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Low infectivity among asymptomatic patients with a positive severe acute respiratory coronavirus virus 2 (SARS-CoV-2) admission test at a tertiary care center, 2020–2022

Published online by Cambridge University Press:  25 September 2023

Ralph Tayyar
Affiliation:
Stanford University School of Medicine, Stanford, California
Melanie A. Kiener*
Affiliation:
Stanford University School of Medicine, Stanford, California
Jane W. Liang
Affiliation:
Stanford University School of Medicine, Stanford, California
Gustavo Contreras
Affiliation:
Stanford University School of Medicine, Stanford, California
Guillermo Rodriguez-Nava
Affiliation:
Stanford University School of Medicine, Stanford, California
Alex N. Zimmet
Affiliation:
Stanford University School of Medicine, Stanford, California
Caitlin A. Contag
Affiliation:
Stanford University School of Medicine, Stanford, California
Krithika Srinivasan
Affiliation:
Stanford University School of Medicine, Stanford, California
Karen McIntyre
Affiliation:
Stanford University School of Medicine, Stanford, California
Aruna Subramanian
Affiliation:
Stanford University School of Medicine, Stanford, California
John Shepard
Affiliation:
Stanford University School of Medicine, Stanford, California
Lucy S. Tompkins
Affiliation:
Stanford University School of Medicine, Stanford, California
Benjamin A. Pinsky
Affiliation:
Stanford University School of Medicine, Stanford, California
Jorge L. Salinas
Affiliation:
Stanford University School of Medicine, Stanford, California
*
Author for correspondence: Melanie A. Kiener, MD, Infectious Diseases–Stanford Medicine, 300 Pasteur Dr, L-134, Stanford, CA 94035. Email: Mkiener8@stanford.edu

Abstract

We used a strand-specific RT-qPCR to evaluate viral replication as a surrogate for infectiousness among 242 asymptomatic inpatients with a positive severe acute respiratory coronavirus virus 2 (SARS-CoV-2) admission test. Only 21 patients (9%) had detectable SARS-CoV-2 minus-strand RNA. Because most patients were found to be noninfectious, our findings support the suspension of asymptomatic admission testing.

Type
Concise Communication
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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Footnotes

a

Authors of equal contribution.

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