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A variation in mouse kidney pyruvate kinase activity determined by a mutant gene on chromosome 9

Published online by Cambridge University Press:  14 April 2009

F. M. Johnson ,
Fred Chasalow ,
Gretchen Anderson ,
Paul Macdougal ,
R. Wayne Hendren  and
Susan E. Lewis
F. M. Johnson
Affiliation:
Laboratory of Biochemical Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
Fred Chasalow
Affiliation:
Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, North Carolina 27709
Gretchen Anderson
Affiliation:
Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, North Carolina 27709
Paul Macdougal
Affiliation:
Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, North Carolina 27709
R. Wayne Hendren
Affiliation:
Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, North Carolina 27709
Susan E. Lewis
Affiliation:
Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, North Carolina 27709

Summary

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Pyruvate kinase activity was studied in kidney extracts of mice from various sources. One C57BL/6J female among several hundred examined expressed activity approximately one half of the normal level. This animal transmitted the trait, and a single gene responsible for the activity difference was identified and mapped to chromosome 9. Linkage with Mod-1 and dilute was established. A spontaneous mutation in the C57BL/6J strain apparently was responsible for the variant pyruvate kinase.

Type
Research Article
Information
Genetics Research , Volume 37 , Issue 2 , April 1981 , pp. 123 - 131
Copyright
Copyright © Cambridge University Press 1981

References

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