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2302 Impacts of postnatal nest change on early development

Published online by Cambridge University Press:  21 November 2018

Antonia P. Francis ,
Anna Kuznetsova ,
Keith Martinez II  and
Maria Gloria Dominguez-Bello
Antonia P. Francis
Affiliation:
H+H Clinical and Translational Science Institute, NYU
Anna Kuznetsova
Affiliation:
H+H Clinical and Translational Science Institute, NYU New York University Undergraduate, New York, NY, USA
Keith Martinez II
Affiliation:
H+H Clinical and Translational Science Institute, NYU Department of Medicine, New York University Langone Medical Center, New York, NY, USA Department of Microbiology, New York University Langone Medical Center, New York, NY, USA Sackler Institute, New York University School of Medicine, New York, NY, USA
Maria Gloria Dominguez-Bello
Affiliation:
H+H Clinical and Translational Science Institute, NYU Department of Medicine, New York University Langone Medical Center, New York, NY, USA Department of Biochemistry and Microbiology, and of Anthropology, Rutgers University, NJ, USA
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Abstract

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OBJECTIVES/SPECIFIC AIMS: It has been reported that birth mode affects development, with cesarean section born mice gaining more body weight during development. Since mice C-sections involve fostering and nest change, we sought to determine whether changing only the nest and cage would have an effect on development. METHODS/STUDY POPULATION: A total of 53 mice were born to 9 dams, and 21 babies (4 litters) were exchanged in pairs to foreign cages and nests. Litters were followed for body weight and mothers were observed during periods for maternal and nonmaternal behaviors. RESULTS/ANTICIPATED RESULTS: The results show that average body weight was significantly higher in the experimental group in both genders, with 20% higher body weights at weaning. The mothers from the litters that were changed to a new nest showed significantly more non-maternal behavior in the first 2 days if life, than the controls. DISCUSSION/SIGNIFICANCE OF IMPACT: The results suggest that changes in maternal behavior may be linked to the increased weight gain in their babies.

Type
Basic/Translational Science/Team Science
Information
Journal of Clinical and Translational Science , Volume 2 , Supplement S1 , June 2018 , pp. 15
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Association for Clinical and Translational Science 2018