Hostname: page-component-848d4c4894-4rdrl Total loading time: 0 Render date: 2024-07-01T01:04:46.846Z Has data issue: false hasContentIssue false

Polymyxin flushes for endotracheal tube suction catheters in extremely low birth-weight infants: Any benefit in preventing ventilator-associated events?

Published online by Cambridge University Press:  15 November 2022

Michael J. Edzards*
Affiliation:
Department of Infectious Disease, Children’s Minnesota, Minneapolis, Minnesota
Marni B. Jacobs
Affiliation:
Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, San Diego, CA
Xiaoyan Song
Affiliation:
Department of Infection Control and Epidemiology, Children’s National Health Systems, Washington, DC
Sudeepta K. Basu
Affiliation:
Department of Neonatology, Children’s National Health System, Washington, DC
Rana F. Hamdy
Affiliation:
Department of Infectious Disease, Children’s National Health System, Washington, DC
*
Author for correspondence: Michael J. Edzards, E-mail: michael.edzards@childrensmn.org.

Abstract

We report that receipt of polymyxin B endotracheal tube suction catheter flushes did not reduce the incidence of pediatric ventilator-associated events (PedVAE) in infants weighing <1,000 g in this retrospective study. Incidence of PedVAE in our group of extremely low birth-weight infants was 6 per 1,000 ventilator days.

Type
Concise Communication
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

PREVIOUS PRESENTATION. Preliminary data were presented as a poster at IDWeek 2018 on October 3–7, 2018, in San Francisco, California (https://idsa.confex.com/idsa/2018/webprogram/Paper73270.html).

References

Venkatachalam, V, Hendley, JO, Willson, DF. The diagnostic dilemma of ventilator-associated pneumonia in critically ill children. Pediatr Crit Care Med 2011;12:286296.CrossRefGoogle ScholarPubMed
Cernada, M, Aguar, M, Brugada, M, et al. Ventilator-associated pneumonia in newborn infants diagnosed with an invasive bronchoalveolar lavage technique: a prospective observational study. Pediatr Crit Care Med 2013;14:5561.CrossRefGoogle ScholarPubMed
Marchand, S, Poisson, D, Borderon, JC, et al, 1990. Randomized study of vancomycin pharyngeal instillation as a prophylaxis of bronchopulmonary infection in intubated neonates. Biol Neonate 1990;58:241246.CrossRefGoogle ScholarPubMed
Liberati, A, D’Amico, R, Pifferi, S, Torri, V, Brazzi, L, Parmelli, E. Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. Cochrane Database Syst Rev 2009:CD000022.Google ScholarPubMed
Pediatric ventilator-associated event (PedVAE). Centers for Disease Control and Prevention website. https://www.cdc.gov/nhsn/pdfs/pscmanual/pedvae-current-508.pdf. Published 2019. Accessed April 20, 2019.Google Scholar
Harris, PA, Taylor, R, Thielke, R, Payne, J, Gonzalez, N, Conde, JG. Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 2009;42:377381.CrossRefGoogle ScholarPubMed
Cocoros, NM, Priebe, GP, Logan, LK, et al. A pediatric approach to ventilator-associated events surveillance. Infect Control Hosp Epidemiol 2017;38:327333.CrossRefGoogle ScholarPubMed
Falagas, ME, Siempos, II, Bliziotis, IA, Michalopoulos, A. Administration of antibiotics via the respiratory tract for the prevention of ICU-acquired pneumonia: a meta-analysis of comparative trials. Crit Care 2006;10:R123.CrossRefGoogle ScholarPubMed
Iosifidis, E, Pitsava, G, Roilides, E. Ventilator-associated pneumonia in neonates and children: a systematic analysis of diagnostic methods and prevention. Future Microbiol 2018;13:14311446.CrossRefGoogle ScholarPubMed
Supplementary material: File

Edzards et al. supplementary material

Edzards et al. supplementary material

Download Edzards et al. supplementary material(File)
File 28.3 KB