Hostname: page-component-7bb8b95d7b-wpx69 Total loading time: 0 Render date: 2024-09-19T12:35:55.020Z Has data issue: false hasContentIssue false
  • English
  • Français

Multicenter, Prospective Surveillance Study of Staphylococcus aureus Nasal Colonization in 28 Italian Intensive Care Units: The ISABEL Study

Published online by Cambridge University Press:  02 January 2015

Pierluigi Viale ,
Giovanni Gesu ,
Gaetano Privitera ,
Biagio Allaria ,
Nicola Petrosillo ,
Eleonora Zamparini ,
Luigia Scudeller  and
ISABEL Study Group
Pierluigi Viale*
Affiliation:
Clinica di Malattie Infettive, University of Bologna, Bologna, Italy
Giovanni Gesu
Affiliation:
Department of Microbiology, Ospedale Niguarda, Milan, Italy
Gaetano Privitera
Affiliation:
Experimental Disease Department, University of Pisa, Pisa, Italy
Biagio Allaria
Affiliation:
Resuscitation Service, Istituto dei Tumori, Milan, Italy
Nicola Petrosillo
Affiliation:
Second Infectious Diseases Division, National Institute for Infectious Diseases “L. Spallanzani,”Rome, Italy
Eleonora Zamparini
Affiliation:
Clinica di Malattie Infettive, University of Udine, Udine, Italy
Luigia Scudeller
Affiliation:
Clinical Epidemiology Unit, IRCCS Policlinico San Matteo, Pavia, Italy
*
Clinica di Malattie Infettive, University of Bologna, Policlinico S. Orsola-Malpighi, via Massarenti 11, 40138 Bologna, Italy (pierluigi.viale@unibo.it)
Get access Rights & Permissions [Opens in a new window]

Extract

The role of methicillin-resistant Staphylococcus aureus (MRSA) colonization as a predictor of invasive disease in intensive care unit (ICU) patients was established many years ago. The role of mefhicillin-susceptible Staphylococcus aureus (MSSA) colonization is more debated, although in a recent report patients who were carriers of MRSA or MSSA at ICU admission were found to be at increased risk. Whether carriage at ICU admission involves a higher risk of invasive infection than carriage acquired during an ICU stay has not been established. We report the results of a study aimed at estimating the frequency of S. aureus (MRSA and MSSA) colonization at admission and at discharge in patients admitted to several ICUs in Italy and at estimating the relationship between colonization status and infection by S. aureus.

Type
Research Briefs
Information
Infection Control & Hospital Epidemiology , Volume 32 , Issue 2 , February 2011 , pp. 193 - 197
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Roghmann, MC, Siddiqui, A, Plaisance, K, Standiford, H. MRSA colonization and the risk of MRSA bacteraemia in hospitalized patients with chronic ulcers. J Hosp Infect 2001;47(2):98–103.Google Scholar
2. Asensio, A, Guerrero, A, Quereda, C, Lizan, M, Martinez-Ferrer, M. Colonization and infection with methicillin-resistant Staphylococcus aureus: associated factors and eradication. Infect Control Hosp Epidemiol 1996;17(1):20–28.CrossRefGoogle ScholarPubMed
3. Coello, R, Glynn, JR, Gaspar, C, Picazo, JJ, Fereres, J. Risk factors for developing clinical infection with methicillin-resistant Staphylococcus aureus (MRSA) amongst hospital patients initially only colonized with MRSA. J Hosp Infect 1997;37(1):39–46.Google Scholar
4. Honda, H, Krauss, MJ, Coopersmith, CM, et al. Staphylococcus aureus nasal colonization and subsequent infection in intensive care unit patients: does methicillin resistance matter? Infect Control Hosp Epidemiol 2010;31(6):584–591.Google Scholar
5. Crowe, MJ, Cooke, EM. Review of case definitions for nosocomial infection–towards a consensus. Presentation by the Nosocomial Infection Surveillance Unit (NISU) to the Hospital Infection Liaison Group, subcommittee of the Federation of Infection Societies (FIS). J Hosp Infect 1998;39(1):3–11.CrossRefGoogle Scholar
6. von Eiff, C, Becker, K, Machka, K, Stammer, H, Peters, G. Nasal carriage as a source of Staphylococcus aureus bacteremia. N Engl J Med 2001;344(1):11–16.Google Scholar
7. Huang, SS, Platt, R. Risk of methicillin-resistant Staphylococcus aureus infection after previous infection or colonization. Clin Infect Dis 2003;36(3):281–285.Google Scholar
8. Clancy, M, Graepler, A, Wilson, M, Douglas, I, Johnson, J, Price, CS. Active screening in high-risk units is an effective and cost-avoidant method to reduce the rate of methicillin-resistant Staphylococcus aureus infection in the hospital. Infect Control Hosp Epidemiol 2006;27(10):1009–1017.Google Scholar
9. Troche, G, Joly, LM, Guibert, M, Zazzo, JF. Detection and treatment of antibiotic-resistant bacterial carriage in a surgical intensive care unit: a 6-year prospective survey. Infect Control Hosp Epidemiol 2005;26(2):161–165.CrossRefGoogle Scholar
10. Lim, MS, Marshall, CL, Spelman, D. Carriage of multiple subtypes of methicillin-resistant Staphylococcus aureus by intensive care unit patients. Infect Control Hosp Epidemiol 2006;27(10):1063–1067.Google Scholar