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Altered neurochemical metabolites in Alzheimer's disease patients with unawareness of deficits

Published online by Cambridge University Press:  28 November 2013

Yi-Chun Yeh
Affiliation:
Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Cheng-Fang Yen*
Affiliation:
Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Chun-Wei Li
Affiliation:
Department of Medical Imaging and Radiological Sciences, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
Yu-Ting Kuo
Affiliation:
Department of Medical Imaging and Radiological Sciences, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Department of Medical Imaging, Chi Mei Medical Center, Tainan, Taiwan Department of Radiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Chia-Hui Chen
Affiliation:
College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Chen-Chang Lee
Affiliation:
Department of Radiology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Taiwan
Gin-Chung Liu
Affiliation:
Department of Medical Imaging and Radiological Sciences, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Department of Radiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Mei-Feng Huang
Affiliation:
Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Tai-Ling Liu
Affiliation:
Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Cheng-Sheng Chen*
Affiliation:
Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
*
Correspondence should be addressed to: Cheng-Sheng Chen and Cheng-Feng Yen, Department of Psychiatry, Kaohsiung Medical University Hospital, #100, Tzyou 1st Rd, Kaohsiung City, Taiwan 807. Phone: +886-7-312-1101, ext. 6816; Fax: +886-7-3134761. Email: sheng@kmu.edu.tw or chfaye@kmu.edu.tw.
Correspondence should be addressed to: Cheng-Sheng Chen and Cheng-Feng Yen, Department of Psychiatry, Kaohsiung Medical University Hospital, #100, Tzyou 1st Rd, Kaohsiung City, Taiwan 807. Phone: +886-7-312-1101, ext. 6816; Fax: +886-7-3134761. Email: sheng@kmu.edu.tw or chfaye@kmu.edu.tw.

Abstract

Background:

Unawareness of deficits is common and is associated with poor outcomes in Alzheimer's disease (AD); however, little is known about correlated neurobiochemical changes.

Methods:

Proton magnetic resonance spectroscopy was used to examine neurobiochemical correlates of unawareness of deficits as assessed by the Dementia Deficit Scale in 36 patients with AD. Magnetic resonance spectroscopy spectra were acquired from the anterior cingulate area and right orbitofrontal area. Concentrations of N-acetyl-aspartate (NAA), total creatine, and other neurometabolites were calculated.

Results:

Nineteen (52.8%) participants had relative unawareness of deficits. This condition was negatively correlated with NAA/creatine in the anterior cingulate area (β = −0.36, p = 0.025) and positively correlated with NAA/creatine in the right orbitofrontal area (β = 0.41, p = 0.009) after controlling for dementia severity.

Conclusions:

These findings suggest unawareness of deficits in AD was associated with the altered neurochemical metabolites in the anterior cingulate area and right orbitofrontal area. However, the two areas might have opposite neuronal functions in unawareness of deficits.

Type
Research Article
Copyright
Copyright © International Psychogeriatric Association 2013 

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