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Use of whole-genome sequencing to guide a Clostridioides difficile diagnostic stewardship program

Published online by Cambridge University Press:  15 May 2019

Kunal K. Jakharia ,
Ghassan Ilaiwy ,
Siobhan S. Moose ,
Masashi Waga ,
Lakshmi Appalla ,
Joel D. McAlduff ,
Lynne V. Karanfil ,
Patrick T. McGann  and
Glenn W. Wortmann Open the ORCID record for Glenn W. Wortmann [Opens in a new window]
Kunal K. Jakharia
Affiliation:
Department of Internal Medicine, MedStar Washington Hospital Center, Washington, DC
Ghassan Ilaiwy
Affiliation:
Department of Internal Medicine, MedStar Washington Hospital Center, Washington, DC
Siobhan S. Moose
Affiliation:
Departments of Infection Prevention and Infectious Diseases, MedStar Washington Hospital Center, Washington, DC
Masashi Waga
Affiliation:
Department of Pathology and Laboratory Medicine, MedStar Washington Hospital Center, Washington, DC
Lakshmi Appalla
Affiliation:
Multi-Drug Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, MD
Joel D. McAlduff
Affiliation:
Information Services, MedStar Health, Columbia, Maryland
Lynne V. Karanfil
Affiliation:
Infection Prevention, MedStar Institute for Quality and Safety, Columbia, Maryland
Patrick T. McGann
Affiliation:
Multi-Drug Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, MD
Glenn W. Wortmann*
Affiliation:
Departments of Infection Prevention and Infectious Diseases, MedStar Washington Hospital Center, Washington, DC Infection Prevention, MedStar Institute for Quality and Safety, Columbia, Maryland
*
Author for correspondence: Glenn W. Wortmann, Email: Glenn.W.Wortmann@medstar.net
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Abstract

Whole-genome sequencing (WGS) has yielded new insights into the transmission patterns of healthcare facility-onset Clostridioides difficile infection (HO-CDI). WGS results prompted a focused diagnostic stewardship program, which was associated with a significant and sustained decrease in HO-CDI at large, urban hospital.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 40 , Issue 7 , July 2019 , pp. 804 - 806
Creative Commons
This work is classified, for copyright purposes, as a work of the U.S. Government and is not subject to copyright protection within the United States.
Copyright
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved

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Footnotes

PREVIOUS PRESENTATION. Preliminary results of this work were presented at the 2018 Infectious Diseases Society of America meeting on October 4, 2018, in San Francisco, California.

References

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