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Epidemiology of Vancomycin-Resistant Enterococci with Reduced Susceptibility to Daptomycin

Published online by Cambridge University Press:  02 January 2015

Theresa Judge
Affiliation:
Department of Pharmacy Services, Detroit Medical Center, Detroit, Michigan
Jason M. Pogue
Affiliation:
Department of Pharmacy Services, Detroit Medical Center, Detroit, Michigan
Dror Marchaim
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
Kevin Ho
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
Srinivasa Kamatam
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
Shakila Parveen
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
Namita Tiwari
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
Priyanka Nanjireddy
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
Suchitha Bheemreddy
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
Caitlin Biedron
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
Sagar Mallikethi Lepakshi Reddy
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
Vijaykumar Khammam
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
Indu K. Chalana
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
Rajachendra Shekher Tumma
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
Vicki Collins
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
Adnan Yousuf
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
Paul R. Lephart
Affiliation:
Detroit Medical Center University Laboratories, Detroit, Michigan
Emily T. Martin
Affiliation:
Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan
Michael J. Rybak
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan
Keith S. Kaye
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
Kayoko Hayakawa*
Affiliation:
Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan
*
Harper University Hospital, 3990 John R Street, Detroit, MI 48084 (kayokohayakawa@gmail.com)

Abstract

A retrospective case–case control study was conducted, including 60 cases with daptomycin-nonsusceptible vancomycin-resistant enterococci (DNS-VRE) matched to cases with daptomycin-susceptible VRE and to uninfected controls (1:1:3 ratio). Immunosuppression, presence of comorbid conditions, and prior exposure to antimicrobials were independent predictors of DNS-VRE, although prior daptomycin exposure occurred rarely. In summary, a case–case control study identified independent risk factors for the isolation of DNS-VRE: immunosuppression, multiple comorbid conditions, and prior exposures to cephalosporines and metronidazole.

Type
Concise Communication
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2012

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