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Effect of maternal zinc supplementation on the cardiometabolic profile of Peruvian children: results from a randomized clinical trial

Published online by Cambridge University Press:  17 October 2016

M. L. Mispireta ,
L. E. Caulfield ,
N. Zavaleta ,
M. Merialdi ,
D. L. Putnick ,
M. H. Bornstein  and
J. A. DiPietro
M. L. Mispireta
Affiliation:
Kasiska School of Health Professions, Idaho State University, Pocatello, ID, USA Department of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
L. E. Caulfield*
Affiliation:
Department of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
N. Zavaleta
Affiliation:
Instituto de Investigación Nutricional, Lima, Peru
M. Merialdi
Affiliation:
Global Health Division, Becton Dickinson, Franklin Lakes, NJ, USA
D. L. Putnick
Affiliation:
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
M. H. Bornstein
Affiliation:
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
J. A. DiPietro
Affiliation:
Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
*
*Address for correspondence: L. E. Caulfield, Department of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room W2041, Baltimore, MD 21205, USA. (Email lcaulfi1@jhu.edu)
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Abstract

Zinc is an essential micronutrient for the development of the fetal renal, cardiovascular and metabolic systems; however, there is limited evidence of its effects on the postnatal cardiometabolic function. In this study, we evaluated the effect of maternal zinc supplementation during pregnancy on the cardiometabolic profile of the offspring in childhood. A total of 242 pregnant women were randomly assigned to receive a daily supplement containing iron+folic acid with or without zinc. A follow-up study was conducted when children of participating mothers were 4.5 years of age to evaluate their cardiometabolic profile, including anthropometric measures of body size and composition, blood pressure, lipid profile and insulin resistance. No difference in measures of child cardiometabolic risk depending on whether mothers received supplemental zinc during pregnancy. Our results do not support the hypothesis that maternal zinc supplementation reduces the risk of offspring cardiometabolic disease.

Keywords

cardiovascularmetaboliczinc
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 8 , Issue 1 , February 2017 , pp. 56 - 64
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2016. This is a work of the U.S. Government and is not subject to copyright protection in the United States. 

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