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Maternal gestational diabetes mellitus and overweight and obesity in offspring: a study in Chinese children

Published online by Cambridge University Press:  26 October 2015

Y. L. Zhao ,
R. M. Ma ,
T. T. Lao ,
Z. Chen ,
M. Y. Du ,
K. Liang ,
Y. K. Huang ,
L. Zhang ,
M. H. Yang  and
Y. H. Sun
...Show all authors
Y. L. Zhao
Affiliation:
Department of Obstetrics and Gynecology, First Affiliated Hospital of Kunming Medical University, Kunming, P.R. China
R. M. Ma*
Affiliation:
Department of Obstetrics and Gynecology, First Affiliated Hospital of Kunming Medical University, Kunming, P.R. China
T. T. Lao
Affiliation:
Department of Obstetrics and Gynecology, Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, P.R. China
Z. Chen
Affiliation:
Department of Obstetrics and Gynecology, First Affiliated Hospital of Kunming Medical University, Kunming, P.R. China
M. Y. Du
Affiliation:
Department of Obstetrics and Gynecology, First Affiliated Hospital of Kunming Medical University, Kunming, P.R. China
K. Liang
Affiliation:
Department of Pediatrics, First Affiliated Hospital of Kunming Medical University, Kunming, P.R. China
Y. K. Huang
Affiliation:
Department of Pediatrics, First Affiliated Hospital of Kunming Medical University, Kunming, P.R. China
L. Zhang
Affiliation:
Department of Obstetrics and Gynecology, First Affiliated Hospital of Kunming Medical University, Kunming, P.R. China
M. H. Yang
Affiliation:
Department of Obstetrics and Gynecology, First Affiliated Hospital of Kunming Medical University, Kunming, P.R. China
Y. H. Sun
Affiliation:
Department of Obstetrics and Gynecology, First Affiliated Hospital of Kunming Medical University, Kunming, P.R. China
H. Li
Affiliation:
Department of Obstetrics and Gynecology, First Affiliated Hospital of Kunming Medical University, Kunming, P.R. China
Z. B. Ding
Affiliation:
Department of Pediatrics, First Affiliated Hospital of Kunming Medical University, Kunming, P.R. China
*
*Address for Correspondence: R. M. Ma, Department of Obstetrics and Gynecology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032 P.R. China. (Email marunmeikmmc@163.com)
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Abstract

The purpose of this study was to investigate the effects of maternal gestational diabetes mellitus (GDM) and breast feeding on childhood overweight and obesity in a mainland Chinese population. The incidence of and factors associated with overweight and obesity were compared between children of mothers with (n=1068) and without (n=1756) GDM. The independent roles of the associated factors were examined by multiple logistic regression analysis. The incidence of overweight was higher (16.6 v. 12.6%, P=0.002) in the GDM group, but that of obesity was not different (10.7 v. 12.0%, P=0.315). At age 1–2 and 2–5 years, no difference in overweight (11.0 v. 12.0%, P=0.917, and 15.7 v. 14.6%, P=0.693, respectively) was found, while obesity (8.0 v. 13.6%, P=0.019, and 8.4 v. 13.4%, P=0.014, respectively) was less frequent in the GDM offspring. At age 5–10 years, increased overweight (22.2 v. 12.1%, P<0.001) and obesity (15.9 v. 9.0%, P=0.001) were found in the GDM group, which was associated with maternal obesity, being born large-for-gestational age, male gender and formula feeding. After adjusting for confounding factors, GDM remained an independent determinant of offspring overweight and obesity (aOR 2.28, 95% CI 1.61–3.22), suggesting that the effects of GDM were independent of breast feeding, as well as of maternal obesity and birth size.

Keywords

childrengestational diabetes mellitusobesityoffspringoverweight
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 6 , Issue 6 , December 2015 , pp. 479 - 484
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2015 

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