. Impact of maternal hypertensive disorders on offspring’s neurodevelopment: a longitudinal prospective cohort study in China. Pediatr Res. 2020; 10.1038/s41390-020-0794-9.CrossRefGoogle ScholarPubMed
Liu, Q, Jin, S, Sun, X, et al. Maternal blood pressure, cord glucocorticoids, and child neurodevelopment at 2 years of age: a birth cohort study. Am J Hypertens. 2019; 32, 524–530.CrossRefGoogle ScholarPubMed
van Wassenaer, AG, Westera, J, van Schie, PE, et al. Outcome at 4.5 years of children born after expectant management of early onset hypertensive disorders of pregnancy. Am J Obstet Gynecol. 2011; 204, 510.e1–e9.CrossRefGoogle ScholarPubMed
Liu, L, Lin, Z, Zheng, B, et al. Reduced intellectual ability in offspring born from preeclamptic mothers: a prospective cohort study. Risk Manag Healthc Policy. 2020; 13, 2037–2046.CrossRefGoogle ScholarPubMed
Walker, CK, Krakowiak, P, Baker, A, et al. Preeclampsia, placental insufficiency, and autism spectrum disorder or developmental delay. JAMA Pediatr. 2015; 169, 154–162.CrossRefGoogle ScholarPubMed
Pinheiro, TV, Brunetto, S, Ramos, JGL, Bernardi, JR, Goldani, MZ. Hypertensive disorders during pregnancy and health outcomes in the offspring: a systematic review. J Dev Orig Health Dis. 2016; 7, 391–407.CrossRefGoogle ScholarPubMed
Whitehouse, AJ, Robinson, M, Newnham, JP, et al. Do hypertensive diseases of pregnancy disrupt neurocognitive development in offspring. Paediatr Perinat Epidemiol. 2012; 26, 101–108.CrossRefGoogle ScholarPubMed
Sverrisson, FA, Bateman, BT, Aspelund, T, Skulason, S, Zoega, H. Preeclampsia and academic performance in children: a nationwide study from Iceland. PLoS One. 2018; 13, e0207884.CrossRefGoogle ScholarPubMed
Armaly, Z, Jadaon, JE, Jabbour, A, Abassi, ZA. Preeclampsia: novel mechanisms and potential therapeutic approaches. Front Physiol. 2018; 9, 973.CrossRefGoogle ScholarPubMed
Ijomone, OK, Shallie, PD, Naicker, T. Oligodendrocytes death induced sensorimotor and cognitive deficit in N-nitro-L-arginine methyl rat model of pre-eclampsia. Neurochem Res. 2020; 45, 902–914.CrossRefGoogle ScholarPubMed
Figueiró-Filho, EA, Croy, BA, Reynolds, JN, et al. Diffusion tensor imaging of white matter in children born from preeclamptic gestations. AJNR Am J Neuroradiol. 2017; 38, 801–806.CrossRefGoogle ScholarPubMed