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Dissemination of staphylococci in mice with experimental mastitis

Published online by Cambridge University Press:  01 June 2009

James C. Anderson
Affiliation:
AFRC Institute for Animal Diseases Research, Compton Laboratory, Newbury RG16 0NN, UK

Summary

During the course of an acute, fatal mastitis in mice caused by intra-mammary injection of ∼ 105 cfu of Staphylococcus aureus, small numbers of staphylococci were detected in liver, spleen, kidney and heart. Transport from the mammary gland was by the venous blood system with no evidence of lymph node involvement. Intravenous injection of 100 times more staphylococci (∼107 cfu) than were fatal by the intramammary route failed to kill the mice and small numbers of staphylococci were found in the visceral organs. However, intravenous injection of ∼ 108 cfu of Staph. aureus was fatal and large numbers of staphylococci were found in the visceral organs. Treatment with cloxacillin (500 μg) by the intramammary or subcutaneous routes, or equally divided between these two routes, cleared the visceral organs of staphylococci; subcutaneous therapy had a limited and variable effect on numbers of staphylococci in the mammary gland while intramammary and divided treatments significantly reduced the numbers of staphylococci. Thus, staphylococci are disseminated to visceral organs during acute staphylococcal mastitis, but this makes a negligible contribution to the clinical disease.

Type
Original Articles
Copyright
Copyright © Proprietors of Journal of Dairy Research 1987

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References

Anderson, J. C. 1976 The contribution of the mouse mastitis model to our understanding of staphylococcal infection. In Staphylococci and Staphylococcal Diseases (International Symposium 3, 1975) pp. 783790 (Ed. Jeljaszewicz, J.) Stuttgart: Gustav Fischer Verlag (Zentralblatt für Bakteriologie, Parasitenkunde, Infektions-krankheiten und Hygiene, 1. Abteilung, Supplement 5)Google Scholar
Anderson, J. C. 1978 The effect of colonization of the mouse mammary gland by Staphylococcus epidermidis on subsequent infection with Staphylococcus aureus or Escherichia coli. Journal of Comparative Pathology 88 545553CrossRefGoogle ScholarPubMed
Anderson, J. C. 1981 The behaviour of a capsulate strain of Staphylococcus aureus in the mammary gland of the mouse. In Staphylococci and Staphylococcus Infections (International Symposium 4,1979) pp. 667672 (Ed. Jeljaszewicz, J.) Stuttgart: Gustav Fischer Verlag (Zentralblatt für Balcteriologie, Mikrobiologie und Hygiene, 1. Abteilung, Supplement 10)Google Scholar
Anderson, J. C. 1983 Veterinary aspects of staphylococci. In Staphylococci and Staphylococcal Infections vol. 1 pp. 193241 (Ed. Easmon, C. S. F. and Adlam, C.) London: Academic PressGoogle Scholar
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MacDiarmid, S. C. 1978 Antibacterial drugs used against mastitis in cattle by the systemic route. New Zealand Veterinary Journal 26 290295CrossRefGoogle ScholarPubMed
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