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The response of male and female rats to a high-fructose diet during adolescence following early administration of Hibiscus sabdariffa aqueous calyx extracts

Published online by Cambridge University Press:  19 June 2017

K. G. Ibrahim
Affiliation:
School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Department of Physiology, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
E. Chivandi
Affiliation:
School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
F. B. O. Mojiminiyi
Affiliation:
Department of Physiology, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
K. H. Erlwanger
Affiliation:
School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Corresponding

Abstract

Metabolic syndrome is linked to the consumption of fructose-rich diets. Nutritional and pharmacological interventions perinatally can cause epigenetic changes that programme an individual to predispose or protect them from the development of metabolic diseases later. Hibiscus sabdariffa (HS) reportedly has anti-obesity and hypocholesterolaemic properties in adults. We investigated the impact of neonatal intake of HS on the programming of metabolism by fructose. A total of 85 4-day-old Sprague Dawley rats were divided randomly into three groups. The control group (n=27, 12 males, 15 females) received distilled water at 10 ml/kg body weight. The other groups received either 50 mg/kg (n=30, 13 males, 17 females) or 500 mg/kg (n=28, 11 males, 17 females) of an HS aqueous calyx extract orally till postnatal day (PND) 14. There was no intervention from PND 14 to PND 21 when the pups were weaned. The rats in each group were then divided into two groups; one continued on a normal diet and the other received fructose (20% w/v) in their drinking water for 30 days. The female rats that were administered with HS aqueous calyx extract as neonates were protected against fructose-induced hypertriglyceridaemia and increased liver lipid deposition. The early administration of HS resulted in a significant (P⩽0.05) increase in plasma cholesterol concentrations with or without a secondary fructose insult. In males, HS prevented the development of fructose-induced hypercholesterolaemia. The potential beneficial and detrimental effects of neonatal HS administration on the programming of metabolism in rats need to be considered in the long-term well-being of children.

Type
Original Article
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2017 

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References

1. Armitage, JA, Khan, IY, Taylor, PD, Nathanielsz, PW, Poston, L. Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals? J Physiol. 2004; 561, 355377.CrossRefGoogle ScholarPubMed
2. Ebbeling, CB, Pawlak, DB, Ludwig, DS. Childhood obesity: public-health crisis, common sense cure. Lancet. 2002; 360, 473482.CrossRefGoogle ScholarPubMed
3. Gluckman, PD, Hanson, MA. The developmental origins of the metabolic syndrome. Trends Endocrinol Metab. 2004; 15, 183187.CrossRefGoogle ScholarPubMed
4. Hales, CN, Barker, DJ. The thrifty phenotype hypothesis. Br Med Bull. 2001; 60, 520.CrossRefGoogle ScholarPubMed
5. Osmond, C, Barker, D, Winter, P, Fall, C, Simmonds, S. Early growth and death from cardiovascular disease in women. BMJ. 1993; 307, 15191524.CrossRefGoogle ScholarPubMed
6. Hales, CN, Barker, DJP. Type 2 (noninsulin dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia. 1992; 35, 595601.CrossRefGoogle Scholar
7. Moura, EG, Passos, MC. Neonatal programming of body weight regulation and energetic metabolism. Biosci Rep. 2005; 25, 251269.CrossRefGoogle ScholarPubMed
8. Rooney, K, Ozanne, S. Maternal over-nutrition and offspring obesity predisposition: targets for preventative interventions. Int J Obes. 2011; 35, 883890.CrossRefGoogle ScholarPubMed
9. Alfaradhi, M, Ozanne, S. Developmental programming in response to maternal overnutrition. Front Genet. 2011; 2, 27.CrossRefGoogle ScholarPubMed
10. Armitage, JA, Taylor, PD, Poston, L. Experimental models of developmental programming: consequences of exposure to an energy rich diet during development. J Physiol. 2005; 565, 38.CrossRefGoogle Scholar
11. Scarpellini, E, Campanale, M, Leone, D, et al. Gut microbiota and obesity. Intern Emerg Med. 2010; 5, 5356.CrossRefGoogle ScholarPubMed
12. Schmidt, I, Fritz, A, Schölch, C, et al. The effect of leptin treatment on the development of obesity in overfed suckling Wistar rats. Int J Obes Relat Metab Disord. 2001; 25, 11681174.CrossRefGoogle ScholarPubMed
13. Khan, IY, Dekou, V, Douglas, G, et al. A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring. Am J Physiol Regul Integr Comp Physiol. 2005; 288, R127R133.CrossRefGoogle ScholarPubMed
14. Pico, C, Oliver, P, Sanchez, J, et al. The intake of physiological doses of leptin during lactation in rats prevents obesity in later life. Int J Obes. 2007; 31, 11991209.CrossRefGoogle ScholarPubMed
15. Kelishadi, R, Mansourian, M, Heidari-Beni, M. Association of fructose consumption and components of metabolic syndrome in human studies: a systematic review and meta-analysis. Nutrition. 2014; 30, 503510.CrossRefGoogle ScholarPubMed
16. Angelova, P, Boyadjiev, N. A review on the models of obesity and metabolic syndrome in rats. Trak J Sci. 2013; 11, 512.Google Scholar
17. Abdulla, MH, Sattar, MA, Johns, EJ. The relation between fructose-induced metabolic syndrome and altered renal haemodynamic and excretory function in the rat. Int J Nephrol. 2011; 2011, 117.CrossRefGoogle ScholarPubMed
18. de Moura, RF, Ribeiro, C, de Oliveira, JA, Stevanato, E, de Mello, MAR. Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols. Br J Nutr. 2009; 101, 11781184.CrossRefGoogle ScholarPubMed
19. Busserolles, J, Mazur, A, Gueux, E, Rock, E, Rayssiguier, Y. Metabolic syndrome in the rat: females are protected against the pro-oxidant effect of a high sucrose diet. Exp Biol Med. 2002; 227, 837842.CrossRefGoogle ScholarPubMed
20. Galipeau, D, Verma, S, McNeill, JH. Female rats are protected against fructose-induced changes in metabolism and blood pressure. Am J Physiol Heart Circ Physiol. 2002; 283, H2478H2484.CrossRefGoogle ScholarPubMed
21. Korićanac, G, Đorđević, A, Žakula, Z, et al. Gender modulates development of the metabolic syndrome phenotype in fructose-fed rats. Arch Bio Sci. 2013; 65, 455464.CrossRefGoogle Scholar
22. Teff, KL, Elliott, SS, Tschöp, M, et al. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab. 2004; 89, 29632972.CrossRefGoogle ScholarPubMed
23. Mahadevan, N, Shivali, KP, Kamboj, P. Hibiscus sabdariffa Linn: an overview. Nat Prod Rad. 2009; 8, 7783.Google Scholar
24. Mojiminiyi, FBO, Audu, Z, Etuk, EU, et al. Attenuation of salt-induced hypertension by aqueous calyx extract of Hibiscus Sabdariffa . Niger J Physiol Sci. 2012; 2, 195200.Google Scholar
25. Alarcon-Aguilar, FJ, Zamilpa, A, Perez-Garcia, MD, et al. Effects of Hibiscus sabdariffa on obeisity in MSG mice. J Ethnopharmacol. 2007; 114, 6671.CrossRefGoogle Scholar
26. Da-Costa-Rocha, I, Bonnlaender, B, Sievers, H, et al. Hibiscus sabdariffa L. – a phytochemical and pharmacological review. Food Chem. 2014; 165, 424443.CrossRefGoogle Scholar
27. Patel, S. Hibiscus sabdariffa: an ideal yet under-exploited candidate for nutraceutical applications. Biomed Prev Nutr. 2014; 4, 2327.CrossRefGoogle Scholar
28. Kim, J-K, So, H, Youn, M-J, et al. Hibiscus sabdariffa L. water extract inhibits the adipocyte differentiation through the PI3-K and MAPK pathway. J Ethnopharmacol. 2007; 114, 260267.CrossRefGoogle ScholarPubMed
29. Carvajal-Zarrabal, O, Hayward-Jones, P, Orta-Flores, Z, et al. Effect of Hibiscus sabdariffa L. dried calyx ethanol extract on fat absorption-excretion, and body weight implication in rats. Biomed Res Int. 2009; 2009, 5.Google ScholarPubMed
30. Onyenekwe, PC, Ajani, EO, Ameh, DA, Gamaliel, KS. Antihypertensive effect of roselle (Hibiscus sabdariffa) calyx infusion in SHR and a comparism of its toxicity with that in Wistar rats. Cell Biochem Funct. 1999; 17, 199206.3.0.CO;2-2>CrossRefGoogle Scholar
31. Mojiminiyi, FBO, Dikko, M, Muhammad, BY, et al. Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa . Fitoterapia. 2007; 78, 292297.CrossRefGoogle ScholarPubMed
32. Peng, C-H, Chyau, C-C, Chan, K-C, et al. Hibiscus sabdariffa polyphenolic extract inhibits hyperglycemia, hyperlipidemia, and glycation-oxidative stress while improving insulin resistance. J Agric Food Chem. 2011; 59, 99019909.CrossRefGoogle ScholarPubMed
33. Adisakwattana, S, Ruengsamran, T, Kampa, P, Sompong, W. In vitro inhibitory effects of plant-based foods and their combinations on intestinal alpha-glucosidase and pancreatic alpha-amylase. BMC Complement Altern Med. 2012; 12, 110.CrossRefGoogle ScholarPubMed
34. Lin, T-L, Lin, H-H, Chen, C-C, et al. Hibiscus sabdariffa extract reduces serum cholesterol in men and women. Nutr Res. 2007; 27, 140145.CrossRefGoogle Scholar
35. Gurrola-Daiz, CM, Garcia-Lopez, PM, Sanchez Enriquez, S, et al. Effects of Hibiscus sabdariffa powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome. Phytomedicine. 2010; 17, 500505.CrossRefGoogle Scholar
36. Tseng, T-H, Hsu, J-D, Lo, M-H, et al. Inhibitory effects of Hibiscus protocatechuic acid on tumour promotion in mouse skin. Cancer Lett. 1998; 126, 199207.CrossRefGoogle ScholarPubMed
37. Gaya, I, Mohammad, O, Suleiman, A, Maje, M, Adekunle, A. Toxicological and lactogenic studies on the seeds of Hibiscus sabdariffa linn (Malvaceae) extract on serum prolactin levels of albino wistar rats. Internet J Endocrinol. 2009; 5, 6.Google Scholar
38. Ndu, OO, Nworu, CS, Ehiemere, CO, Ndukwe, NC, Ochiogu, IS. Herb–drug interaction between the extract of Hibiscus sabdariffa L. and hydrochlorothiazide in experimental animals. J Med Food. 2011; 14, 640644.CrossRefGoogle ScholarPubMed
39. Dangarembizi, R, Erlwanger, KH, Chivandi, E. Effects of Ficus thonningii extracts on the gastrointestinal tract and clinical biochemistry of suckling rats. Afr J Tradit Complement Altern Med. 2014; 11, 285291.CrossRefGoogle ScholarPubMed
40. Ali, BH, Mousa, HM, El-Mougy, S. The effect of a water extract and anthocyanins of Hibiscus sabdariffa L. on paracetamol-induced hepatoxicity in rats. Phytother Res. 2003; 17, 5659.CrossRefGoogle ScholarPubMed
41. Chaturvedi, P, George, S, Milinganyo, M, Tripathi, YB. Effect of Momordica charantia on lipid profile and oral glucose tolerance in diabetic rats. Phytother Res. 2004; 18, 954956.CrossRefGoogle ScholarPubMed
42. Matthews, D, Hosker, J, Rudenski, A, et al. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985; 28, 412419.CrossRefGoogle ScholarPubMed
43. Bligh, EG, Dyer, WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959; 37, 911917.CrossRefGoogle ScholarPubMed
44. Passonneau, JV, Lauderdale, VR. A comparison of three methods of glycogen measurement in tissues. Anal Biochem. 1974; 60, 405412.CrossRefGoogle ScholarPubMed
45. Iyare, EE, Adegoke, OA. Postnatal weight gain and onset of puberty in rats exposed to aqueous extracts of Hibiscus sabdariffa in utero. Pak J Nutr. 2008; 7, 98101.CrossRefGoogle Scholar
46. Iyare, EE, Nwagha, UI. Postweaning consumption of aqueous extract of Hibiscus sabdariffa may predispose rats to obesity. Pak J Nutr. 2009; 8, 17601765.Google Scholar
47. Miettinen, TA. Cholesterol production in obesity. Circulation. 1971; 44, 842851.CrossRefGoogle ScholarPubMed
48. Stanhope, KL, Havel, PJ. Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance. Curr Opin Lipidol. 2008; 19, 1624.CrossRefGoogle ScholarPubMed
49. Conlee, R, Lawler, R, Ross, P. Effects of glucose or fructose feeding on glycogen repletion in muscle and liver after exercise or fasting. Ann Nutr Metab. 1987; 31, 126132.CrossRefGoogle ScholarPubMed
50. Koo, H-Y, Wallig, MA, Chung, BH, et al. Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver. Biochim Biophys Acta. 2008; 1782, 341348.CrossRefGoogle ScholarPubMed
51. Eden, S. Age- and sex-related differences in episodic growth hormone secretion in the rat. Endocrinology. 1979; 105, 555560.CrossRefGoogle ScholarPubMed
52. Gabriel, S, Roncancio, J, Ruiz, N. Growth hormone pulsatility and the endocrine milieu during sexual maturation in male and female rats. Neuroendocrinology. 1992; 56, 619628.CrossRefGoogle ScholarPubMed
53. Ellis, J, Hollands, T, Allen, D. Effect of forage intake on bodyweight and performance. Equine Vet J. 2002; 34, 6670.CrossRefGoogle Scholar
54. MacCracken, JG, Stebbings, JL. Test of a body condition index with amphibians. J Herpetol. 2012; 46, 346350.CrossRefGoogle Scholar
55. Baum, HBA, Biller, BMK, Finkelstein, JS, et al. Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. A randomized, placebo-controlled trial. Ann Intern Med. 1996; 125, 883890.CrossRefGoogle Scholar
56. Eshet, R, Maor, G, Ari, TB, et al. The aromatase inhibitor letrozole increases epiphyseal growth plate height and tibial length in peripubertal male mice. J Endocrinol. 2004; 182, 165172.CrossRefGoogle ScholarPubMed
57. N.C.E.P. Third report of the National Cholesterol Education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treament panel III). Final report. 2002.Google Scholar
58. Tobey, T, Mondon, C, Zavaroni, I, Reaven, G. Mechanism of insulin resistance in fructose-fed rats. Metabolism. 1982; 31, 608612.CrossRefGoogle ScholarPubMed
59. Nakagawa, T, Hu, H, Zharikov, S, et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol. 2006; 290, F625F631.CrossRefGoogle ScholarPubMed
60. Motoyama, CS, Pinto, MJ, Lira, FS, et al. Gum Guar fiber associated with fructose reduces serum triacylglycerol but did not improve the glucose tolerance in rats. Diabetol Metab Syndr. 2010; 2, 117.CrossRefGoogle Scholar
61. Michalopoulos, GK. Liver regeneration. J Cell Physiol. 2007; 213, 286300.CrossRefGoogle ScholarPubMed
62. Sawchenko, P, Mark, I. Sensory functions of the liver: a review. Am J Physiol. 1979; 236, R5R20.Google ScholarPubMed
63. Sallie, R, Michael Tredger, J, Williams, R. Drugs and the liver part 1: testing liver function. Biopharm Drug Dispos. 1991; 12, 251259.CrossRefGoogle ScholarPubMed
64. Seyama, Y, Kokudo, N. Assessment of liver function for safe hepatic resection. Hepatol Res. 2009; 39, 107116.CrossRefGoogle ScholarPubMed
65. Kelley, GL, Allan, G, Azhar, S. High dietary fructose induces a hepatic stress response resulting in cholesterol and lipid dysregulation. Endocrinology. 2004; 145, 548555.CrossRefGoogle ScholarPubMed
66. Thapa, B, Walia, A. Liver function tests and their interpretation. Indian J Pediatr. 2007; 74, 663671.CrossRefGoogle ScholarPubMed
67. Thulin, P, Rafter, I, Stockling, K, et al. PPARα regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes. Toxicol Appl Pharmacol. 2008; 231, 19.CrossRefGoogle ScholarPubMed
68. Rajesh, S, Rajkapoor, B, Kumar, RS, Raju, K. Effect of Clausena dentata (Willd.) M. Roem. against paracetamol induced hepatotoxicity in rats. Pak J Pharm Sci. 2009; 22, 9093.Google ScholarPubMed
69. Pratt, DS, Kaplan, MM. Evaluation of abnormal liver-enzyme results in asymptomatic patients. N Engl J Med. 2000; 342, 12661271.CrossRefGoogle ScholarPubMed
70. de Castro, U, Dos Santos, R, Silva, ME, et al. Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats. Lipids Health Dis. 2013; 12, 111.CrossRefGoogle ScholarPubMed
71. West, JR. Foetal alcohol-induced brain damage and the problem of determining temporal vulnerability: a review. Alcohol Drug Res. 1987; 7, 423441.Google Scholar
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The response of male and female rats to a high-fructose diet during adolescence following early administration of Hibiscus sabdariffa aqueous calyx extracts
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