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DNA Analysis in the Study of the Epidemiology of Nosocomial Candidiasis

Published online by Cambridge University Press:  02 January 2015

Louise M. Dembry ,
Jose A. Vazquez  and
Marcus J. Zervos
Louise M. Dembry
Affiliation:
Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut
Jose A. Vazquez
Affiliation:
Wayne State University School of Medicine, Detroit, Michigan
Marcus J. Zervos*
Affiliation:
Wayne State University School of Medicine, Detroit, Michigan William Beaumont Hospital, Royal Oak, Michigan
*
Clinical Associate Professor of Medicine, Wayne State University School of Medicine, William Beaumont Hospital, 3601 West Thirteen Mile Rd., Royal Oak, MI 48073
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Extract

Pathogenic Candida species are ubiquitous organisms usually confined to human and animal reservoirs, but they can be recovered from soil, food, and the hospital environment. They are normal inhabitants of the female genital tract and the gastrointestinal tract, including the oropharynx, rectum, and perineum. Candida species are increasingly important nosocomial pathogens in immunocompromised patients, as well as in intensive care and postoperative patients. The changing patterns and the increasing incidence of disseminated Candida infection has been demonstrated in large autopsy series1 and is related to the modem aggressive treatment of malignancy and intensive supportive care of hospitalized patients. Current therapeutic regimens have resulted in greater numbers of cancer patients achieving and maintaining remission despite more prolonged periods of neu-tropenia. Greater success in the treatment of bacterial and viral infections has resulted in longer patient survival and hence an increased susceptibility of developing severe Candida infections. Candida species are now the fourth most commonly recovered organism from blood cultures of hospitalized patients with a crude mortality for Candida albicans fungemia of approximately 80% to 85%.

Type
Molecular Hospital Epidemiology
Information
Infection Control & Hospital Epidemiology , Volume 15 , Issue 1 , January 1994 , pp. 48 - 54
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1994

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