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Branched-chain amino acid supplemented diet during maternal food restriction prevents developmental hypertension in adult rat offspring

Published online by Cambridge University Press:  28 January 2011

T. Fujii ,
S. Yura ,
K. Tatsumi ,
E. Kondoh ,
H. Mogami ,
K. Fujita ,
K. Kakui ,
S. Aoe ,
H. Itoh  and
N. Sagawa
...Show all authors
T. Fujii
Affiliation:
Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
S. Yura*
Affiliation:
Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), Saitama, Japan
K. Tatsumi
Affiliation:
Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
E. Kondoh
Affiliation:
Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
H. Mogami
Affiliation:
Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
K. Fujita
Affiliation:
Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
K. Kakui
Affiliation:
Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
S. Aoe
Affiliation:
Department of Home Economics, Otsuma Women's University, 12, Sanban-cho, Chiyoda-ku, Tokyo, Japan
H. Itoh
Affiliation:
Department of Obstetrics and Gynecology, Hamamatsu University, School of Medicine, Hamamatsu, Japan
N. Sagawa
Affiliation:
Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Tsu, Japan
S. Fujii
Affiliation:
Department of Gynecology and Obstetrics, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan
I. Konishi
Affiliation:
Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
*
*Address for correspondence: S. Yura, MD, PhD, Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. (Email psuka@kuhp.kyoto-u.ac.jp)
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Abstract

Maternal food restriction is known to cause developmental hypertension in offspring. We have previously shown that maternal high-protein diet can reverse fetal programming of hypertension and that branched-chain amino acid (BCAA) concentrations in maternal and fetal plasma were increased by maternal high-protein intake. Then, we hypothesized that isocaloric supplementation with BCAA to a maternal food restriction can reverse the adverse outcome. Pregnant rats were divided into four groups at 7.5 days postcoitum: normally nourished (NN) and 70% undernourished (UN) groups with and without BCAA supplementation (NN–standard diet (SD), NN–BCAA, UN–SD and UN–BCAA groups). Compared with pups in the NN groups, those in the UN–SD group had significantly increased systolic blood pressure (SBP) at 8 and 16 weeks of age (P < 0.05). However, the elevation of SBP was not observed in offspring in the UN–BCAA group. Offspring glomeruli number of the UN groups was significantly lower (P < 0.05) than that of the NN groups, independent of BCAA supplementation. Angiotensin II receptor type 2 (ATR2) mRNA and protein expression in the kidney was significantly augmented in the UN–BCAA group at 30 weeks of age. In conclusion, BCAA supplementation during maternal food restriction prevents developmental hypertension together with increased ATR2 expression in adult offspring kidney.

Keywords

angiotensin II receptorbranched chain amino acidsintrauterine undernutritionmaternal food restrictionsystolic blood pressure
Type
Original Articles
Information
Journal of Developmental Origins of Health and Disease , Volume 2 , Issue 3 , June 2011 , pp. 176 - 183
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2011

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