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Efficacy of Combination of N-acetylcysteine, Gentamicin, and Amphotericin B for Prevention of Microbial Colonization of Ventricular Assist Devices

Published online by Cambridge University Press:  02 January 2015

Maria D. Hernandez ,
Mohammad D. Mansouri ,
Saima Aslam ,
Barry Zeluff  and
Rabih O. Darouiche
Maria D. Hernandez
Affiliation:
Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas
Mohammad D. Mansouri
Affiliation:
Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas Center for Prostheses Infection, Baylor College of Medicine, Houston, Texas
Saima Aslam
Affiliation:
Michael E. DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas St. Luke's Episcopal Hospital, Baylor College of Medicine, Houston, Texas Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas
Barry Zeluff
Affiliation:
St. Luke's Episcopal Hospital, Baylor College of Medicine, Houston, Texas
Rabih O. Darouiche*
Affiliation:
Michael E. DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas Center for Prostheses Infection, Baylor College of Medicine, Houston, Texas
*
Center for Prostheses Infection, 1333 Moursund Avenue, Suite A221, Houston, TX 77030 (rdarouiche@aol.com)
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Abstract

We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 30 , Issue 2 , February 2009 , pp. 190 - 192
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2009

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