Skip to main content Accessibility help
×
Home
Hostname: page-component-55597f9d44-dfw9g Total loading time: 0.247 Render date: 2022-08-17T15:02:24.314Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "useNewApi": true } hasContentIssue false

Randomized Controlled Trial to Determine the Impact of Probiotic Administration on Colonization With Multidrug-Resistant Organisms in Critically Ill Patients

Published online by Cambridge University Press:  27 August 2015

Jennie H. Kwon*
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Kerry M. Bommarito
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Kimberly A. Reske
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Sondra M. Seiler
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Tiffany Hink
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Hilary M. Babcock
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Marin H. Kollef
Affiliation:
Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri
Victoria J. Fraser
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Carey-Ann D. Burnham
Affiliation:
Departments of Pathology & Immunology and Pediatrics, Washington University School of Medicine, St. Louis, Missouri
Erik R. Dubberke
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
*
Address correspondence to Jennie H. Kwon, DO, Washington University School of Medicine, Division of Infectious Diseases, 6600 S Euclid Ave, Campus Box 8051, St. Louis, MO 63110 (JKwon@dom.wustl.edu).

Abstract

This was a randomized controlled pilot study of Lactobacillus rhamnosus GG versus standard of care to prevent gastrointestinal multidrug-resistant organism colonization in intensive care unit patients. Among 70 subjects, there were no significant differences in acquisition or loss of any multidrug-resistant organisms (P>.05) and no probiotic-associated adverse events.

Infect. Control Hosp. Epidemiol. 2015;36(12):1451–1454

Type
Concise Communications
Copyright
© 2015 by The Society for Healthcare Epidemiology of America. All rights reserved 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Lambert, ML, Suetens, C, Savey, A, et al. Clinical outcomes of health-care-associated infections and antimicrobial resistance in patients admitted to European intensive-care units: a cohort study. Lancet Infect Dis 2011;11:3038.CrossRefGoogle ScholarPubMed
2. Brusselaers, N, Vogelaers, D, Blot, S. The rising problem of antimicrobial resistance in the intensive care unit. Ann Intensive Care 2011;23:47.CrossRefGoogle Scholar
3. Donskey, CJ. The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens. Clin Infect Dis 2004;39:219226.CrossRefGoogle ScholarPubMed
4. Hink, T, Burnham, CA, Dubberke, ER. A systematic evaluation of methods to optimize culture-based recovery of Clostridium difficile from stool specimens. Anaerobe 2013;19:3943.CrossRefGoogle ScholarPubMed
5. de Regt, MJ, Willems, RJ, Hene, RJ, et al. Effects of probiotics on acquisition and spread of multiresistant enterococci. Antimicrob Agents Chemother 2010;54:28012805.CrossRefGoogle ScholarPubMed
6. Allen, SJ, Wareham, K, Wang, D, et al. Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial. Lancet 2013;382:12491257.CrossRefGoogle ScholarPubMed
7. Goldenberg, JZ, Ma, SS, Saxton, JD, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst 2013;5:CD006095.Google Scholar
8. Plummer, S, Weaver, MA, Harris, JC, et al. Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea. Int Microbiol 2004;7:5962.Google ScholarPubMed
9. Barraud, E, Bollaert, PE, Gibot, S. Impact of the administration of probiotics on mortality in critically ill adult patients: a meta-analysis of randomized controlled trials. Chest 2013;143:646655.CrossRefGoogle ScholarPubMed
10. Petrof, EO, Dhaliwal, R, Manzanares, W, et al. Probiotics in the critically ill: a systematic review of the randomized trial evidence. Crit Care Med 2012;40:32903302.CrossRefGoogle ScholarPubMed
15
Cited by

Save article to Kindle

To save this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Randomized Controlled Trial to Determine the Impact of Probiotic Administration on Colonization With Multidrug-Resistant Organisms in Critically Ill Patients
Available formats
×

Save article to Dropbox

To save this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about saving content to Dropbox.

Randomized Controlled Trial to Determine the Impact of Probiotic Administration on Colonization With Multidrug-Resistant Organisms in Critically Ill Patients
Available formats
×

Save article to Google Drive

To save this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about saving content to Google Drive.

Randomized Controlled Trial to Determine the Impact of Probiotic Administration on Colonization With Multidrug-Resistant Organisms in Critically Ill Patients
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *