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Formula derived Maillard reaction products in post-weaning intrauterine growth-restricted piglets induce developmental programming of hepatic oxidative stress independently of microRNA-21 and microRNA-155

Part of: French DOHaD DOHaD on International Women's Day 2020

Published online by Cambridge University Press:  09 January 2018

S. Firmin ,
G. Elmhiri ,
D. Crepin ,
M. Souidi ,
M. Taouis  and
L. Abdennebi-Najar
S. Firmin*
Affiliation:
Institut Polytechnique UniLaSalle, Beauvais, France
G. Elmhiri
Affiliation:
PRP-HOM/SRBE/LRTOX, Laboratoire de Radiotoxicologie Expérimentale, Fontenay-aux-Roses, France
D. Crepin
Affiliation:
Neuroendocrinologie Moléculaire de la Prise Alimentaire, Institut des Neurosciences Paris-Saclay (Neuro-PSI), CNRS et Université Paris-Saclay, Gif sur Yvette, France
M. Souidi
Affiliation:
PRP-HOM/SRBE/LRTOX, Laboratoire de Radiotoxicologie Expérimentale, Fontenay-aux-Roses, France
M. Taouis
Affiliation:
Neuroendocrinologie Moléculaire de la Prise Alimentaire, Institut des Neurosciences Paris-Saclay (Neuro-PSI), CNRS et Université Paris-Saclay, Gif sur Yvette, France
L. Abdennebi-Najar*
Affiliation:
SF-DOHaD, Vitry Chatillon, France Idele Institute, Rue de Bercy, Paris cedex 12, France
*
*Address for correspondence: S. Firmin, Institut Polytechnique UnilaSalle, Science de la Nutrition et Santé, 19 Rue Pierre Waguet, 60000 Beauvais, France. (Email stephane.firmin@unilasalle.fr) L. Abdennebi-Najar, IDELE Institute, rue de Bercy, 75595 Paris cedex 12, France. (Email latifa.Najar@idele.fr)
*Address for correspondence: S. Firmin, Institut Polytechnique UnilaSalle, Science de la Nutrition et Santé, 19 Rue Pierre Waguet, 60000 Beauvais, France. (Email stephane.firmin@unilasalle.fr) L. Abdennebi-Najar, IDELE Institute, rue de Bercy, 75595 Paris cedex 12, France. (Email latifa.Najar@idele.fr)
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Abstract

We recently reported augmentation of lipid peroxidation products in the liver of intrauterine growth-restricted (IUGR) piglets fed a high load of Maillard reaction products (MRPs) during suckling period. The underlying mechanisms of MRPs effects remain unknown. Here, we studied the long-term impact of MRPs exposure on liver oxidative status of IUGR juvenile pigs. Livers of 54-day-old pigs suckled with formula containing either a high (HHF, n=8) or a low (LHF: n=8) load of MRPs were analyzed for protein carbonylation levels , activities and messenger RNA (mRNA) expression of glutathione (GSH) and main antioxidant regulators of redox homeostasis [Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were measured. In addition, mRNA levels of miRNA-21 and miRNA-155 were measured. The liver of HHF group exhibited a high level of lipid peroxidation with significantly increased expression and activity of SOD. Further in liver of HHF group, CAT activity was decreased as compared with LHF group, though with comparable total protein carbonyl contents, GSH contents, and expression of GPx and microRNAs (miRNA-21 and miRNA-155). Our findings suggest that the potential mechanism of MRPs-mediated oxidative stress programming in liver of IUGR piglets may occur via impairment of antioxidant defenses.

Keywords

dietary MRPsIUGRmilk formulaoxidative stressprogramming
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 9 , Issue 6 , December 2018 , pp. 566 - 572
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018 

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