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Molecular imaging biomarkers for dementia with Lewy bodies: an update

Published online by Cambridge University Press:  22 December 2014

Elizabeta B. Mukaetova-Ladinska
Elizabeta B. Mukaetova-Ladinska*
Affiliation:
Newcastle University, Newcastle upon Tyne, UK
*
Correspondence should be addressed to: E. B. Mukaetova-Ladinska, Institute of Neuroscience and Newcastle University Institute for Ageing Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK. Phone: +44 191 246 8777/+44 191 282 0045; Fax: +44 191 282 4839. Email: Elizabeta.Mukaetova-Ladinska@ncl.ac.uk.
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Abstract

Background:

Dementia with Lewy body (DLB) is considered to be the second most common form of neurodegenerative disorders after Alzheimer's disease (AD), affecting as many as 100,000 people in the UK and up to 1.3 million in the USA. However, nearly half of patients with DLB remain undiagnosed thus depriving many of them from an early and adequate treatment of their distressing symptoms. Accurate and early diagnosis of DLB is important for both patients and their caregivers, since the neuropsychiatric symptoms require specific management.

Methods:

In the current study, we review the most recent developments in the field of molecular nuclear imaging to diagnose DLB.

Results:

The review addresses, the neurotransmitter based (dopaminergic, cholinergic, and glutamatergic) nuclear imaging techniques, role of the autonomic dysfunction and its visualization in DLB with myocardial sympathetic imaging and vesicular catecholamine uptake, as well as the use of amyloid polypeptides and glial markers as molecular imaging probes in the clinical diagnosis of DLB.

Conclusions:

Most of the above nuclear imaging methods are restricted to highly specialized clinical centers, and thus not applicable to a large number of patients requiring dementia (e.g. DLB) diagnosis in routine clinical setting. Validating them against more readily accessible peripheral biomarkers, e.g. CSF and blood biomarkers linked to the DLB process, may facilitate their use in wider clinical settings.

Keywords

dementia with Lewy bodyimagingneurotransmitterdopamineacetylcholineglutamatemyocardial sympathetic imagingvesicular catecholamineamyloid peptidesamyloid-betagliaα-synuclein
Type
Review Article
Information
International Psychogeriatrics , Volume 27 , Issue 4 , April 2015 , pp. 555 - 577
Copyright
Copyright © International Psychogeriatric Association 2014 

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