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Neuronal Replacement After Traumatic or Age-Dependent Brain Damage

A Review of Experimental Work in Rodents and its Clinical Implications

Published online by Cambridge University Press:  10 March 2009

Anders Björklund  and
Fred H. Gage
Anders Björklund
Affiliation:
Department of HistologyUniversity of Lund
Fred H. Gage
Affiliation:
Department of HistologyUniversity of Lund
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Extract

During the last few years evidence has accumulated that fetal neurons, implanted into the depth of the brain in adult rats, can reestablish damaged connections in the host brain and substitute functionally for elements lost or damaged as a result of a preceding lesion. This research work has led to the realization that, contrary to traditional views, the adult mammalian CNS has a potential to incorporate new neuronal elements into already established neuronal circuitry and that such implanted neurons can modify the function and behavior of the recipient. For a long time it was thought that the remarkable regenerative and functional potential of CNS tissue grafts that had been demonstrated in cold-blooded vertebrates reflected a fundamental difference in the regenerative properties of central nervous tissue between cold-blooded vertebrates and mammals. During the last few years it has become evident however, that at least certain types of intracerebral neural grafts can perfoum just as well in developing and mammals as in developing or adult submammalian vertebrates.

Type
Technology and Health Care for the Elderly
Information
International Journal of Technology Assessment in Health Care , Volume 1 , Issue 1 , January 1985 , pp. 93 - 107
Copyright
Copyright © Cambridge University Press 1985

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