Skip to main content Accessibility help
×
Home
Hostname: page-component-99c86f546-8r8mm Total loading time: 0.423 Render date: 2021-12-02T17:00:19.446Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

Efficacy of enterotoxigenic Escherichia coli vaccine for bovine clinical mastitis

Published online by Cambridge University Press:  04 March 2011

Kazuhide Morimoto*
Affiliation:
Hiroshima Prefectural Technology Research Institute, Livestock Technology Research Center, 584 Nanatsuka-cho, Shobara, Hiroshima, 727-0023 Japan
Madoka Shimizu
Affiliation:
Hiroshima Prefectural West Livestock Health & Hygiene Service Center, 1-15, Saijogojo-cho, Higashihiroshima, Hiroshima 739-0013 Japan
Tomoyasu Kurose
Affiliation:
Higashihiroshima Veterinary Clinical Center, Hiroshima P.F.A.M.A.A 284-1, Inaki, Takaya-cho, Higashihiroshima, Hiroshima, 739-2106 Japan
Keiji Nakatani
Affiliation:
Hatsukaichi Veterinary Clinical Center, Hiroshima P.F.A.M.A.A 10-14, Honmachi, Hatsukaichi, Hiroshima, 738-0015 Japan
Shinji Akita
Affiliation:
Higashihiroshima Veterinary Clinical Center, Hiroshima P.F.A.M.A.A 284-1, Inaki, Takaya-cho, Higashihiroshima, Hiroshima, 739-2106 Japan
Yasunori Shinozuka
Affiliation:
Miyoshi Veterinary Clinical Center, Hiroshima P.F.A.M.A.A 3-6-36, Tokaichihigashi, Miyoshi, Hiroshima, 728-0013 Japan
Naoki Isobe
Affiliation:
Graduate School of Biosphere Science, Hiroshima University 1-4-4, Kagamiyama, Higashihiroshima, Hiroshima, 739-8528 Japan
*
*For correspondence: khd02062@nifty.com

Abstract

An enterotoxigenic Escherichia coli (ETEC) vaccine designed to prevent diarrhoea was inoculated into dairy cows, and the occurrence of clinical mastitis was investigated for 2 years. Half of 480 cows in five farms were subcutaneously inoculated with ETEC vaccine (Imocolibov) twice with a 1-month interval in 2007 and 2008. Fisher's exact test and survival (time to event) analysis with the log-rank test were used to compare vaccinates and controls. In 2007, there was no significant difference in the incidence rate of mastitis between vaccinate (20·3%) and control (17·1%) cows. The rate of death or culling due to mastitis was lower in vaccinated cows (7·4%) than in control cows (29·2%, P=0·07, Fisher's exact test; P=0·02, log-rank test). In 2008, there was no significant difference in both the incidence rate of mastitis and the rate of death or culling due to mastitis. Milk productivity was compared between vaccinates and controls in one farm. Multi-way analysis of variance (ANOVA) was performed for the amount of 4% fat-corrected milk, and there was no significant difference between vaccinates and controls. These results suggest that ETEC vaccine inoculation reduces death or culling due to mastitis, whereas no preventive effect on the development of mastitis was observed.

Type
Research Article
Copyright
Copyright © Proprietors of Journal of Dairy Research 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Burvenich, C, Merris, VV, Mehrzad, J, Diez-Fraile, A & Duchateau, L 2003 Severity of E. coli mastitis is mainly determined by cow factors. Veterinary Research 34 521564CrossRefGoogle ScholarPubMed
Dosogne, H, Vangroenweghe, F & Burvenich, C 2002 Potential mechanism of action of J5 vaccine in protection against severe bovine coliform mastitis. Veterinary Research 33 112CrossRefGoogle ScholarPubMed
González, RN, Cullor, JS, Jasper, DE, Farver, TB, Bushnell, RB & Oliver, MN 1989 Prevention of clinical coliform mastitis in dairy cows by mutant Escherichia coli vaccine. Canadian Journal of Veterinary Research 53 301305Google ScholarPubMed
Hogan, JS & Smith, KL 2003 Coliform mastitis. Veterinary Research 34 507519CrossRefGoogle ScholarPubMed
Hogan, JS, Smith, KL, Todhunter, DA & Schoenberger, PS 1992 Field trial to determine efficacy of an Escherichia coli J5 mastitis vaccine. Journal of Dairy Science 75 7884CrossRefGoogle ScholarPubMed
McClure, AM, Christopher, EE, Wolff, WA, Fales, WH, Krause, GF & Miramonti, J 1994 Effect of Re-17 Mutant Salmonella typhimurium bacterin toxoid on clinical coliform mastitis. Journal of Dairy Science 77 22722280CrossRefGoogle ScholarPubMed
Mizobuchi, S, Fujiaki, Y, Sasaki, H, Yamamoto, H, Zenba, S, Sakamoto, M & Kawada, C 1997 Trial of reducing death and disuse damages due to mastitis by means of inactivated vaccine of bovine toxigenic colibacillus. Journal of Veterinary Clinic 408 1316Google Scholar
Morimoto, K, Yoshimura, T, Osaka, T, Nagao, K, Shinde, S & Isobe, N 2009 Analysis of serological crossing between a bovine Escherichia coli inactivated vaccine for the prevention of diarrhea and an Escherichia coli J5 strain. Hiroshima Journal of Veterinary Medicine 24 5154Google Scholar
Overbeek, BP, Schellekens, JFP, Lippe, W, Dekker, BAT & Verhoef, J 1987 Carumonam enhances reactivity of Escherichia coli with mono- and polyclonal antisera to rough mutant Escherichia coli J5. Journal of Clinical Microbiology 25 10091013Google Scholar
Tyler, JW, Cullor, JS, Osburn, BI, Bushnell, RB & Fenwick, BW 1988 Relationship between serologic recognition of Escherichia coli O111:B4 (J5) and clinical coliform mastitis in cattle. American Journal of Veterinary Research 49 19501954Google Scholar
Tyler, JW, Spears, H & Nelson, R 1992 Antigenic homology of endotoxin with a coliform mastitis vaccine strain, Escherichia coli O111:B4 (J5). Journal of Dairy Science 75 18211825CrossRefGoogle Scholar
Wilson, DJ, Grohn, YT, Bennett, GJ, González, RN, Schukken, YH & Spatz, J 2007 Comparison of J5 vaccinates and controls for incidence, etiologic agent, clinical severity and survival in the herd following naturally occurring cases of clinical mastitis. Journal of Dairy Science 90 42824288CrossRefGoogle ScholarPubMed
2
Cited by

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Efficacy of enterotoxigenic Escherichia coli vaccine for bovine clinical mastitis
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Efficacy of enterotoxigenic Escherichia coli vaccine for bovine clinical mastitis
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Efficacy of enterotoxigenic Escherichia coli vaccine for bovine clinical mastitis
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *