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Establishment and implementation of hospital-based health technology assessment at King Hussein Cancer Center: can our model be an example?

Published online by Cambridge University Press:  12 April 2021

Abeer A. Al-Rabayah Open the ORCID record for Abeer A. Al-Rabayah [Opens in a new window]  and
Saad M. Jaddoua
Abeer A. Al-Rabayah*
Affiliation:
Department of Pharmacy, Center for Drug Policy and Technology Assessment, King Hussein Cancer Center, Queen Rania Street, PO Box 1269, Al-Jubeiha, Amman11941, Jordan
Saad M. Jaddoua
Affiliation:
Department of Pharmacy, King Hussein Cancer Center, Queen Rania Street, PO Box 1269, Al-Jubeiha, Amman11941, Jordan
*
Author for correspondence: Abeer A. Al-Rabayah, E-mail: ARabaiah@khcc.jo
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Abstract

Objective

To describe the establishment of, and assess the implementation of, a hospital-based health technology assessment (HTA) program in a comprehensive cancer center in Jordan.

Methods

This is a cross-sectional assessment study of the HTA program from 2008 to 2018. We used an indicator-based assessment that included structural, process, and outcome indicators. Structural indicators measured the program's enablers. Process indicators measured activities and outputs, whereas outcome indicators measured the program impact. A data collection form was prepared to collect data related to each indicator.

Results

The program met its core structural and process indicators. The Center for Drug Policy and Technology Assessment was established as an organizational entity to conduct assessments. A functional decision-making entity is available. There are competent pharmacists to conduct assessments, including economic evaluation and decision analytical modeling. There is a structured capacity building program that has been implemented within the last 5 years. Specific submission, assessment, and appraisal processes were established and implemented. Reference methodological guidelines for efficacy, safety, and cost-effectiveness assessments were developed and used by assessors. Thirty-one HTA reports were produced from 2012 to 2018 with a 100 percent utilization rate. Twenty-three medications were listed under restriction, and eight were rejected. The prices of twenty-one medications out of the twenty-three listed medications were reduced based on the HTA assessment results.

Conclusion

The HTA program at the King Hussein Cancer Center (KHCC) in Jordan is functional, is effective with a high utilization rate of produced assessments, and is having a positive impact on price reductions.

Keywords

Drug policyHospitalsFormulary listingEconomic evaluationOncology
Type
Policy
Information
International Journal of Technology Assessment in Health Care , Volume 37 , Issue 1 , 2021 , e55
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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References

Morgan, S, Lopert, R, Greyson, D. Toward a definition of pharmaceutical innovation. Open Med. 2008;2:e4–7.Google Scholar
Sampietro-Colom, L, Martin, J. Hospital-based health technology assessment: The next frontier. In: Sampietro-Colom, L, Martin, J, editors. Hospital-based health technology assessment: The next frontier for health technology assessment. Cham: Springer International Publishing; 2016. p. 3–11.CrossRefGoogle Scholar
Sampietro-Colom, L, Lach, K, Cicchetti, A, KIdholm, K, Pasternack, I, Fure, B, et al. 2015. The AdHopHTA handbook: A handbook of hospital-based health technology assessment (HB-HTA). Public deliverable: The AdHopHTA project (FP7/2007–2013 grant agreement nr 305018).Google Scholar
Menon, D, Stafinski, T. Health technology assessment in Canada: 20 years strong? Value Health. 2009;12:S14–19.CrossRefGoogle ScholarPubMed
Attieh, R, Gagnon, MP. Implementation of local/hospital-based health technology assessment initiatives in low- and middle-income countries. Int J Technol Assess Health Care. 2012;28:445–51. Epub 2012/09/21. doi:10.1017/S026646231200058X. PMID: 22995126.CrossRefGoogle ScholarPubMed
The World Factbook — Central Intelligence Agency [Internet]. 2017 [cited 2017 Nov 24]. Available from: https://www.cia.gov/library/publications/the-world-factbook/geos/jo.html.Google Scholar
New country classification by income level: 2018–2019. The World Bank. [cited 2019 May 10]. Available from: https://blogs.worldbank.org/opendata/new-country-classifications-income-level-2018-2019.Google Scholar
High Health Council. Jordan National Health Accounts 2013. Technical Report No. 6. Amman [Internet]. 2016 [cited 2019 May 10]. Available from: http://www.hhc.gov.jo/uploadedimages/NHA%202013.pdf.Google Scholar
High Health Council. The National Strategy for Health Sector in Jordan 2016–2020 [cited 2019 May 10]. Available from: http://www.hhc.gov.jo/uploadedimages/1fe9eeb0-590b-4b51-82e8-7013e98178de.pdf.Google Scholar
Joint Commission International. Joint Commission International Standard [Internet]. [cited 2020 Nov 25]. Available from: https://www.jointcommissioninternational.org/standards/.Google Scholar
Center for Diseases Control and Prevention. Program performance and evaluation office indicators [Internet]. [cited 2020 Aug 8]. Available from: https://www.cdc.gov/eval/indicators/index.htm.Google Scholar
Opadeyi, AO, Fourrier-Réglat, A, Isah, AO. Assessment of the state of pharmacovigilance in the South-South zone of Nigeria using WHO pharmacovigilance indicators. BMC Pharmacol Toxicol. 2018;19:27. EPub 2018/05/31. doi:10.1186/s40360-018-0217-2.CrossRefGoogle ScholarPubMed
Drummond, MF, Schwartz, JS, Jönsson, B, Luce, BR, Neumann, PJ, Siebert, U, et al. Key principles for the improved conduct of health technology assessments for resource allocation decisions. Int J Technol Assess Health Care. 2008;24:244–58; discussion 362–8. doi:10.1017/S0266462308080343. PMID: 18601792.CrossRefGoogle ScholarPubMed
Strengthening Pharmaceutical Systems (SPS) Program. Indicator-based pharmacovigilance assessment tool: Manual for conducting assessments in developing countries. Submitted to the U.S. Agency for International Development by the SPS Program. Arlington, VA: Management Sciences for Health; 2009.Google Scholar
McGregor, M, Brobhy, JM. End-user involvement in health technology assessment (HTA) development: A way to increase impact. Int J Technol Assess Health Care. 2005;21:263–7.CrossRefGoogle ScholarPubMed
Catananti, C, Cicchetti, A, Marchetti, M. Hospital based HTA: Evidences from policlinico “A. Gemelli” university hospital. Ital J Public Health. 2005;2:23–9.Google Scholar
Training Course on Pharmacoeconomics: Evidence, Money, and Selection of Medicines, Jordan, 2014. Available from: https://www.who.int/selection_medicines/pharmacoeconomics/en/.Google Scholar
Ron Goeree. Health technology assessment and economic evaluation workshop. Amman, Jordan: King Hussein Cancer Center; 2018.Google Scholar
Abeer Al Rabayah. Introduction to health technology assessment training course. Amman, Jordan: King Hussein Cancer Center; 2018.Google Scholar
Al Rabayah, AA, Al Froukh, RF, Sawalha, RDA. Capacity-building programme in health technology assessment for hospital pharmacists in a low- to middle-income country. J Pharm Health Serv Res Sep. 2018;9:275–80. doi:10.1111/jphs.12241.CrossRefGoogle Scholar
Drummond, M, O'Brien, B, Stoddart, G, O'Brien B, Stoddart G, et al. Methods for the economic evaluation of health care programmes. Oxford: Oxford University Press; 2015.Google Scholar
Philips, Z, Ginnelly, L, Sculpher, M, Claxton, K, Golder, S, Riemsma, R, et al. Review of guidelines for good practice in decision-analytic modelling in health technology assessment. Health Technol Assess. 2004;8:iii–iv, ix–xi, 1–158. doi:10.3310/hta8360. PMID: 15361314.CrossRefGoogle ScholarPubMed
Caro, JJ, Briggs, AH, Siebert, U, Kuntz, KM. Modeling good research practices–overview: A report of the ISPOR-SMDM Modeling Good Research Practices Task Force-1. Value Health. 2012;15:796–803.CrossRefGoogle ScholarPubMed
Eddy, DM, Hollingworth, W, Caro, JJ, Tsevat, J, McDonald, KM, Wong, JB. Model transparency and validation: A report of the ISPOR-SMDM Modeling Good Research Practices Task Force-7. Med Decis Making. 2012;32:733–43.CrossRefGoogle ScholarPubMed
Critical Appraisal Skills Programme. CASP Checklists [online] 2019. Available from: https://casp-uk.net/casp-tools-checklists/ [accessed 2020 Dec 22].Google Scholar
Higgins, JPT, Altman, DG, Gøtzsche, PC, Jüni, P, Moher, D, Oxman, AD, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.CrossRefGoogle ScholarPubMed
Jansen, JP, Fleurence, R, Devine, B, Itzler, R, Barrett, A, Hawkins, N, et al. Interpreting indirect treatment comparisons and network meta-analysis for health-care decision making: Report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices: Part 1. Value Health. 2011;14:417–28. doi:10.1016/j.jval.2011.04.002. PMID: 21669366.CrossRefGoogle ScholarPubMed
Santos, AS, Guerra-Junior, AA, Godman, B, Morton, A, Ruas, CM. Cost-effectiveness thresholds: Methods for setting and examples from around the world. Expert Rev Pharmacoeconomics Outcomes Res. 2018;18:277–88.CrossRefGoogle ScholarPubMed
Jabr, M, Treish, I. Establishment of a cost-effectiveness (CE) threshold at King Hussein Cancer Center-imatinib in chronic myelogenous leukemia (CML). Value Health. 2008;11,A657.CrossRefGoogle Scholar
Gagnon, MP, Desmartis, M, Poder, T, Witteman, W. Effects and repercussions of local/hospital-based health technology assessment (HTA): A systematic review. Syst Rev. 2014;3:129. EPub 2014/10/28. doi:10.1186/2046-4053-3-129.CrossRefGoogle ScholarPubMed
Oortwijn, WJ, Hanney, SR, Ligtvoet, A, Hoorens, S, Wooding, S, Grant, J, et al. Assessing the impact of health technology assessment in The Netherlands. Int J Technol Assess Health Care. 2008;24:259–69. doi:10.1017/S0266462308080355.CrossRefGoogle ScholarPubMed
Van der Wilt, G, Rovers, M, Oortwijn, W, Grutters, J. Hospital-based HTA at Radboud University Medical Center in the Netherlands: Welcome to reality. In: Colom, L, Martin, J, editors. Hospital-based health technology assessment: The next frontier for health technology assessment. 1st ed. Cham, Switzerland: Springer International Publishing; 2016. p. 45–55.CrossRefGoogle Scholar
Roine, R, Pasternack, I. HTA activities in Finnish hospitals. In: Colom, L, Martin, J, editors. Hospital-based health technology assessment: The next frontier for health technology assessment. 1st ed. Cham, Switzerland: Springer International Publishing; 2016. p. 29–36.CrossRefGoogle Scholar
Kidholm, K, Ølholm, AM. Hospital-based HTA in Denmark. In: Colom, L, Martin, J, editors. Hospital-based health technology assessment: The next frontier for health technology assessment. 1st ed. Cham, Switzerland: Springer International Publishing; 2016. p. 39–44.CrossRefGoogle Scholar
Kahveci, R, Tütüncü, T, Yüksek, YN, Küçük, EO, Koç, EM, Zengin, N. Hospital-based HTA in Turkey. In: Colom, L, Martin, J, editors. Hospital-based health technology assessment: The next frontier for health technology assessment. 1st ed. Cham, Switzerland: Springer International Publishing; 2016. p. 95–105.CrossRefGoogle Scholar
Jivegård, L, Bergh, C, Kindblom, J, et al. Activity-based HTA: Hospital-based HTA performed by clinicians with support and quality control, the Sahlgrenska University Hospital HTA-Centrum experience (Sweden). In: Colom, L, Martin, J, editors. Hospital-based health technology assessment: The next frontier for health technology assessment. 1st ed. Cham, Switzerland: Springer International Publishing; 2016. p. 15–28.CrossRefGoogle Scholar
Yazdizadeh, B, Mohtasham, F, Velayati, A. Impact assessment of Iran's health technology assessment programme. Health Res Policy Syst. 2018;16:15. doi:10.1186/s12961-018-0286-0.CrossRefGoogle ScholarPubMed
Marchetti, M, Cicchetti, A. The HTA and innovation unit at the A. Gemelli university hospital (Italy). In: Colom, L, Martin, J, editors. Hospital-based health technology assessment: The next frontier for health technology assessment. 1st ed. Switzerland: Springer International Publishing; 2016. p. 85–94.CrossRefGoogle Scholar
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