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Histochemical localization and possible antibacterial role of xanthine oxidase in the bovine mammary gland

Published online by Cambridge University Press:  01 June 2009

Robert A. Collins ,
Keith R. Parsons ,
Terry R. Field  and
A. John Bramley
Robert A. Collins
Affiliation:
AFRC Institute for Animal Disease Research, Compton Laboratory, Compton, Newbury, RG16 0NN, UK
Keith R. Parsons
Affiliation:
AFRC Institute for Animal Disease Research, Compton Laboratory, Compton, Newbury, RG16 0NN, UK
Terry R. Field
Affiliation:
AFRC Institute for Animal Disease Research, Compton Laboratory, Compton, Newbury, RG16 0NN, UK
A. John Bramley
Affiliation:
AFRC Institute for Animal Disease Research, Compton Laboratory, Compton, Newbury, RG16 0NN, UK
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Summary

Xanthine oxidase (XO) was demonstrated to be present in the teat canal and secretory tissue of the bovine mammary gland by histochemical techniques. Homogenates of these tissues were able to replace XO in an antibacterial assay with Streptococcus uberis. The action of XO on its substrate hypoxanthine was shown to provide an essential component for anti-streptococcal activity mediated by lactoperoxidase. A mechanism is proposed whereby the interaction of XO, lactoperoxidase and thiocyanate may provide antibacterial activity in the teat canal.

Type
Original articles
Information
Journal of Dairy Research , Volume 55 , Issue 1 , February 1988 , pp. 25 - 32
Copyright
Copyright © Proprietors of Journal of Dairy Research 1988

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References

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