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A multi-institutional outbreak of New Delhi metallo-β-lactamase–producing Escherichia coli with subsequent acquisition of the Klebsiella pneumoniae carbapenemase gene

Published online by Cambridge University Press:  29 December 2020

Ester Solter
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
Jason C. Kwong
Affiliation:
Microbilogical Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology at the Peter Doherty Institute for Infection & Immunity, University of Melbourne, Victoria, Australia Department of Infectious Disease, Austin Health, Heidelberg, Victoria, Australia
Aaron Walton
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel Barwon Health, Geelong, Victoria, Australia
Norelle Sherry
Affiliation:
Microbilogical Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology at the Peter Doherty Institute for Infection & Immunity, University of Melbourne, Victoria, Australia Department of Infectious Disease, Austin Health, Heidelberg, Victoria, Australia
Benjamin P. Howden
Affiliation:
Microbilogical Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology at the Peter Doherty Institute for Infection & Immunity, University of Melbourne, Victoria, Australia Department of Infectious Disease, Austin Health, Heidelberg, Victoria, Australia
M. Lindsay Grayson
Affiliation:
Department of Infectious Disease, Austin Health, Heidelberg, Victoria, Australia Department of Medicine, University of Melbourne, Victoria, Australia
David Schwartz
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
Elizabeth Temkin
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
Sammy Frenk
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
Yehuda Carmeli
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Mitchell J. Schwaber*
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
*
Author for correspondence: Mitchell J. Schwaber, E-mail: mitchells@tlvmc.gov.il

Abstract

We characterized 57 isolates from a 2-phase clonal outbreak of New Delhi metallo-β-lactamase–producing Eschericha coli, involving 9 Israeli hospitals; all but 1 isolate belonged to sequence-type (ST) 410. Most isolates in the second phase harbored blaKPC-2 in addition to blaNDM-5. Genetic sequencing revealed most dual-carbapenemase–producing isolates to be monophyletically derived from a common ancestor.

Type
Concise Communication
Copyright
© The Author(s), 2020. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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References

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A multi-institutional outbreak of New Delhi metallo-β-lactamase–producing Escherichia coli with subsequent acquisition of the Klebsiella pneumoniae carbapenemase gene
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A multi-institutional outbreak of New Delhi metallo-β-lactamase–producing Escherichia coli with subsequent acquisition of the Klebsiella pneumoniae carbapenemase gene
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