Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-17T19:37:52.922Z Has data issue: false hasContentIssue false
  • English
  • Français

Cardiac and vascular health in late preterm infants

Published online by Cambridge University Press:  19 March 2021

Hasthi U. Dissanayake Open the ORCID record for Hasthi U. Dissanayake [Opens in a new window] ,
Rowena L. McMullan ,
Yang Kong ,
Ian D. Caterson ,
David S. Celermajer ,
Melinda Phang ,
Camille Raynes-Greenow ,
Jaimie W. Polson ,
Adrienne Gordon  and
Michael R. Skilton Open the ORCID record for Michael R. Skilton [Opens in a new window]
Hasthi U. Dissanayake*
Affiliation:
Faculty of Medicine and Health, Boden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, The University of Sydney, Sydney, NSW 2006, Australia Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia
Rowena L. McMullan
Affiliation:
Faculty of Medicine and Health, Boden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, The University of Sydney, Sydney, NSW 2006, Australia Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia Department of Neonatology, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia
Yang Kong
Affiliation:
Faculty of Medicine and Health, Boden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, The University of Sydney, Sydney, NSW 2006, Australia Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia
Ian D. Caterson
Affiliation:
Faculty of Medicine and Health, Boden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, The University of Sydney, Sydney, NSW 2006, Australia
David S. Celermajer
Affiliation:
Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia Department of Cardiology, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia
Melinda Phang
Affiliation:
Faculty of Medicine and Health, Boden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, The University of Sydney, Sydney, NSW 2006, Australia
Camille Raynes-Greenow
Affiliation:
Sydney School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia
Jaimie W. Polson
Affiliation:
Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia School of Medical Sciences, Medical Foundation Building, The University of Sydney, Sydney NSW 2006, Australia
Adrienne Gordon
Affiliation:
Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia Department of Neonatology, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia
Michael R. Skilton
Affiliation:
Faculty of Medicine and Health, Boden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, The University of Sydney, Sydney, NSW 2006, Australia Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia
*
Address for correspondence: Hasthi U. Dissanayake, Faculty of Medicine and Health, Boden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, The University of Sydney, Sydney, NSW 2006, Australia. Email hasthi.dissanayake@sydney.edu.au
Get access Rights & Permissions [Opens in a new window]

Abstract

Adults who were born preterm are at increased risk of hypertension and cardiovascular disease in later life. Infants born late preterm are the majority of preterm births; however, the effect of late preterm on risk of cardiovascular disease is unclear. The objective of this study was to assess whether vascular health and cardiac autonomic control differ in a group of late preterm newborn infants compared to a group of term-born infants.

A total of 35 healthy late preterm newborn infants, with normal growth (34–36 completed weeks’ gestation) and 139 term-born infants (37–42 weeks’ gestation) were compared in this study. Aortic wall thickening, assessed as aortic intima–media thickness (IMT) by high-resolution ultrasound, and cardiac autonomic control, assessed by heart rate variability, were measured during the first week of life. Postnatal age of full-term and late preterm infants at the time of the study was 5 days (standard deviation [SD] 5) and 4 days (SD 3), respectively.

Infants born late preterm show reduced aortic IMT (574 μm [SD 51] vs. 612 μm [SD 73]) and reduced heart rate variability [log total power 622.3 (606.5) ms2 vs. 1180. 6 (1114.3) ms2], compared to term infants. These associations remained even after adjustment for sex and birth weight.

Infants born late preterm show selective differences in markers of cardiovascular risk, with potentially beneficial differences in aortic wall thickness in contrast to potentially detrimental differences in autonomic control, when compared with term-born control infants. These findings provide pathophysiologic evidence to support an increased risk of hypertension and sudden cardiac death in individuals born late preterm.

Keywords

Late pretermcardiovascular diseaseaortic intima–media thicknesscardiac autonomic control
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 13 , Issue 1 , February 2022 , pp. 128 - 134
Check for updates
Copyright
© The Author(s), 2021. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Hasthi U. Dissanayake and Rowena L. McMullan contributed equally.

†

Joint first authors.

References

Blencowe, H, Cousens, S, Chou, D, et al. Born too soon: the global epidemiology of 15 million preterm births. Reprod Health. 2013; 10(Suppl 1), S2.CrossRefGoogle ScholarPubMed
Hilder, L., Zhichao, Z, Parker, M, Jahan, S, Chambers, GM. Australia’s Mothers and Babies 2012, P.s.s.n. 30, Editor. 2014, Australian Institute of Health and Welfare, Canberra.Google Scholar
Martin, JA, Hamilton, BE, Osterman, MJK, Driscoll, AK, Mathews, TJ. Births: final Data for 2015. Natl Vital Stat Rep. 2017; 66(1), 1.Google ScholarPubMed
Kramer, MS, Demissie, K, Yang, H, Platt, RW, Sauvé, R, Liston, R. The contribution of mild and moderate preterm birth to infant mortality. Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System. JAMA. 2000; 284(7), 843–849.CrossRefGoogle Scholar
Teune, MJ, Bakhuizen, S, Bannerman, CG. A systematic review of severe morbidity in infants born late preterm. Am J Obstet Gynecol. 2011; 205(4), 374 e1–9.CrossRefGoogle ScholarPubMed
Bentley, JP, Roberts, CL, Bowen, JR, Martin, AJ, Morris, JM, Nassar, N. Planned birth before 39 weeks and child development: a population-based study. Pediatrics. 2016; 138(6).CrossRefGoogle ScholarPubMed
Quigley, MA, Poulsen, G, Boyle, E, et al. Early term and late preterm birth are associated with poorer school performance at age 5 years: a cohort study. Arch Dis Child Fetal Neonatal Ed. 2012; 97(3), F167–F173.CrossRefGoogle ScholarPubMed
Lewandowski, AJ, Levy, PT, Bates, ML, et al. Impact of the vulnerable preterm heart and circulation on adult cardiovascular disease risk. Hypertension. 2020; 76(4), 1028–1037.CrossRefGoogle ScholarPubMed
Crump, C, Howell, EA, Stroustrup, A, McLaughlin, MA, Sundquist, J, Sundquist, K. Association of preterm birth with risk of ischemic heart disease in adulthood. JAMA Pediatr. 2019; 173(8), 736–743.CrossRefGoogle ScholarPubMed
Carr, H, Cnattingius, S, Granath, F, Ludvigsson, JF, Bonamy, A-KE. Preterm birth and risk of heart failure up to early adulthood. J Am Coll Cardiol. 2017; 69(21), 2634–2642.CrossRefGoogle ScholarPubMed
Skilton, MR, Viikari, JS, Juonala, M, et al. Fetal growth and preterm birth influence cardiovascular risk factors and arterial health in young adults: the Cardiovascular Risk in Young Finns Study. Arterioscler Thromb Vasc Biol. 2011; 31(12), 2975–2981.CrossRefGoogle ScholarPubMed
Mikkola, K, Leipala, J, Boldt, T, Fellman, V. Fetal growth restriction in preterm infants and cardiovascular function at five years of age. J Pediatr. 2007; 151(5), 494–9, 499 e1–2.CrossRefGoogle ScholarPubMed
Lewandowski, AJ, Augustine, D, Lamata, P, et al. Preterm heart in adult life: cardiovascular magnetic resonance reveals distinct differences in left ventricular mass, geometry, and function. Circulation. 2013; 127(2), 197–206.CrossRefGoogle ScholarPubMed
Lewandowski, AJ, Bradlow, WM, Augustine, D, et al. Right ventricular systolic dysfunction in young adults born preterm. Circulation. 2013; 128(7), 713–720.CrossRefGoogle ScholarPubMed
Andriessen, P, Oetomo, SB, Peters, C, Vermeulen, B, Pieter, FFW, Blanco, CE. Baroreceptor reflex sensitivity in human neonates: the effect of postmenstrual age. J Physiol. 2005; 568(1), 333–341.CrossRefGoogle ScholarPubMed
Mathewson, KJ, Van Lieshout, RJ, Saigal, S, Boyle, MH, Schmidt, LA. Reduced respiratory sinus arrhythmia in adults born at extremely low birth weight: Evidence of premature parasympathetic decline? Int J Psychophysiol. 2014; 93(2), 198–203.CrossRefGoogle ScholarPubMed
Patural, H, Barthelemy, JC, Pichot, V, et al. Birth prematurity determines prolonged autonomic nervous system immaturity. Clin Auton Res. 2004; 14(6), 391–395.CrossRefGoogle ScholarPubMed
Rakow, A, Katz-Salamon, M, Ericson, M, Edner, A, Vanpée, M. Decreased heart rate variability in children born with low birth weight. Pediatr Res. 2013; 74(3), 339–343.CrossRefGoogle ScholarPubMed
Yiallourou, SR, Witcombe, NB, Sands, SA, Walker, AM, Horne, RSC. The development of autonomic cardiovascular control is altered by preterm birth. Early Hum Dev. 2013; 89(3), 145–152.CrossRefGoogle ScholarPubMed
Dissanayake, H, McMullan, R, Kong, Y, et al. Body fatness and cardiovascular health in newborn infants. J Clin Med. 2018; 7(9), 270.CrossRefGoogle ScholarPubMed
Fields, DA, Gunatilake, R, Kalaitzoglou, E. Air displacement plethysmography: cradle to grave. Nutr Clin Pract. 2015; 30(2), 219–226.CrossRefGoogle ScholarPubMed
Ma, G, Yao, M, Liu, Y, et al. Validation of a new pediatric air-displacement plethysmograph for assessing body composition in infants. Am J Clin Nutr. 2004; 79(4), 653–660.CrossRefGoogle ScholarPubMed
Roggero, P, Gianni, ML, Amato, O, et al. Evaluation of air-displacement plethysmography for body composition assessment in preterm infants. Pediatr Res. 2012; 72(3), 316–320.CrossRefGoogle ScholarPubMed
Ellis, KJ, Yao, M, Shypailo, RJ, Urlando, A, Wong, WW, Heird, WC. Body-composition assessment in infancy: air-displacement plethysmography compared with a reference 4-compartment model. Am J Clin Nutr. 2007; 85(1), 90–95.CrossRefGoogle ScholarPubMed
Dobbins, TA, Sullivan, EA, Roberts, CL, Simpson, JM. Australian national birthweight percentiles by sex and gestational age, 1998–2007. Med J Aust. 2012; 197(5), 291–294.CrossRefGoogle ScholarPubMed
Skilton, MR, Celermajer, DS, Cosmi, E, et al. Natural history of atherosclerosis and abdominal aortic intima-media thickness: rationale, evidence, and best practice for detection of atherosclerosis in the young. J Clin Med. 2019; 8(8), 1201.CrossRefGoogle Scholar
Malik, M. Heart rate variability: standards of measurement, physiological interpretation, and clinical use: task force of The European Society of Cardiology and the North American Society for Pacing and Electrophysiology. Ann Noninvasive Electrocardiol. 1996; 1(2), 151–181.CrossRefGoogle Scholar
Polson, JW, McCallion, N, Waki, H, et al. Evidence for cardiovascular autonomic dysfunction in neonates with coarctation of the aorta. Circulation. 2006; 113(24), 2844–2850.CrossRefGoogle ScholarPubMed
Eg, R, Cassuto, Y, Zmora, E. Heart rate variability in the neonate and infant: analytical methods, physiological and clinical observations. Acta Paediatr. 1999; 88(5), 477–482.Google Scholar
Andriessen, P, Schoffelen, RL, Berendsen, RC, et al. Noninvasive assessment of blood pressure variability in preterm infants. Pediatr Res. 2004; 55(2), 220–223.CrossRefGoogle ScholarPubMed
Engle, WA, Tomashek, KM, Wallman, C, et al. “Late-Preterm” infants: a population at risk. Pediatr. 2007; 120(6), 1390–1401.CrossRefGoogle ScholarPubMed
Stergiotou, I, Crispi, F, Valenzuela-Alcaraz, B, Cruz-Lemini, M, Bijnens, B, Gratacos, E. Aortic and carotid intima–media thickness in term small-for-gestational-age newborns and relationship with prenatal signs of severity. Ultrasound Obstet Gynecol. 2014; 43(6), 625–631.CrossRefGoogle ScholarPubMed
Crispi, F, Bijnens, B, Figueras, F, et al. Fetal growth restriction results in remodeled and less efficient hearts in children. Circulation (New York, NY), 2010; 121(22), 2427–2436.Google ScholarPubMed
Burtchen, N, Myers, MM, Lucchini, M, Retamar, MO, Rodriguez, D, Fifer, WP. Autonomic signatures of late preterm, early term, and full term neonates during early postnatal life. Early Hum Dev. 2019; 137, 104817.CrossRefGoogle ScholarPubMed
Aye, CYL, Lewandowski, AJ, Oster, J, et al. Neonatal autonomic function after pregnancy complications and early cardiovascular development. Pediatr Res. 2018; 84(1), 85–91.CrossRefGoogle ScholarPubMed
Patural, H, Pichot, V, Jaziri, F, et al. Autonomic cardiac control of very preterm newborns: a prolonged dysfunction. Early Hum Dev. 2008; 84(10), 681–687.CrossRefGoogle ScholarPubMed
Karvonen, R, Sipola, M, Kiviniemi, A, et al. Cardiac autonomic function in adults born preterm. Journal Pediatr. 2019; 208, 96–103. e4.CrossRefGoogle ScholarPubMed
Karvonen, R, Sipola, M, Kiviniemi, AM, et al. Postexercise heart rate recovery in adults born preterm. J Pediatr. 2019; 214, 89–95.CrossRefGoogle ScholarPubMed
Massaro, AN, Govindan, RB, Al-Shargabi, T, et al. Heart rate variability in encephalopathic newborns during and after therapeutic hypothermia. J. Perinatol. 2014; 34(11), 836–841.CrossRefGoogle ScholarPubMed