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At the heart of programming: the role of micro-RNAs

Part of: French DOHaD DOHaD on International Women's Day 2020

Published online by Cambridge University Press:  18 June 2018

B. Siddeek ,
C. Mauduit ,
C. Yzydorczyk ,
M. Benahmed  and
U. Simeoni
B. Siddeek*
Affiliation:
Woman-Mother-Child-Department, Division of Pediatrics, DOHaD Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
C. Mauduit
Affiliation:
INSERM U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), Team 5, Nice, France
C. Yzydorczyk
Affiliation:
Woman-Mother-Child-Department, Division of Pediatrics, DOHaD Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
M. Benahmed
Affiliation:
INSERM U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), Team 5, Nice, France
U. Simeoni
Affiliation:
Woman-Mother-Child-Department, Division of Pediatrics, DOHaD Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
*
Address for correspondence: Benazir Siddeek, Woman-Mother-Child-Department, Division of Pediatrics, DOHaD Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 27, 1011, Lausanne, Switzerland. E-mail: Benazir.Siddeek@chuv.ch
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Abstract

Epidemiological and experimental observations tend to prove that environment, lifestyle or nutritional challenges influence heart functions together with genetic factors. Furthermore, when occurring during sensitive windows of heart development, these environmental challenges can induce an ‘altered programming’ of heart development and shape the future heart disease risk. In the etiology of heart diseases driven by environmental challenges, epigenetics has been highlighted as an underlying mechanism, constituting a bridge between environment and heart health. In particular, micro-RNAs which are involved in each step of heart development and functions seem to play a crucial role in the unfavorable programming of heart diseases. This review describes the latest advances in micro-RNA research in heart diseases driven by early exposure to challenges and discusses the use of micro-RNAs as potential targets in the reversal of the pathophysiology.

Keywords

cardio-metabolic dysfunctionsmicro-RNAsprogrammingreversal
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 9 , Issue 6 , December 2018 , pp. 615 - 631
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2018 

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