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Clozapine induced myocarditis: a case report and literature review

Published online by Cambridge University Press:  13 June 2014

Sunday O Okereke
Affiliation:
Department of Psychiatry, Adelaide and Meath Hospital including the National Children's Hospital, Tallaght, Dublin 24, Ireland
Wan MY Mohd Abdoh
Affiliation:
Department of Psychiatry, Adelaide and Meath Hospital including the National Children's Hospital, Tallaght, Dublin 24, Ireland
Bernadette M Murphy
Affiliation:
Department of Psychiatry, Adelaide and Meath Hospital including the National Children's Hospital, Tallaght, Dublin 24, Ireland
Corresponding

Abstract

Clozapine, the drug of choice for treatment resistant schizophrenia, has a range of serious cardiac side-effects. This paper describes a fatal case of myocarditis in a 48 year old man four weeks after starting clozapine. In particular, this case illustrates how incipient the disorder can be and the need for a high level of suspicion. Difficulties in diagnosing clozapine induced myocarditis and ways to minimise its risk are also discussed.

Type
Case Reports
Copyright
Copyright © Cambridge University Press 2009

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References

1.Clozapine, SPC (Date of revision November 2005). Electronic Medicines Compendium (eMC). http://emc.medicines.org.uk (accessed 12 December 2008).Google Scholar
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4.Hass, SJ, Hill, R, Krum, H, Liew, D, Tonkin, A, Demos, L, et al.Clozapine-associated myocarditis: A review of 116 Cases of Suspected Myocarditis Associated with the use of Clozapine in Australia during 1993-2003. Drug Saf 2007; 30 (1): 4757.CrossRefGoogle Scholar
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7.Pieroni, M, Cavallaro, R, Chimenti, C, Smeraldi, E, Frustaci, A. Clozapine-induced hypersensitivity myocarditis. Chest 2004; 126: 1703–5.CrossRefGoogle ScholarPubMed

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