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γ-Aminobutyric acid type A receptor binding affinity in the right inferior frontal gyrus at resting state predicts the performance of healthy elderly people in the visual sustained attention test

Published online by Cambridge University Press:  21 March 2018

Masato Kasagi Open the ORCID record for Masato Kasagi [Opens in a new window] ,
Tomokazu Motegi ,
Kosuke Narita ,
Kazuyuki Fujihara ,
Yusuke Suzuki ,
Minami Tagawa ,
Koichi Ujita ,
Hirotaka Shimada  and
Masato Fukuda
Masato Kasagi
Affiliation:
Department of Psychiatry and Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
Tomokazu Motegi
Affiliation:
Department of Psychiatry and Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
Kosuke Narita*
Affiliation:
Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
Kazuyuki Fujihara
Affiliation:
Department of Psychiatry and Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
Yusuke Suzuki
Affiliation:
Department of Psychiatry and Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
Minami Tagawa
Affiliation:
Department of Psychiatry and Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
Koichi Ujita
Affiliation:
Department of Radiology, Gunma University Hospital, Maebashi, Gunma, Japan
Hirotaka Shimada
Affiliation:
Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
Masato Fukuda
Affiliation:
Department of Psychiatry and Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
*
Correspondence should be addressed to: Kosuke Narita, Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario K1Z 7K4, Canada. Phone: +1-613-722-6521 ext. 6870; Fax: +1-613-798-2982. Email: Kosuke.Narita@theroyal.ca
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Abstract

Background:

Although recent studies have suggested that the γ-aminobutyric acid type A (GABAA) receptor binding affinity can be a more sensitive marker of age-related neuronal loss than regional gray matter (GM) volume, knowledge about the relationship between decreased GABAA receptor binding affinity and cognitive decline during normal aging is still limited.

Methods:

Thirty-seven healthy elderly individuals (aged 50–77 years (mean, 64.5 ± 7.3 years); 15 males and 22 females) were enrolled in this study. We investigated the association of the performance of the healthy elderly in the attentional function test with regional GM volume, regional cerebral bold flow (rCBF), and GABAA receptor binding affinity in the resting state by structural magnetic resonance imaging (MRI), arterial spin labeling (ASL), and 123I-iomazenil (IMZ) SPECT, with the analysis focusing on the bilateral inferior frontal gyri.

Results:

The score of the rapid visual information processing (RVP) test, which is used to assess visual sustained attention, showed a positive correlation with GABAA receptor binding affinity in the right inferior frontal gyrus. No significant correlation was found between RVP test score and regional GM volume or rCBF.

Conclusion:

The findings of 123I-IMZ SPECT, but not those of structural MRI or ASL, suggest that a decreased GABAA receptor binding affinity can be a sensitive marker of cognitive impairment.

Keywords

right inferior frontal gyrusattentional function123I-iomazenil SPECTstructural MRIarterial spin labelinghealthy elderly
Type
Original Research Article
Information
International Psychogeriatrics , Volume 30 , Issue 9: Issue Theme: Quality of Care for Frail Older Adults , September 2018 , pp. 1385 - 1391
Copyright
Copyright © International Psychogeriatric Association 2018 

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