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Identification of four patients with colistin-resistant Escherichia coli containing the mobile colistin resistance mcr-1 gene from a single health system in Michigan

Published online by Cambridge University Press:  10 July 2019

Oryan Henig ,
Laura J. Rojas ,
Michael A. Bachman ,
Susan D. Rudin ,
Brenda M. Brennan ,
Marty K. Soehnlen ,
Kelly L. Jones ,
John P. Mills ,
Carey R. Dombecki  and
Amanda M. Valyko
...Show all authors
Oryan Henig
Affiliation:
Infectious Diseases Division, Rambam Health Care Campus, Haifa, Israel
Laura J. Rojas
Affiliation:
Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio Department of Medicine, Case Western Reserve University, Cleveland, Ohio
Michael A. Bachman
Affiliation:
Department of Pathology, University of Michigan, Medical School, Ann Arbor, Michigan
Susan D. Rudin
Affiliation:
Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio Department of Medicine, Case Western Reserve University, Cleveland, Ohio
Brenda M. Brennan
Affiliation:
Michigan Department of Health and Human Services (MDHHS)Bureau of Epidemiology and Population Health, Lansing, Michigan
Marty K. Soehnlen
Affiliation:
Michigan Department of Health and Human Service (MDHHS)Bureau of Laboratories, Lansing, Michigan
Kelly L. Jones
Affiliation:
Michigan Department of Health and Human Service (MDHHS)Bureau of Laboratories, Lansing, Michigan
John P. Mills
Affiliation:
Department of Medicine, Division of Infectious Diseases, University of Michigan, Medical School, Ann Arbor, Michigan
Carey R. Dombecki
Affiliation:
Department of Infection Prevention and Epidemiology, Michigan Medicine, Ann Arbor, Michigan
Amanda M. Valyko
Affiliation:
Department of Infection Prevention and Epidemiology, Michigan Medicine, Ann Arbor, Michigan
Steven H. Marshall
Affiliation:
Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio Department of Medicine, Case Western Reserve University, Cleveland, Ohio Department of Microbiology and Molecular Biology, Case Western Reserve University, Cleveland, Ohio
Robert A. Bonomo
Affiliation:
Department of Medicine, Case Western Reserve University, Cleveland, Ohio Department of Microbiology and Molecular Biology, Case Western Reserve University, Cleveland, Ohio Departments of Pharmacology, Molecular Biology and Microbiology, Biochemistry, and Proteonomic and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio
Keith S. Kaye
Affiliation:
Department of Medicine, Division of Infectious Diseases, University of Michigan, Medical School, Ann Arbor, Michigan
Laraine Washer*
Affiliation:
Infectious Diseases Division, Rambam Health Care Campus, Haifa, Israel Department of Infection Prevention and Epidemiology, Michigan Medicine, Ann Arbor, Michigan
*
Author for correspondence: Laraine Washer, Email: laraine@med.umich.edu
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Abstract

Clinical Enterobacteriacae isolates with a colistin minimum inhibitory concentration (MIC) ≥4 mg/L from a United States hospital were screened for the mcr-1 gene using real-time polymerase chain reaction (RT-PCR) and confirmed by whole-genome sequencing. Four colistin-resistant Escherichia coli isolates contained mcr-1. Two isolates belonged to the same sequence type (ST-632). All subjects had prior international travel and antimicrobial exposure.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 40 , Issue 9 , September 2019 , pp. 1059 - 1062
Copyright
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved. 

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References

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