Skip to main content Accessibility help
×
Home
Hostname: page-component-568f69f84b-l2zqg Total loading time: 0.193 Render date: 2021-09-21T18:28:19.399Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

Clinical impact of matrix-assisted laser desorption ionization time-of-flight mass spectrometry for the management of inpatient pneumonia without additional antimicrobial stewardship support

Published online by Cambridge University Press:  12 July 2019

Ann Marie Porreca Kratz*
Affiliation:
Department of Pharmacy, St Luke’s University Hospital, Bethlehem, Pennsylvania
Kaede V. Sullivan
Affiliation:
Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania
Jason C. Gallagher
Affiliation:
Temple University School of Pharmacy, Philadelphia, Pennsylvania
*Corresponding
Author for correspondence: Ann Marie Porreca Kratz, 801 Ostrum Street, Bethlehem, PA 18015, E-mail: ann.porreca@sluhn.org

Abstract

We assessed whether implementation of matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry without antimicrobial stewardship support would impact antimicrobial utilization and clinical outcomes in inpatient pneumonia. Implementation significantly reduced time to organism identification and time to optimal therapy but did not have a detectable impact on clinical outcomes.

Type
Concise Communication
Copyright
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved. 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Dellit, T, Owens, R, McGowan, J, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program for enhancing antimicrobial stewardship. Clin Infect Dis 2007;44:159177.Google Scholar
Huang, AM, Newtown, D, Kunapuli, A, et al. Impact of rapid organism identification via matrix-assisted laser desorption/ionization time-of-flight combined with antimicrobial stewardship team intervention in adult patients with bacteremia and candidemia. Clin Infect Dis 2013;57:12371245.CrossRefGoogle ScholarPubMed
Nagel, JL, Huang, AM, Kunapuli, A, et al. Impact of antimicrobial stewardship intervention on coagulase-negative Staphylococcus blood cultures in conjunction with rapid diagnostic testing. J Clin Microbiol 2014;52:28492854.Google ScholarPubMed
Clerc, O, Pro’hom, G, Vogne, C, Bizzini, A, Calandra, T, Greub, G. Impact of matrix-assisted laser desorption ionization time-of-flight mass spectrometry on the clinical management of patients with gram-negative bacteremia: a prospective observational study. Clin Infect Dis 2013;56:11011107.Google ScholarPubMed
Vlek, AL, Bonten, MJ, Boel, CH. Direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry improves appropriateness of antibiotic treatment of bacteremia. PLoS One 2012;7(3):e32589.CrossRefGoogle ScholarPubMed
Holtzman, C, Whitney, D, Barlam, T, Miller, NS. Assessment of impact of peptide nucleic acid flurorescence in situ hybridization for rapid identification of coagulase-negative Staphylococcus in absence of antimicrobial stewardship intervention. J Clin Microbiol 2011;49:15811582.CrossRefGoogle Scholar
Beganovic, M, Costello, M, Wieczorkiewicz, SM. MALDI-TOF alone versus MALDI-TOF combined with real-time antimicrobial stewardship interventions on time to optimal antimicrobial therapy in patients with positive blood cultures. J Clin Microbiol 2017; 55. doi: 10.1128/JCM.02245-16.CrossRefGoogle ScholarPubMed
Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing, 28th ed. CLSI M100 Supplement. Wayne, PA: CLSI.Google Scholar
Wenzler, E, Goff, DA, Mangino, JE, Reed, EE, Wehr, A, Bauer, KA. Impact of rapid identification of Acinetobacter baumannii via matrix-assisted laser desorption ionization time-of-flight mass spectrometry combined with antimicrobial stewardship in patients with pneumonia and/or bacteremia. Diagn Microbiol Infect Dis 2016;84:6368.CrossRefGoogle ScholarPubMed
Mok, JH, Eom, JS, Jo, EJ, et al. Clinical utility of rapid pathogen identification using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in ventilated patients with pneumonia: a pilot study. Respirology 2016;21:321328.CrossRefGoogle ScholarPubMed

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Clinical impact of matrix-assisted laser desorption ionization time-of-flight mass spectrometry for the management of inpatient pneumonia without additional antimicrobial stewardship support
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Clinical impact of matrix-assisted laser desorption ionization time-of-flight mass spectrometry for the management of inpatient pneumonia without additional antimicrobial stewardship support
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Clinical impact of matrix-assisted laser desorption ionization time-of-flight mass spectrometry for the management of inpatient pneumonia without additional antimicrobial stewardship support
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *