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Integron Class 1 Reservoir among Highly Resistant Gram-Negative Microorganisms Recovered at a Dutch Teaching Hospital

Published online by Cambridge University Press:  02 January 2015

Marlies J. Mooij ,
Ina Willemsen ,
Marihe Lobbrecht ,
Christina Vandenbroucke-Grauls ,
Jan Kluytmans  and
Paul H. M. Savelkoul
Marlies J. Mooij
Affiliation:
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, the Netherlands
Ina Willemsen
Affiliation:
Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda, the Netherlands
Marihe Lobbrecht
Affiliation:
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, the Netherlands
Christina Vandenbroucke-Grauls
Affiliation:
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, the Netherlands
Jan Kluytmans
Affiliation:
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, the Netherlands Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda, the Netherlands
Paul H. M. Savelkoul*
Affiliation:
Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, the Netherlands
*
Department of Medical Microbiology and Infection Control, VU University Medical Center, PO Box 7057, 1007MB Amsterdam, the Netherlands (p.savelkoul@vumc.nl)
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Abstract

Integrons play an important role in the dissemination of resistance genes among bacteria. Nearly 70% of highly resistant gram-negative bacteria isolated at a tertiary care hospital harbored an integron. Epidemiologic analysis suggests that horizontal gene transfer is an important mechanism of resistance spread and has a greater contribution than cross-transmission to levels of resistance in settings where highly resistant gram-negative bacteria are endemic.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 30 , Issue 10 , October 2009 , pp. 1015 - 1018
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2009

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