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Impact of antibiotic heterogeneity by periodic antibiotic monitoring and supervision strategy at two units with different prevalences of multidrug-resistant organisms

Published online by Cambridge University Press:  09 June 2021

Surachai Chaononghin
Division of Infectious Diseases, Faculty of Medicine, Thammasat University, Prathum Thani, Thailand
Kittiya Jantarathaneewat
Department of Pharmaceutical Care, Faculty of Pharmacy, Thammasat University, Prathum Thani, Thailand
David J. Weber
University of North Carolina, Gillings School of Global Public Health, Chapel Hill, North Carolina, United States
David K. Warren
Division of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri, United States
Anucha Apisarnthanarak*
Division of Infectious Diseases, Faculty of Medicine, Thammasat University, Prathum Thani, Thailand
Author for correspondence: Anucha Apisarnthanarak, E-mail:


In an intensive care unit, antibiotic heterogeneity led to an increase in antibiotic heterogeneity index (P = .002) and a reduction in carbapenem-resistance Enterobacteriaceae incidence (P = .04). In a general medicine unit with low prevalence of multidrug-resistant organisms, antibiotic heterogeneity index and incidence of multidrug-resistant organisms did not improve.

Concise Communication
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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