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The effects of pregnancy, lactation and involution on the metabolism of glucose by rat parametrial adipose tissue

Published online by Cambridge University Press:  01 June 2009

R. W. Smith
R. W. Smith
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading, RG2 9AT
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Summary

The incorporation of 14C from [1-14C] and [6-14C]glucose into CO2, fatty acids and glycerol by rat parametrial adipose tissue was measured at intervals during pregnancy, lactation and involution. There were small increases in the incorporation of both the C-1 and C-6 atoms into CO2 and glycerol on the seventh and sixteenth days of pregnancy. Fatty acid synthesis from glucose was negligible on the twentieth day of pregnancy and during lactation. Three days after weaning the rate of oxidation of the C-1 atom was doubled and the incorporation of both carbon atoms into fatty acids was increased at least 20-fold. There were no changes in the activities of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase during pregnancy and lactation, but 3 days after weaning the activities of both enzymes were doubled. These results are discussed in relation to other evidence that the total body fat is increased during pregnancy, and to the idea that the fat depots are mobilized during lactation.

Type
Research Article
Information
Journal of Dairy Research , Volume 40 , Issue 3 , October 1973 , pp. 353 - 360
Copyright
Copyright © Proprietors of Journal of Dairy Research 1973

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References

REFERENCES

Baldwin, R. L. (1970). Federation Proceedings 29, 1277.Google Scholar
Duncan, D. B. (1955). Biometrics 11, 1.CrossRefGoogle Scholar
Fain, J. N. & Scow, R. O. (1966). American Journal of Physiology 210, 19.CrossRefGoogle Scholar
Flatt, W. P. (1966). Journal of Dairy Science 49, 230.CrossRefGoogle Scholar
Folch, J., Lees, M. & Sloane-Stanley, G. H. (1957). Journal of Biological Chemistry 226, 497.CrossRefGoogle Scholar
Hamosh, M., Clary, T. R., Chernick, S. S. & Scow, R. O. (1970). Biochimica et Biophysica Acta 210, 473.CrossRefGoogle Scholar
Hytten, F. E. & Leitch, I. (1964). The Physiology of Human Pregnancy. Oxford: Blackwell Scientific Publications.Google Scholar
Knopp, R. H., Herrera, E. & Freinkel, N. (1970). Journal of Clinical Investigation 49, 1438.CrossRefGoogle Scholar
Moore, J. H. (1962). Journal of Dairy Research 29, 141.CrossRefGoogle Scholar
Otway, S. & Robinson, D. S. (1968). Biochemical Journal 106, 677.CrossRefGoogle Scholar
Smith, R. W. (1973). Journal of Dairy Research 40, 339.CrossRefGoogle Scholar
Smith, R. W. & Glascock, R. F. (1969). Journal of Dairy Research 36, 455.CrossRefGoogle Scholar
Winegrad, A. I. (1962). Vitamins and Hormones 20, 141.CrossRefGoogle Scholar