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An outbreak of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infections among hospital personnel with high mRNA vaccine uptake

Part of: SARS-CoV-2/COVID-19

Published online by Cambridge University Press:  20 September 2021

Yael Tene ,
Katia Levytskyi ,
Amos Adler ,
Ora Halutz ,
Yael Paran ,
Hanoch Goldshmidt ,
Ayelet Itzhaki-Alfia ,
Tamar Halperin ,
Sarit Stepansky  and
Ronen Ben-Ami
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Yael Tene
Affiliation:
Division of Infectious Diseases, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel
Katia Levytskyi
Affiliation:
Clinical Microbiology Laboratory, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel
Amos Adler
Affiliation:
Clinical Microbiology Laboratory, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Ora Halutz
Affiliation:
Clinical Microbiology Laboratory, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel
Yael Paran
Affiliation:
Division of Infectious Diseases, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Hanoch Goldshmidt
Affiliation:
Division of Laboratories, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel
Ayelet Itzhaki-Alfia
Affiliation:
Department of Pathology, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel
Tamar Halperin
Affiliation:
Laboratory for HIV Diagnosis, The Crusaid Kobler AIDS Center, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel
Sarit Stepansky
Affiliation:
Epidemiology and Infection Prevention Unit, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel
Ronen Ben-Ami
Affiliation:
Division of Infectious Diseases, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Oryan Henig*
Affiliation:
Division of Infectious Diseases, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel Epidemiology and Infection Prevention Unit, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel
*
Author for correspondence: Oryan Henig, E-mail: Oryan.henig@gmail.com
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Abstract

Real-world studies have demonstrated impressive effectiveness of the BNT162b2 COVID-19 vaccine in preventing symptomatic and asymptomatic SARS-CoV-2 infection. We describe an outbreak of SARS-CoV-2 infections in a hospital with high vaccine uptake. We found a low secondary attack rate (7%), suggesting low infectivity of vaccinated persons with vaccine breakthrough SARS-CoV-2 infections.

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 44 , Issue 1 , January 2023 , pp. 114 - 117
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Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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References

Polack, FP, Thomas, SJ, Kitchin, N, et al. Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine. N Engl J Med 2020;383:2603–2615.CrossRefGoogle ScholarPubMed
Dagan, N, Barda, N, Kepten, E, et al. BNT162b2 mRNA COVID-19 vaccine in a nationwide mass vaccination setting. N Engl J Med 2021;384:1412–1423.CrossRefGoogle Scholar
Yanes-Lane, M, Winters, N, Fregonese, F, et al. Proportion of asymptomatic infection among COVID-19 positive persons and their transmission potential: a systematic review and meta-analysis. PLoS One 2020;15(11):e0241536.CrossRefGoogle ScholarPubMed
Levine-Tiefenbrun, M, Yelin, I, Katz, R, et al. Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine. Nat Med 2021;27:790–792.CrossRefGoogle ScholarPubMed
Shah, A GC, Bishop, J, Hanlon, P, et al. Effect of vaccination on transmission of COVID-19: an observational study in healthcare workers and their households. N Engl J Med 2021. doi: 10.1056/NEJMc2106757.Google Scholar
Angel, Y, Spitzer, A, Henig, O, et al. Association between vaccination with BNT162b2 and incidence of symptomatic and asymptomatic SARS-CoV-2 infections among healthcare workers. JAMA 2021;325:2457–2465.CrossRefGoogle Scholar
COVID-19 contact tracing communications toolkit for health departments. Centers for Disease Control and Prevention website. https://wwwcdc.gov/coronavirus/2019-ncov/php/contact-tracing-commshtml. Accessed June 4, 2021.Google Scholar
Madewell, ZJ, Yang, Y, Longini, IM Jr, Halloran, ME, Dean, NE. Household transmission of SARS-CoV-2: a systematic review and meta-analysis. JAMA Netw Open 2020;3(12):e2031756.CrossRefGoogle ScholarPubMed
Walsh, KA, Jordan, K, Clyne, B, et al. SARS-CoV-2 detection, viral load and infectivity over the course of an infection. J Infect 2020;81:357–371.CrossRefGoogle ScholarPubMed
Munitz, A, Yechezkel, M, Dickstein, Y, Yamin, D, Gerlic, M. BNT162b2 vaccination effectively prevents the rapid rise of SARS-CoV-2 variant B.1.1.7 in high-risk populations in Israel. Cell Rep Med 2021;2(5):100264.CrossRefGoogle ScholarPubMed