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Unintended Consequences of Pretransplant Vancomycin-Resistant Enterococcus Screening on Antimicrobial Stewardship Among Allogeneic Hematopoietic Cell Transplant Recipients

Published online by Cambridge University Press:  28 March 2018

Erica J. Stohs ,
Trenton MacAllister ,
Steven A. Pergam ,
Elizabeth M. Krantz ,
Rupali Jain ,
Ania Sweet  and
Catherine Liu
Erica J. Stohs*
Affiliation:
Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
Trenton MacAllister
Affiliation:
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
Steven A. Pergam
Affiliation:
Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
Elizabeth M. Krantz
Affiliation:
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
Rupali Jain
Affiliation:
Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington Department of Pharmacy, University of Washington, Seattle, Washington.
Ania Sweet
Affiliation:
Department of Pharmacy, University of Washington, Seattle, Washington.
Catherine Liu
Affiliation:
Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
*
Address correspondence to Erica Stohs, MD MPH, 1100 Fairview Ave, North, E4-100, Seattle, WA 98109 (estohs@fredhutch.org).
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Abstract

We examined vancomycin-resistant enterococci (VRE)-directed antimicrobial use and VRE bacteremia in a cohort of allogeneic hematopoietic cell transplantation patients from a center where VRE screening is standard prior to transplant. In this cohort, VRE bacteremia (VREB) was infrequent. In patients without VREB, colonized patients received VRE therapy more often than noncolonized patients.

Infect Control Hosp Epidemiol 2018;39:730–733

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 39 , Issue 6 , June 2018 , pp. 730 - 733
Copyright
© 2018 by The Society for Healthcare Epidemiology of America. All rights reserved 

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Footnotes

PREVIOUS PRESENTATION. Portions of this work were presented at IDWeek on October 6, 2017, in San Diego, California.

References

REFERENCES

1. Alevizakos, M, Gaitanidis, A, Nasioudis, D, Tori, K, Flokas, ME, Mylonakis, E. Colonization with vancomycin-resistant enterococci and risk for bloodstream infection among patients with malignancy: a systematic review and meta-analysis. Open Forum Infect Dis 2017;4:1–10.Google Scholar
2. Tavadze, M, Rybicki, L, Mossad, S, et al. Risk factors for vancomycin-resistant enterococcus bacteremia and its influence on survival after allogeneic hematopoietic cell transplantation. Bone Marrow Transpl 2014;49:1310–1316.CrossRefGoogle ScholarPubMed
3. Dubberke, ER, Hollands, JM, Georgantopoulos, P, et al. Vancomycin-resistant enterococcal bloodstream infections on a hematopoietic stem cell transplant unit: Are the sick getting sicker? Bone Marrow Transpl 2006;38:813–819.Google Scholar
4. Lisboa, LF, Miranda, BG, Vieira, MB, et al. Empiric use of linezolid in febrile hematology and hematopoietic stem cell transplantation patients colonized with vancomycin-resistant Enterococcus spp. Int J Infect Dis 2015;33:171–176.Google Scholar
5. Freifeld, AG, Bow, EJ, Sepkowitz, KA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 Update by the Infectious Diseases Society of America. Clin Infect Dis 2011;52:e56–e93.Google Scholar
6. DiPippo, AJ, Tverdek, FP, Tarrand, JJ, et al. Daptomycin non-susceptible Enterococcus faecium in leukemia patients: role of prior daptomycin exposure. J Infect 2017;74:243–247.Google Scholar
7. Krull, M, Klare, I, Ross, B, et al. Emergence of linezolid- and vancomycin-resistant Enterococcus faecium in a department for hematologic stem cell transplantation. Antimicrob Resist Infect Control 2016;5:31.Google Scholar
8. Banach, DB, Bearman, G, Barnden, M, et al. Duration of contact precautions for acute-care settings. Infect Control Hosp Epidemiol 2018:1–18.Google Scholar
9. Au, BKC, Gooley, TA, Armand, P, et al. Reevaluation of the pretransplant assessment of mortality score after allogeneic hematopoietic transplantation. Biol Blood Marrow Transpl 2015;21:848–854.Google Scholar
10. Zasowski, EJ, Claeys, KC, Lagnf, AM, Davis, SL, Rybak, MJ. Time is of the essence: the impact of delayed antibiotic therapy on patient outcomes in hospital-onset enterococcal bloodstream infections. Clin Infect Dis 2016;62:1242–1250.Google Scholar
11. Webb, BJ, Healy, R, Majers, J, et al. Prediction of bloodstream infection due to vancomycin-resistant enterococcus in patients undergoing leukemia induction or hematopoietic stem-cell transplantation. Clin Infect Dis 2017;64:1753–1759.Google Scholar
12. Hefazi, M, Damlaj, M, Alkhateeb, H, et al. Vancomycin‐resistant enterococcus colonization and bloodstream infection: prevalence, risk factors, and the impact on early outcomes after allogeneic hematopoietic cell transplantation in patients with acute myeloid leukemia. Transpl Infect Dis 2016;18:913–920.Google Scholar
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