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Butyrylcholinesterase and Cognitive Function

Published online by Cambridge University Press:  10 January 2005

Sultan Darvesh
Affiliation:
Department of Medicine, Divisions of Neurology, Dalhousie University, Halifax, Nova Scotia, Canada Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Chris MacKnight
Affiliation:
Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Kenneth Rockwood
Affiliation:
Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

Abstract

Butyrylcholinesterase (BuChE) is expressed in brain structures involved in cognition, but the effect of selective BuChE inhibitors on human cognitive function is unknown. We report a patient whose cognitive function deteriorated following a reduction and improved following reinstitution of ethopropazine, a selective BuChE inhibitor. We suggest that, because neurons expressing BuChE may be involved in cognition, there is merit to further evaluation of selective BuChE inhibitors in treating cognitive dysfunction.

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Copyright
© 2001 International Psychogeriatric Association

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