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Subjective memory complaints predict baseline but not future cognitive function over three years: results from the Western Australia Memory Study

Published online by Cambridge University Press:  02 October 2018

Hamid R. Sohrabi*
Affiliation:
Centre of Excellence for Alzheimer’s disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia Department of Biomedical Sciences, Macquarie University, Port Macquarie, New South Wales, Australia The School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Western Australia, Australia
Michael Weinborn
Affiliation:
Centre of Excellence for Alzheimer’s disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia
Christoph Laske
Affiliation:
Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tuebingen, Tübingen, Germany German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Tübingen, Germany
Kristyn A. Bates
Affiliation:
School of Animal Biology, University of Western Australia, Crawley, Western Australia, Australia
Daniel Christensen
Affiliation:
Telethon Kids Institute, Subiaco, Western Australia, Australia
Kevin Taddei
Affiliation:
Centre of Excellence for Alzheimer’s disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia The School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Western Australia, Australia
Stephanie R. Rainey-Smith
Affiliation:
Centre of Excellence for Alzheimer’s disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Belinda M. Brown
Affiliation:
Centre of Excellence for Alzheimer’s disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Samantha L. Gardener
Affiliation:
Centre of Excellence for Alzheimer’s disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Simon M. Laws
Affiliation:
Centre of Excellence for Alzheimer’s disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Georgia Martins
Affiliation:
Centre of Excellence for Alzheimer’s disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Samantha C. Burnham
Affiliation:
CSIRO Floreat, Floreat, Western Australia, Australia
Romola S. Bucks
Affiliation:
School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia
Barry Reisberg
Affiliation:
New York University Langone Medical Center, New York, NY, USA
Nicola T. Lautenschlager
Affiliation:
The School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Western Australia, Australia Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia NorthWestern Mental Health, Melbourne Health, Melbourne, Victoria, Australia
Jonathan Foster
Affiliation:
School of Psychology and Speech Pathology, Curtin University, Bentley, Western Australia, Australia Neurosciences Unit, North Metropolitan Health Service, Health Department of Western Australia, Mount Claremont, Western Australia, Australia Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Crawley, Western Australia, Australia
Ralph N. Martins
Affiliation:
Centre of Excellence for Alzheimer’s disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia Department of Biomedical Sciences, Macquarie University, Port Macquarie, New South Wales, Australia The School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Western Australia, Australia
*
Correspondence should be addressed to: Hamid Sohrabi, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Dr., Joondalup, WA 6027, Australia. Phone: +61 08 6457 0266; Fax: +61 08 6457 0270. Email: h.sohrabi@ecu.edu.au.

Abstract

Background:

This study investigated the characteristics of subjective memory complaints (SMCs) and their association with current and future cognitive functions.

Methods:

A cohort of 209 community-dwelling individuals without dementia aged 47–90 years old was recruited for this 3-year study. Participants underwent neuropsychological and clinical assessments annually. Participants were divided into SMCs and non-memory complainers (NMCs) using a single question at baseline and a memory complaints questionnaire following baseline, to evaluate differential patterns of complaints. In addition, comprehensive assessment of memory complaints was undertaken to evaluate whether severity and consistency of complaints differentially predicted cognitive function.

Results:

SMC and NMC individuals were significantly different on various features of SMCs. Greater overall severity (but not consistency) of complaints was significantly associated with current and future cognitive functioning.

Conclusions:

SMC individuals present distinctive features of memory complaints as compared to NMCs. Further, the severity of complaints was a significant predictor of future cognition. However, SMC did not significantly predict change over time in this sample. These findings warrant further research into the specific features of SMCs that may portend subsequent neuropathological and cognitive changes when screening individuals at increased future risk of dementia.

Type
Original Research Article
Copyright
© International Psychogeriatric Association 2018 

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References

Abdulrab, K. and Heun, R. (2008). Subjective memory impairment. A review of its definitions indicates the need for a comprehensive set of standardised and validated criteria. European Psychiatry, 23, 321330. doi: 10.1016/j.eurpsy.2008.02.004.CrossRefGoogle ScholarPubMed
Adams, K. B., Matto, H. C. and Sanders, S. (2004). Confirmatory factor analysis of the Geriatric Depression Scale. Gerontologist, 44, 818826. doi: 10.1093/geront/44.6.818.CrossRefGoogle ScholarPubMed
Barker, A., Prior, J. and Jones, R. (1995). Memory complaint in attenders at a self-referral memory clinic: the role of cognitive-factors, affective symptoms and personality. International Journal of Geriatric Psychiatry, 10, 777781. doi: 10.1002/gps.930100908.CrossRefGoogle Scholar
Beardsall, L. (1998). Development of the Cambridge Contextual Reading Test for improving the estimation of premorbid verbal intelligence in older persons with dementia. British Journal of Clinical Psychology, 37, 229240. doi: 10.1111/j.2044-8260.1998.tb01297.x.CrossRefGoogle ScholarPubMed
Cherbuin, N., Kim, S. and Anstey, K. J. (2015). Dementia risk estimates associated with measures of depression: a systematic review and meta-analysis. BMJ Open, 5, e008853. doi: 10.1136/bmjopen-2015-008853.CrossRefGoogle ScholarPubMed
Crumley, J. J., Stetler, C. A. and Horhota, M. (2014). Examining the relationship between subjective and objective memory performance in older adults: a meta-analysis. Psychology and Aging, 29, 250263. doi: 10.1037/a0035908.CrossRefGoogle ScholarPubMed
Derouesne, C., Lacomblez, L., Thibault, S. and Leponcin, M. (1999). Memory complaints in young and elderly subjects. International Journal of Geriatric Psychiatry, 14, 291301. doi: 10.1002/(SICI)1099-1166(199904)14:4<291::AID-GPS902>3.0.CO;2-7.3.0.CO;2-7>CrossRefGoogle Scholar
Gilewski, M. J., Zelinski, E. M. and Schaie, K. W. (1990). The memory functioning questionnaire for assessment of memory complaints in adulthood and old age. Psychology and Aging, 5, 482490. doi: 10.1037/0882-7974.5.4.482.CrossRefGoogle ScholarPubMed
Gino, S. et al. (2010). Memory complaints are frequent but qualitatively different in young and elderly healthy people. Gerontology, 56, 272277. doi: 10.1159/000240048.CrossRefGoogle Scholar
Hanzevacki, M., Ozegovic, G., Simovic, I. and Bajic, Z. (2011). Proactive approach in detecting elderly subjects with cognitive decline in general practitioners’ practices. Dementia and Geriatric Cognitive Disorders Extra, 1, 93102. doi: 10.1159/000327076.CrossRefGoogle ScholarPubMed
Herrmann, D., Sheets, V., Gruneberg, M. and Torres, R. (2005). Are self reports of memory failure accurate? Applied Cognitive Psychology, 19, 821841. doi: 10.1002/acp.1125.CrossRefGoogle Scholar
Hixson, J. E. and Vernier, D. T. (1990). Restriction of human apolipoprotein E by gene amplification and cleavage with HhaI. Journal of Lipid Research, 31, 545548.Google ScholarPubMed
Howieson, D. B., Mattek, N., Dodge, H. H., Erten-Lyons, D., Zitzelberger, T. and Kaye, J. A. (2015). Memory complaints in older adults: prognostic value and stability in reporting over time. SAGE Open Medicine, 3, 205031211557479. doi: 10.1177/2050312115574796.CrossRefGoogle ScholarPubMed
Jessen, F. et al. (2010). Prediction of dementia by subjective memory impairment effects of severity and temporal association with cognitive impairment. Archives of General Psychiatry, 67, 414422. doi: 10.1001/archgenpsychiatry.2010.30.CrossRefGoogle ScholarPubMed
Jessen, F. et al. (2014). A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease. Alzheimer’s & Dementia, 10, 844852. doi: 10.1016/j.jalz.2014.01.001.CrossRefGoogle ScholarPubMed
Johansson, L. et al. (2014). Midlife personality and risk of Alzheimer disease and distress: a 38-year follow-up. Neurology, 83, 15381544. doi: 10.1212/WNL.0000000000000907.CrossRefGoogle ScholarPubMed
Johnson, L. A. et al. (2015). A depressive endophenotype of poorer cognition among cognitively healthy community-dwelling adults: results from the Western Australia memory study. International Journal of Geriatric Psychiatry, 30, 881886. doi: 10.1002/gps.4231.CrossRefGoogle ScholarPubMed
Koppara, A. et al. (2015). Cognitive performance before and after the onset of subjective cognitive decline in old age. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 1, 194205.Google ScholarPubMed
Krell-Roesch, J. et al. (2015). APOE epsilon4 genotype and the risk for subjective cognitive impairment in elderly persons. The Journal of Neuropsychiatry and Clinical Neurosciences, 27, 322325. doi: 10.1176/appi.neuropsych.14100268.CrossRefGoogle ScholarPubMed
Kryscio, R. J. et al. (2014). Self-reported memory complaints: implications from a longitudinal cohort with autopsies. Neurology, 83, 13591365. doi: 10.1212/WNL.0000000000000856.CrossRefGoogle ScholarPubMed
Lane, C. J. and Zelinski, E. M. (2003). Longitudinal hierarchical linear models of the memory functioning questionnaire. Psychology and Aging, 18, 3853. doi: 10.1037/0882-7974.18.1.38.CrossRefGoogle ScholarPubMed
Langlois, A. S. and Belleville, S. (2014). Subjective cognitive complaint in healthy older adults: identification of major domains and relation to objective performance. Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition, 21, 257282. doi: 10.1080/13825585.2013.795928.CrossRefGoogle ScholarPubMed
Laske, C. et al. (2015a). Innovative diagnostic tools for early detection of Alzheimer’s disease. Alzheimer’s & Dementia, 11, 561578. doi: 10.1016/j.jalz.2014.06.004.CrossRefGoogle ScholarPubMed
Laske, C. et al. (2015b). Diagnostic value of subjective memory complaints assessed with a single item in dominantly inherited Alzheimer’s disease: results of the DIAN study. BioMed Research International, 2015, 17. doi: 10.1155/2015/828120.CrossRefGoogle ScholarPubMed
Lovelace, E. A. and Twohig, P. T. (1990). Healthy older adults’ perceptions of their memory functioning and use of mnemonics. Bulletin of the Psychonomic Society, 28, 115118. doi: 10.3758/BF03333979.CrossRefGoogle Scholar
Mattos, P., Lino, V., Rizo, L., Alfano, A., Araujo, C. and Raggio, R. (2003). Memory complaints and test performance in healthy elderly persons. Arquivos de Neuro-Psiquiatria, 61, 920924. doi: 10.1590/S0004-282X2003000600006.CrossRefGoogle ScholarPubMed
Merema, M. R., Speelman, C. P., Foster, J. K. and Kaczmarek, E. A. (2013). Neuroticism (not depressive symptoms) predicts memory complaints in some community-dwelling older adults. The American Journal of Geriatric Psychiatry, 21, 729736. doi: 10.1016/j.jagp.2013.01.059.CrossRefGoogle ScholarPubMed
Merrill, D. A. et al. (2012). Self-reported memory impairment and brain PET of amyloid and tau in middle-aged and older adults without dementia. International Psychogeriatrics, 24, 10761084. doi: 10.1017/S1041610212000051.CrossRefGoogle ScholarPubMed
Mitchell, A. J. (2008). The clinical significance of subjective memory complaints in the diagnosis of mild cognitive impairment and dementia: a meta-analysis. International Journal of Geriatric Psychiatry, 23, 11911202. doi: 10.1002/gps.2053.CrossRefGoogle Scholar
Mitchell, A. J., Beaumont, H., Ferguson, D., Yadegarfar, M. and Stubbs, B. (2014). Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis. Acta Psychiatrica Scandinavica, 130, 439451. doi: 10.1111/acps.12336.CrossRefGoogle ScholarPubMed
Mol, M. E., Van Boxtel, M. P., Willems, D. and Jolles, J. (2006). Do subjective memory complaints predict cognitive dysfunction over time? A six-year follow-up of the Maastricht aging study. International Journal of Geriatric Psychiatry, 21, 432441. doi: 10.1002/gps.1487.CrossRefGoogle ScholarPubMed
Montejo, P., Montenegro, M., Fernandez, M. A. and Maestu, F. (2011). Subjective memory complaints in the elderly: prevalence and influence of temporal orientation, depression and quality of life in a population-based study in the city of Madrid. Aging and Mental Health, 15, 8596. doi: 10.1080/13607863.2010.501062.CrossRefGoogle Scholar
Perrotin, A. et al. (2017). Subjective cognitive decline in cognitively normal elders from the community or from a memory clinic: differential affective and imaging correlates. Alzheimer’s & Dementia, 13, 550560. doi: 10.1016/j.jalz.2016.08.011.CrossRefGoogle ScholarPubMed
Reisberg, B., Shulman, M. B., Torossian, C., Leng, L. and Zhu, W. (2010). Outcome over seven years of healthy adults with and without subjective cognitive impairment. Alzheimer’s & Dementia, 6, 1124. doi: 10.1016/j.jalz.2009.10.002.CrossRefGoogle ScholarPubMed
Revell, A. J., Caskie, G. I. L., Willis, S. L. and Schaie, K. W. (2001). Replication and exploration of factor solutions for the memory functioning questionnaire (MFQ) in older adults. Gerontologist, 41, 133137. doi: 10.1093/geront/41.1.133.Google Scholar
Risacher, S. L. et al. (2015). APOE effect on Alzheimer’s disease biomarkers in older adults with significant memory concern. Alzheimer’s & Dementia, 11, 14171429. doi: 10.1016/j.jalz.2015.03.003.CrossRefGoogle ScholarPubMed
Roehr, S., Villringer, A., Angermeyer, M. C., Luck, T. and Riedel-Heller, S. G. (2016). Outcomes of stable and unstable patterns of subjective cognitive decline: results from the Leipzig Longitudinal Study of the Aged (LEILA75+). BMC Geriatrics, 16, 180. doi: 10.1186/s12877-016-0353-8.CrossRefGoogle Scholar
Ronnlund, M., Sundstrom, A., Adolfsson, R. and Nilsson, L. G. (2015). Subjective memory impairment in older adults predicts future dementia independent of baseline memory performance: evidence from the Betula prospective cohort study. Alzheimer’s & Dementia, 11, 13851392. doi: 10.1016/j.jalz.2014.11.006.CrossRefGoogle ScholarPubMed
Roth, M., Huppert, F. A., Mountjoy, C. Q. and Tym, E. (1998). CAMDEX-R. Cambridge: Cambridge University Press.Google Scholar
Salem, L. C., Vogel, A., Ebstrup, J., Linneberg, A. and Waldemar, G. (2015). Subjective cognitive complaints included in diagnostic evaluation of dementia helps accurate diagnosis in a mixed memory clinic cohort. International Journal of Geriatric Psychiatry, 30, 11771185. doi: 10.1002/gps.4272.CrossRefGoogle Scholar
Sas Institute Inc. (20022012). SAS for Windows Version 9.4. Cary, NC: SAS Institute Inc.Google Scholar
Saunders, A. M. et al. (1993). Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer’s disease. Neurology, 43, 14671472. doi: 10.1212/WNL.43.8.1467.CrossRefGoogle ScholarPubMed
Silva, D., Guerreiro, M., Faria, C., Maroco, J., Schmand, B. A. and De Mendonca, A. (2014). Significance of subjective memory complaints in the clinical setting. Journal of Geriatric Psychiatry and Neurology, 27, 259265. doi: 10.1177/0891988714532018.CrossRefGoogle ScholarPubMed
Singer, J. D. and Willett, J. B. (2003). Applied Longitudinal Data Analysis: Modeling Change and Event Occurrence. New York: Oxford University Press.CrossRefGoogle Scholar
Small, G. W. et al. (2001). Memory self-appraisal and depressive symptoms in people at genetic risk for Alzheimer’s disease. International Journal of Geriatric Psychiatry, 16, 10711077. doi: 10.1002/gps.481.CrossRefGoogle ScholarPubMed
Snitz, B. E. et al. (2015). Subjective cognitive complaints, personality and brain amyloid-beta in cognitively normal older adults. American Journal of Geriatric Psychiatry, 23, 985993. doi: 10.1016/j.jagp.2015.01.008.CrossRefGoogle ScholarPubMed
Sohrabi, H. R. et al. (2009). The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein E epsilon4 carriers and non-carriers. Journal of Alzheimer’s Disease, 17, 6979. doi: 10.3233/JAD-2009-1018.CrossRefGoogle ScholarPubMed
Wenham, P. R., Price, W. H. and Blandell, G. (1991). Apolipoprotein E genotyping by one-stage PCR. Lancet, 337, 11581159. doi: 10.1016/0140-6736(91)92823-K.CrossRefGoogle ScholarPubMed
Wicklin, R. 2015. How to winsorize data in SAS. The DO Loop [Online]. Available at: https://blogs.sas.com/content/iml/2015/07/15/winsorize-data.html, 2018.Google Scholar
Wolfsgruber, S. et al. (2016). Differential risk of incident Alzheimer’s disease dementia in stable versus unstable patterns of subjective cognitive decline. Journal of Alzheimer’s Disease, 54, 11351146. doi: 10.3233/JAD-160407.CrossRefGoogle ScholarPubMed
Yesavage, J. A. et al. (1983). Development and validation of a geriatric depression screening scale: a preliminary report. Journal of Psychiatric Research, 17, 3749. doi: 10.1016/0022-3956(82)90033-4.CrossRefGoogle Scholar
Zelinski, E. M., Gilewski, M. J. and Anthony-Bergstone, C. R. (1990). Memory functioning questionnaire: concurrent validity with memory performance and self-reported memory failures. Psychology and Aging, 5, 388399. doi: 10.1037/0882-7974.5.3.388.CrossRefGoogle ScholarPubMed
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Subjective memory complaints predict baseline but not future cognitive function over three years: results from the Western Australia Memory Study
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