Dr. Grossberg began the discussion by sharing preliminary data from a study designed to determine risk factors for institutionalization in patients with autopsy-confirmed Alzheimer's disease (AD). Initial findings from this study, which enrolled 100 patients, indicate that the principal predictor of institutionalization is behavioral and psychological symptoms of dementia (BPSD), principally agitation, aggressiveness, and problem wandering. Difficulty with activities of daily living, especially related to continence and hygiene issues, was the second most common predictor of institutionalization. The third most common predictor was lack of a caregiver, either because of death or because of other reasons.