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Hepatic calcifications in fetal population studied by autopsies in Bogota, Colombia

Published online by Cambridge University Press:  23 May 2017

M. Olaya-C ,
S. Aldana-M ,
M. Maya-G  and
F. Gil
M. Olaya-C*
Affiliation:
Department of Pathology, Pontificia Universidad Javeriana, Bogota, Colombia Department of Pathology, Hospital Universitario San Ignacio, Bogota, Colombia
S. Aldana-M
Affiliation:
Medical School, Research seedbed in Perinatal Medicine, Pontificia Universidad Javeriana, Bogota, Colombia
M. Maya-G
Affiliation:
Medical School, Research seedbed in Perinatal Medicine, Pontificia Universidad Javeriana, Bogota, Colombia
F. Gil
Affiliation:
Department of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogota, Colombia
*
*Address for correspondence: M. Olaya-C, Department of Pathology, Pontificia Universidad Javeriana, Kra 7 40-62, Bogota 11321, Colombia. (Email molaya@husi.org.co)
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Abstract

Fetal hepatic calcifications can be caused by infections, chromosomal disorders, thrombotic events, ischemic hepatic necrosis and subcapsular hematomas among others events. Its features and clinical significance are still not well known. We performed an observational study to describe fetal hepatic calcifications and its association with main clinical and histopathological findings from the fetal autopsy database, between 2007 and 2014. Raw odds ratio analysis was performed. We reviewed 591 fetal autopsies: 14 cases with hepatic calcifications, 102 fetuses with chromosomal disorders; 13 with diagnosis of TORSCH (toxoplasma, rubella, syphilis, cytomegalovirus, herpes virus 1 and 2, and others) and 207 with any abnormality in the umbilical cord (UC). The relation between hepatic calcifications and chromosomal disorders in our series had significance. It is known that hepatic calcifications are common in chromosomal disorders, transplacental infections and UC abnormalities, those conditions are risk factor for hepatic calcifications formation; we suggest hepatic calcifications should alert the pathologists in order to consider these etiologies in first instance.

Keywords

chromosome abnormalityfetal thrombotic vasculopathyintrauterine infectionliver calcificationliver diseases
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 8 , Issue 5: Themed Issue: Australian Perspectives: Outcomes from the 2016 ANZ , October 2017 , pp. 613 - 617
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2017 

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