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Antimicrobial resistance patterns of urine culture specimens from 27 nursing homes: Impact of a two-year antimicrobial stewardship intervention

Published online by Cambridge University Press:  06 May 2019

Meera Tandan Open the ORCID record for Meera Tandan [Opens in a new window] ,
Philip D. Sloane ,
Kimberly Ward ,
David J. Weber ,
Akke Vellinga ,
Christine E. Kistler  and
Sheryl Zimmerman
Meera Tandan*
Affiliation:
Discipline of General Practice, School of Medicine, National University of Ireland (NUI) Galway, Ireland
Philip D. Sloane
Affiliation:
Department of Family Medicine, University of North Carolina, Chapel Hill, North Carolina, United States Cecil G. Sheps Center for Health Service Research, University of North Carolina, Chapel Hill, North Carolina, United States
Kimberly Ward
Affiliation:
Cecil G. Sheps Center for Health Service Research, University of North Carolina, Chapel Hill, North Carolina, United States
David J. Weber
Affiliation:
Division of Infectious Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States Department of Epidemiology, Gillings School of GlobalPublic Health, University of North Carolina, Chapel Hill, North Carolina, United States
Akke Vellinga
Affiliation:
Discipline of General Practice, School of Medicine, National University of Ireland (NUI) Galway, Ireland Discipline of Bacteriology, School of Medicine, National University of Ireland (NUI) Galway, Ireland
Christine E. Kistler
Affiliation:
Department of Family Medicine, University of North Carolina, Chapel Hill, North Carolina, United States Cecil G. Sheps Center for Health Service Research, University of North Carolina, Chapel Hill, North Carolina, United States
Sheryl Zimmerman
Affiliation:
Cecil G. Sheps Center for Health Service Research, University of North Carolina, Chapel Hill, North Carolina, United States School of Social Work, University of North Carolina, Chapel Hill, North Carolina, United States
*
Author for correspondence: Meera Tandan, Email: tandan.meera@gmail.com, m.tandan1@nuigalway.ie
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Abstract

Objective:

Identify changes in the prevalence and antimicrobial resistance patterns of potentially pathogenic bacteria in urine cultures during a 2-year antimicrobial stewardship intervention program in nursing homes (NHs).

Design:

Before-and-after intervention study.

Setting:

The study included 27 NHs in North Carolina.

Methods:

We audited all urine cultures ordered before and during an antimicrobial stewardship intervention. Analyses compared culture rates, culture positive rates, and pathogen antimicrobial resistance patterns.

Results:

Of 6,718 total urine cultures collected, 68% were positive for potentially pathogenic bacteria. During the intervention, significant reductions in the urine culture and positive culture rates were observed (P = .014). Most of the identified potentially uropathogenic isolates were Escherichia coli (38%), Proteus spp (13%), and Klebsiella pneumoniae (12%). A significant decrease was observed during the intervention period in nitrofurantoin resistance among E. coli (P ≤ .001) and ciprofloxacin resistance among Proteus spp (P ≤ .001); however carbapenem resistance increased for Proteus spp (P ≤ .001). Multidrug resistance also increased for Proteus spp compared to the baseline. The high baseline resistance of E. coli to the commonly prescribed antimicrobials ciprofloxacin and trimethoprim-sulfamethoxazole (TMP/SMX) did not change during the intervention.

Conclusions:

The antimicrobial stewardship intervention program significantly reduced urine culture and culture-positive rates. Overall, very high proportions of antimicrobial resistance were observed among common pathogens; however, antimicrobial resistance trended downward but reductions were too small and scattered to conclude that the intervention significantly changed antimicrobial resistance. Longer intervention periods may be needed to effect change in resistance patterns.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 40 , Issue 7 , July 2019 , pp. 780 - 786
Copyright
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved 

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